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Cempra Inc. Presents Additional Data on the Clinical Profile and Activity Spectrum of Solithromycin at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Date:9/7/2012

i> strains. Solithromycin, a fluoroketolide that has demonstrated activity against other macrolide-resistant pathogens, could be an option to treat some syphilis infections and for treating syphilis in penicillin-allergic patients.  Molini et al., (Abst. #B-1301; 11:15 a.m. to 1:15 P.M. PDT, Tuesday, Sept. 11) tested solithromycin, azithromycin and penicillin G against wild-type and macrolide-resistant strains in a rabbit model.  The latter two compounds are common recommended treatments for syphilis.  The investigators found that solithromycin was as effective in treating wild type syphilis as azithromycin and penicillin G but rabbits infected with strains highly resistant to azithromycin were not cured with solithromycin. 

Additional abstracts presenting data on solithromycin

Pereira D et al., Pikromycin Derivative of Solithromycin: Discussion of Activity.  Abst. #F-1505, 11:15 a.m. to 1:15 P.M. PDT, Tuesday, Sept. 11.  Through molecular modeling of this close analog of solithromycin, Cempra has gained insight about the chemical structures that gives solithromycin its unique ribosomal binding properties.

About CEM-101 (solithromycin)

Solithromycin is the first fluoroketolide with a number of attributes that may provide clinically important advantages over several comparator products:

  • Eight to 16 times more potent than azithromycin and is active against organisms that have become resistant to azithromycin
  • Potent in vitro activity against a broad range of respiratory pathogens, including pneumococci, beta-hemolytic streptococci, staphylococci, Haemophilus, Legionella, Mycoplasma, Moraxella and Chlamydophila
  • Potent in vitr
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SOURCE Cempra Inc.
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