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Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes
Date:6/16/2009

l. For example, utilizing the entire liver produces larger lot sizes and, in the case of animals, reduces the number and frequency of animals sacrificed. Thus, cryo-plateable hepatocytes present an ideal system by offering the dual benefits of freshly isolated plateability and the efficiencies of cryopreservation.
  • Reduced Time Delays and Data Variability. As drug manufacturers strive to bring new life-saving drugs to market, time and predictability throughout the R&D process are essential. Even in the early pre-clinical phase, any unpredictability may slow the testing of early investigational compounds by causing scheduling delays that cost the manufacturer lost time and money. In many cases, freshly isolated hepatocytes may not be readily available due to reliance on liver donation which requires staff to remain on call for a liver, and may lead to potential weekend and holiday work. While liver resects from biopsies may improve availability, they are potentially dangerous as they do not include full serology reporting. In contrast, fully characterized cryopreserved hepatocytes can be immediately procured in large inventories and stored at the laboratory, controlling the scheduling of studies and accelerating time to market. Standard induction studies, as an example, typically may be completed 50 percent faster using cryo-plateable hepatocytes.
  • Improved Efficiency. Cryopreserved hepatocytes may be pre-characterized for enzyme activities, genotypes and for applications like induction or transport, representing another major advantage over fresh products. In fact, cryopreserved products may be obtained to meet specific donor requirements while maintaining high levels of viability, confluence or activity. Large inventories and a minimum five-year shelf-life allow researchers to repeat tests at future dates with no difference in product performance. Likewise, research being conducted at multiple sites can dr
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  • SOURCE Celsis International plc
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