Navigation Links
Centocor Ortho Biotech Receives FDA Complete Response Letter Regarding DOXIL(R) for the Treatment of Advanced Breast Cancer
Date:9/10/2009

se of doxorubicin HCl approaches 550 mg/m2
  • Prior use of other anthracyclines or anthracenediones should be included in calculations of total cumulative dose
  • Cardiac toxicity may also occur at lower cumulative doses (400 mg/m2) in patients with prior mediastinal irradiation or who are receiving concurrent cyclophosphamide therapy
  • Acute infusion-related reactions including, but not limited to, flushing, shortness of breath, facial swelling, headache, chills, back pain, tightness in the chest or throat, and/or hypotension have occurred in up to 10% of patients treated with DOXIL. In most patients, these reactions have resolved within several hours to a day once the infusion is terminated. In some patients, reactions resolved with slowing of the infusion rate
    • Serious and sometimes life-threatening or fatal allergic/anaphylactoid-like infusion reactions have occurred. Medications to treat such reactions, as well as emergency equipment, should be available for immediate use
    • The initial rate of infusion should be 1 mg/min to minimize the risk of infusion reactions
  • Severe myelosuppression may occur
  • DOXIL dosage should be reduced in patients with impaired hepatic function
  • Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis
  • Contraindications

    • Patients with a history of hypersensitivity reactions to a conventional doxorubicin formulation or the components of DOXIL
    • Nursing mothers

    Additional Safety Information

    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to announce ... Lyon County Fair to be held August 5-9 in Marshall. The Ralco Enrichment Center ... come from and how agriculture impacts their daily lives. This unique exhibit also features ...
    (Date:7/30/2015)... CAMBRIDGE, Mass. , July 30, 2015 /PRNewswire/ ... software solutions for the interpretation and analysis of ... Matthew Fischer has joined the company ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... astounding capabilities to integrate, interpret, analyze and explore ...
    (Date:7/30/2015)... ... , ... The 2015 Market Research Report on the Global Propanol Industry ... Propanol market with a focus on the Chinese situation. Major companies included in the ... Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report ...
    (Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative veterinary ... of its canine osteoarthritis stem cell product, currently under development for FDA approval. ... will be marketed in the US by Aratana. This product, termed AT-016, is ...
    Breaking Biology Technology:Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3
    ... Wis. - Another dismal report on venture capital ... the state must do to attract more private equity ... that debate could turn out to be the State ... week's meeting of the investment board, which is the ...
    ... "islands" of green wilderness, increasingly trapped by an expanding ... at the 90th annual Ecological Society of America (ESA) ... development around forests such as the Cleveland National Forest ... or wild "highways" that enable plants and wildlife to ...
    ... Wis. A biologist at the USDA Forest ... for her innovative use of physics technology that has ... processes involved in fungal wood decay, opening the way ... protecting wood, the Forest Products Laboratory has ...
    Cached Biology Technology:State investment board keeps an eye on Wisconsin's tech trends 2State investment board keeps an eye on Wisconsin's tech trends 3Biodiversity threatened as forests become 'islands' of green, UW professor says 2Use of X-rays to advance wood-decay knowledge leads to honor for Forest Products Lab biologist 2
    (Date:7/23/2015)... , July 23, 2015 Research and ... of the "Global Outlook of the Biometrics ... The global biometrics market is ... and commercial applications owing to the uptake of ... a transformation that enhances the growth of biometrics ...
    (Date:7/13/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ... today announced sampling of ClearPad ® 4300, ... (TDDI) product targeting smartphones and tablets. This new ... , best-in-class touch controller IP and systems ... in the company,s Japan Design Center. TDDI enables ...
    (Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
    Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
    ... January 31, 2011 A scientist from The Scripps Research ... molecule in preventing blood clot formation. The molecule could become ... for blood clotting diseases such as Hemophilia A. The ... O. Mosnier, were published in a recent edition of ...
    ... LUNG FUNCTION , New research shows that vitamin ... disease (ILD), with the largest prevalence seen in patients ... University of Cincinnati College of Medicine evaluated vitamin D ... with other forms of ILD. Results showed the overall ...
    ... Building a highway through Serengeti National Park may devastate ... the region,s ecosystem, according to new research by an ... professor. The study by John Fryxell, a Guelph integrative ... States and Canada appears in a recent issue of ...
    Cached Biology News:Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation 2Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation 3Vitamin D deficiency associated with reduced lung function 2Road may disrupt migration, ruin Serengeti, study finds 2