Navigation Links
Ceregene Reports Data From Parkinson's Disease Phase 2b Study
Date:4/19/2013

SAN DIEGO, April 19, 2013 /PRNewswire/ -- Ceregene, Inc. today announced the top-line data from its double-blind, randomized, controlled Phase 2b clinical study of CERE-120 (AAV-neurturin), a gene therapy product designed to deliver the neurotrophic factor neurturin, for Parkinson's disease.   The trial did not demonstrate statistically significant efficacy on the primary endpoint (UPDRS-motor off). However, one of the "key secondary endpoints" (Diary-off score), as defined and prespecified in the Statistical Analysis Plan, did produce statistically significant benefit. The trial also provided further evidence for the safety of CERE-120 and the dosing methods employed. A marked placebo effect was observed in this trial in that both the sham-surgery-control patients and the CERE-120 treated patients showed significant improvement following their surgery.

Fifty-one (51) patients with moderately advanced Parkinson's disease who could not be satisfactorily controlled with conventional Parkinson's medication were enrolled in the study at 11 leading clinical sites throughout the U.S.  Approximately half of the patients received CERE-120 while the other half received sham (placebo) surgery as a control.  Patients were monitored for 15-24 months to assess safety and changes in Parkinson's disease symptoms, using multiple endpoints such as the Unified Parkinson's Disease Rating Scale (UPDRS), Daily Diaries that assess motor function throughout the day, and PDQ-39 (a measure of quality of life), among others. Ceregene continues to analyze the data from this trial to gain as much information as possible.

Jeffrey M. Ostrove , Ph.D., president and chief executive officer of Ceregene, Inc. stated, "We are disappointed that we did not achieve broader statistical significance in this small clinical trial, perhaps due in part to the marked placebo effect noted above.  That said, we at
'/>"/>

SOURCE Ceregene, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs
2. Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011
3. Interleukin Genetics Reports Third Quarter 2011 Financial Results
4. Cell Therapeutics, Inc. Reports Results of Annual Meeting of Shareholders
5. Nile Therapeutics Reports 2011 Third Quarter Financial Results
6. Pharmasset Reports Fiscal Year End 2011 Financial Results
7. Palatin Technologies, Inc. Reports First Quarter Fiscal Year 2012 Results; Teleconference and Webcast to be held on November 15, 2011
8. SeraCare Reports Fiscal Year 2011 and Fourth Quarter Financial Results
9. WaferGen Reports Third Quarter 2011 Financial Results and Announces New Commercialization Strategy
10. Hadasit Bio-Holdings Ltd. Reports Significant External Financing for Portfolio Companies
11. Biodel Reports Fourth Quarter Fiscal Year 2011 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Pa. , Aug. 19, 2014 A ... has been nominated for a Centers for Disease Control ... addressing a major public health concern. ... System, is one of a team of researchers nominated ... Charles C. Shepard Science Award for Data Methods and ...
(Date:8/19/2014)... Research and Markets  has announced the addition ... Strategic Business Report" report to their offering. ... Fuel Cells (SOFCs) in US$ Thousands. The report provides separate ... Europe , Asia-Pacific , ... for the period 2012 through 2020. Market data and analytics ...
(Date:8/19/2014)... XenoTech announces an exclusive partnership with ... from bioactive small molecules. Based on an ... convenient and timely assessment of critical metabolite and ... of Commercial Operations, Christian Darabant, “the value of ... be measured directly by comparison with the approximate ...
(Date:8/19/2014)... GLEN BURNIE, Md. , Aug. 19, 2014 /PRNewswire/ ... the clinical research industry, recently announced the formation of ... is pleased to announce the addition of Dr. ... Photo - http://photos.prnewswire.com/prnh/20140818/136957 ... insight across a variety of therapeutic areas and set ...
Breaking Biology Technology:Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
... and economic development efforts here are taking shape with ... , ,The state is giving Wisconsin Indianhead Technical ... work with local businesses. With the grant, northern Wisconsin ... their workers in industrial maintenance, electrical, supervisory management, and ...
... for fishing enthusiasts may not guarantee you catching "the ... promising spots to cast a lure. , ,A newly ... topographical maps of about 1,000 Wisconsin lakes with global ... ideal fishing locations. The application requires only an Internet ...
... of this article is deliberately misleading. It feeds into ... a bunch of generational tribes engaged in rivalries and ... misunderstandings and tensions among workers born in different eras ... is overblown in my view. , ,Recently, I had ...
Cached Biology Technology:Superior receives funds for technical training 2Online fishing site introduces interactive maps 2Online fishing site introduces interactive maps 3Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 2Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 3Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 4
(Date:8/19/2014)... and Network-Level Science, , Imagine if we had the ... was responding to global changes in real time. Such ... multiple decades of information about ecological responses to environmental ... of different ecosystem types. , In fact, this ... Network, which will soon celebrate its 35th anniversary. , ...
(Date:8/19/2014)... Two Northwestern University scientists have identified a biomarker ... aggressive carcinoma that is resistant to many types ... provides a smart target for new therapeutics designed ... breast cancer patient data taken from The Cancer ... Robert W. Tell used powerful computational and bioinformatics ...
(Date:8/19/2014)... Texas Health Science Center at San Antonio and The ... the awarding of more than $750,000 in grants through ... , Launched in 2003, SALSI is a model of ... health science center join forces for greater research and ... with a focus on public health issues and diseases ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3
... effort led by The Burnham Institute's Gen-Sheng Feng has ... activity in the liver, and generated new findings about ... understanding the pathogenesis of type 2 diabetes. These results, ... made available to the scientific community by advance posting ...
... stem cell lines specifically tailored to match the nuclear DNA ... from disease or spinal cord injury. , The research is ... AAAS, the non-profit science society, on the Science Express website ... the study of human disease in cells in the laboratory. ...
... embryonic stem cell lines specifically tailored to match the nuclear ... suffering from disease or spinal cord injury. , The research ... by AAAS, the non-profit science society, on the Science Express ... enable the study of human disease in cells in the ...
Cached Biology News:Mouse with designer liver has enhanced glucose tolerance, insulin response 2Mouse with designer liver has enhanced glucose tolerance, insulin response 3SuperLigands - a database of ligand structures derived from the Protein Data Bank 2SuperLigands - a database of ligand structures derived from the Protein Data Bank 3SuperLigands - a database of ligand structures derived from the Protein Data Bank 4Scientists generate patient-specific stem cells, Science study says 2Scientists generate patient-specific stem cells, Science study says 3Scientists generate patient-specific stem cells, Science study says 4
... Chemicon Detergent-OUT Kit is a simple high ... solutions. Removes detergents without significant dilution ... protein solution on the Detergent-OUT Spin column ... columns are suitable for removing detergent from ...
... electrophoresis hood is a component ... Placed on the transilluminator, it ... and provides a darkroom environment ... lab bench. This 13 x ...
... Chemicon Detergent-OUT SDS Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... Med columns are suitable for removing ...
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5 mm in ...
Biology Products: