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Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP)
Date:5/20/2013

CHAPEL HILL, N.C., May 20, 2013 /PRNewswire/ -- Cempra, Inc. (Nasdaq: CEMP), a clinical-stage pharmaceutical company focused on developing differentiated antibiotics to meet critical medical needs in the treatment of bacterial infections, today announced that it presented data at the American Thoracic Society International Conference (ATS 2013) in Philadelphia demonstrating the antibacterial and enhanced immunomodulatory activity of solithromycin versus levofloxacin in Cempra's prior Phase 2 clinical trial in outpatients with community acquired bacterial pneumonia (CABP). Solithromycin's efficacy profile was comparable to levofloxacin's while solithromycin demonstrated favorable tolerability versus levofloxacin. Solithromycin also demonstrated an enhanced anti-inflammatory response in in vitro studies based on decreased production of inflammatory cytokines and showed re-sensitization to steroids.  The Study, Jamieson et al. (Poster Board # H55) was presented at 8:15 a.m. to 4:30 p.m. EDT, Sunday, May 19.

"Macrolides, such as azithromycin, have been shown to reduce morbidity and mortality in chronic lung diseases such as COPD and diffuse panbronchiolitis," said Prabhavathi Fernandes , Ph.D., president and chief executive officer of Cempra. "The results from this analysis of our Phase 2 clinical trial of oral solithromycin in CABP patients suggest that the comparable early clinical response rates of solithromycin versus levofloxacin may be enhanced by anti-inflammatory properties. Our data provide additional support for our development of solithromycin as a differentiated drug-resistant treatment for CABP and with potential for use in COPD."

About Cempra, Inc.
Founded in 2006, Cempra, Inc. is a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases. Cempra'
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