Navigation Links
Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP)

CHAPEL HILL, N.C., May 20, 2013 /PRNewswire/ -- Cempra, Inc. (Nasdaq: CEMP), a clinical-stage pharmaceutical company focused on developing differentiated antibiotics to meet critical medical needs in the treatment of bacterial infections, today announced that it presented data at the American Thoracic Society International Conference (ATS 2013) in Philadelphia demonstrating the antibacterial and enhanced immunomodulatory activity of solithromycin versus levofloxacin in Cempra's prior Phase 2 clinical trial in outpatients with community acquired bacterial pneumonia (CABP). Solithromycin's efficacy profile was comparable to levofloxacin's while solithromycin demonstrated favorable tolerability versus levofloxacin. Solithromycin also demonstrated an enhanced anti-inflammatory response in in vitro studies based on decreased production of inflammatory cytokines and showed re-sensitization to steroids.  The Study, Jamieson et al. (Poster Board # H55) was presented at 8:15 a.m. to 4:30 p.m. EDT, Sunday, May 19.

"Macrolides, such as azithromycin, have been shown to reduce morbidity and mortality in chronic lung diseases such as COPD and diffuse panbronchiolitis," said Prabhavathi Fernandes , Ph.D., president and chief executive officer of Cempra. "The results from this analysis of our Phase 2 clinical trial of oral solithromycin in CABP patients suggest that the comparable early clinical response rates of solithromycin versus levofloxacin may be enhanced by anti-inflammatory properties. Our data provide additional support for our development of solithromycin as a differentiated drug-resistant treatment for CABP and with potential for use in COPD."

About Cempra, Inc.
Founded in 2006, Cempra, Inc. is a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases. Cempra's two lead product candidates are in advanced clinical development; solithromycin in Phase 3 for CABP and TAKSTA™ (CEM-102) in Phase 2 for prosthetic joint infections.  Both seek to address the need for new treatments targeting drug-resistant bacterial infections in the hospital and in the community. The company also intends to use its series of proprietary lead compounds from its novel macrolide library for uses such as the treatment of chronic inflammatory diseases, endocrine diseases and gastric motility disorders. Additional information about Cempra can be found at

Please Note: This press release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially. These risks and uncertainties include, among others:  the results, timing, costs and regulatory review, and other analyses, of our studies and clinical trials; our need to obtain additional funding and our ability to obtain future funding on acceptable terms; our anticipated capital expenditures and our estimates regarding our capital requirements; our ability to obtain FDA approval of our product candidates; our dependence on the success of solithromycin and Taksta; and innovation by our competitors. The reader is referred to the documents that we file from time to time with the Securities and Exchange Commission.

Investor and Media Contacts:

Robert E. Flamm , Ph.D.
Russo Partners, LLC
(212) 845-4226

Andreas Marathovouniotis
Russo Partners LLC
(212) 845-4235


SOURCE Cempra, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. Cempra, Inc. Reports Fourth Quarter and Full Year 2012 Financial and Operating Results
2. Cempra Inc. Presents Additional Data on the Clinical Profile and Activity Spectrum of Solithromycin at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
3. Trigemina Presents at American Pain Society 32nd Annual Scientific Meeting
4. Patheon Exhibits and Presents at the 2013 IQPC Global Formulation and Drug Delivery Summit
5. Upsher-Smith Presents Favorable Phase I Data For USL261, A Novel Formulation Of Intranasal Midazolam, At 65th Annual Meeting Of The American Academy Of Neurology
6. Assemblyman Levine Presents Resolution Recognizing Rare Disease Day at Capitol
7. Drogueria Americana, a Honduran Affiliate of GeneCell International, Presents to a Panel of More Than 100 Leading Dentist on Dental Pulp Stem Cells
8. Cellular Biomedicine Group President Presents Keynote Address at New York Stem Cell Summit
9. Bluestar Silicones Presents Soft Silicone Advantages At Medical Design And Manufacturing (MD&M) West Show
10. Oracle’s Value Chain Summit San Francisco: Track Sponsor NexInfo presents more industry specific solutions
11. Fertility Associates of Memphis, World-Renowned Expert in Infertility, Presents Findings to European Conference
Post Your Comments:
(Date:12/1/2015)... -- Today the Allen Institute announced the opening of ... South Lake Union neighborhood, the city,s biotechnology hub. Located ... Avenue North, the 270,000 square foot life sciences building ... and the Allen Institute for Cell Science. ... Allen Institute. "We started by building a map of ...
(Date:12/1/2015)... Dec. 1, 2015 Frost & Sullivan ... This program addresses ways companies can innovate and ... --> ... --> ... as well as the disrupting factors altering the ...
(Date:12/1/2015)... , Dec. 01, 2015 ... the addition of the "2016 Europe ... Forecasts, Innovative Technologies, Competitive Strategies, Opportunities for ... to their offering. --> ... "2016 Europe Cell Surface Markers: Country ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... its best selling system laboratory animal colony management software solution, ezColony®, is now ... in on-site IT resources., , Many organizations are moving ...
Breaking Biology Technology:
(Date:10/29/2015)... MINNETONKA, Minn. , Oct. 29, 2015   ... that supports the entire spectrum of clinical research, is ... the Minnesota High Tech Association (MHTA) as one of ... in the "Software – Small and Growing" category. The ... and individuals who have shown superior technology innovation and ...
(Date:10/29/2015)... , Oct. 29, 2015 Daon, a global ... it has released a new version of its ... North America have already installed ... also includes a FIDO UAF certified server component ... preparing to activate FIDO features. These customers include some ...
(Date:10/29/2015)... BOSTON , Oct. 29, 2015  Connected health ... phenomena driving the explosion of technology-enabled health and wellness, ... his new book, The Internet of Healthy ... apps, sensors or smartphones even existed, Dr. Kvedar, vice ... model of health care delivery, moving care from the ...
Breaking Biology News(10 mins):