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Celsis Seeks Injunction Against Invitrogen for LiverPool(TM) Patent Infringement

BALTIMORE, June 30 /PRNewswire/ -- Celsis In Vitro, Inc. (Celsis IVT) announced today that it has filed a patent infringement lawsuit against Invitrogen Corporation (Invitrogen) and CellzDirect, Inc. (CellzDirect) in the United States District Court for the Northern District of Illinois in Chicago and has moved for a preliminary injunction.  Invitrogen, the parent of CellzDirect, is itself a wholly-owned subsidiary of Life Technologies of Carlsbad, California.  The complaint alleges that certain processes and methods performed by CellzDirect associated with its in vitro drug testing services and its pooled cryopreserved hepatocyte products infringe one or more claims of U.S. Patent No. 7,604,929 (the '929 patent).  The complaint also alleges that Invitrogen is selling these infringing products and services, as well as inducing infringement of the '929 patent, and seeks monetary damages and injunctive relief.  

Last month, Celsis IVT successfully reached a settlement agreement with XenoTech, LLC, Sekisui Chemical Co. Ltd., and Sekisui Medical Co. Ltd. in a similar patent infringement lawsuit involving the '929 patent.  Celsis is represented by Jordan Sigale and Adam Kelly of Loeb & Loeb LLP.

The '929 patent relates to processes and methods for producing cryopreserved hepatocytes.  In general, this technology combines hepatocytes from multiple donors to create large lots with targeted activity levels, the result of which is a product that speeds up decision making and reduces the time and cost of drug research.  Since 2005, Celsis IVT has used this novel technology to create its unique LiverPool™ products for drug discovery research.  Major pharmaceutical companies around the world have incorporated these LiverPool products into their standard research protocols.  Research conducted with LiverPool has confirmed its outstanding efficacy as a research tool in numerous ADME-Tox assays, including metabolic stability and clearance studies.  Additional LiverPool product information is available online at

"Celsis believes that innovations are the lifeblood of the life sciences industry.  Advancements must be protected and respected if we are to further the cause of cost-effective drug discovery," said Jay LeCoque, CEO of Celsis.  "We are extremely disappointed that we have been forced into this litigation, but the predatory pricing employed by Invitrogen and CellzDirect suggests a serious attempt to erode our patent-protected market position for the LiverPool product line."  He added, "These tactics are lowering, as well as undermining, the perceived value of new product innovations and inventions. We remain hopeful that the defendants will realize the serious impact of such a precedent on the entire life sciences industry, and that they will work with us to properly resolve this issue."

About Celsis IVT

Celsis IVT, a subsidiary of Celsis Holdings, Inc., itself a subsidiary of Celsis International Ltd., is the premier world provider of specialized in vitro products for the study of metabolism, drug-drug interactions and toxicity in drug discovery and development.  Since 1990, pharmaceutical and biotechnology companies have relied on Baltimore-based Celsis IVT for quality in vitro products for lead optimization.  Celsis IVT products deliver faster time to results, enabling more productive and cost-effective research.  Celsis IVT's patented LiverPool products, cryo-plateable hepatocytes (the world's largest inventory) and other ADMET research tools are available worldwide. Visit

About Celsis International Ltd

Chicago-based Celsis International Ltd is a leading global provider of innovative life science products and laboratory services to the pharmaceutical and consumer products industries.  Celsis divisions deliver substantial time and cost savings to customers while ensuring product quality and safety.  Celsis' extensive client base includes leading pharmaceutical and consumer products companies, including the top 25 pharmaceutical companies worldwide. Details at

SOURCE Celsis In Vitro, Inc.
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