Navigation Links
Celsense, Inc Receives NIH Grant to Translate Cell Imaging Technology for Clinical Use
Date:6/2/2009

NIH funds human clinical testing of the cell trafficking MRI reagent, Cell Sense.

Pittsburgh, PA (Vocus) June 2, 2009 -- Celsense, Inc. announced today that it is one of the recipients in a 4-year $1.95M grant from the National Institutes of Health. The funded studies will be the first effort to evaluate Cell Sense, the Company’s fluorocarbon-based magnetic resonance imaging (MRI) cell tracking reagent, for clinical use. Additionally, the studies will garner preliminary data critically important for improving immunotherapeutic delivery strategies in metastatic colorectal (CRC) and other forms of cancer.

The Cell Sense technology makes transplanted cells visible by MRI. Therapeutic cells are labeled ex vivo with the Cell Sense reagent prior to administration to the patient. Cell migration and biodistribution are subsequently monitored using fluorine-19 (19F) MRI or magnetic resonance spectroscopy (MRS). The key advantage of Cell Sense is that the 19F images are extremely selective for the labeled cells, with no background signal from the host’s tissues. Furthermore, accurate cell quantification in regions of interest is possible.

Existing data from pre-clinical studies using human cells show that the Cell Sense reagent is highly biocompatible inside cells and does not affect their innate function. A clinical-grade version of the Cell Sense reagent has been formulated by Celsense, Inc. and is currently being subjected to mandatory in vitro and animal safety studies in preparation for human trials.

To conduct this project, Celsense has partnered with academia, including scientists at Carnegie Mellon University, where the imaging technology was invented in the laboratory of Dr. Ahrens. Also participating is the University of Pittsburgh Cancer Institute (UPCI) which is actively conducting clinical trials using immunotherapeutic dendritic cell (DC) vaccines to treat CRC, directed by Drs. Kalinski and Bartlett.

About Colorectal Cancer (CRC)
CRC is the third leading cancer in the United States and the most common form of gastrointestinal malignancy. CRC accounts for approximately 150,000 new cases annually. Immunotherapeutic interventions using live-cell DC vaccines may potentially be effective in CRC patients. To date, the inability to accurately follow the location of the cells after transfer to the patient is one of the critical bottlenecks in the development and delivery of cancer immunotherapies.

About Cell Sense
Cell Sense (patent-pending) is a fluorocarbon tracer agent used to safely and efficiently label cells ex vivo without the use of transfection agents. Labeled cells are transplanted into the patient enabling researchers and clinicians to non-invasively track the administration and migration of therapeutic and/or diagnostic cells using 19F MRI or MRS. Applications include tracking cells in immunotherapy or regenerative medicine as well as diagnosis of inflammatory sites by tracking selected populations of immune cells. Using software developed by Celsense, investigators can quantify the number of labeled cells in a user-specified region of interest. It is expected that in vivo cellular imaging will routinely be used to provide a surrogate biomarker for certain cellular therapeutic and drug trials.

About Celsense, Inc.
Celsense, Inc. is a biotechnology company offering novel pre-clinical and clinical-grade cellular and molecular imaging agents used to non-invasively monitor biological processes in living systems. The core innovations of the Company involve proprietary imaging agents that can be used to observe the trafficking of cells using magnetic resonance techniques. Celsense’s mission is to be the standard for cellular imaging in human health. For more information, see Celsense.com.

Information Contact: Charlie O’Hanlon, President and CEO of Celsense, Inc.

###

Read the full story at http://www.prweb.com/releases/Celsense/2009-6-1/prweb2483234.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved  

Related biology technology :

1. Mylan Receives Tentative FDA Approval for Generic Version of Singulair(R)
2. 500th Patient Receives Berlin Heart EXCOR Pediatric Ventricular Assist Device
3. SyntheMed Receives Australian Regulatory Approval for REPEL-CV(R)
4. Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients
5. Sanofi Pasteur Receives Seed Virus to Produce New Influenza A(H1N1) Vaccine
6. Genaera Receives Non-Compliance Notice from Nasdaq
7. AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support
8. Catalyst Pharmaceutical Partners Receives NASDAQ Deficiency Notice
9. NeurogesX Receives European Commission Approval for Qutenza(TM)
10. deCODE Genotyping Laboratory Receives College of American Pathologists Accreditation
11. GenVault Receives Four Critical U.S. and E.U. Patent Allowances for Key Biosample Management Technologies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celsense, Inc Receives NIH Grant to Translate Cell Imaging Technology for Clinical Use
(Date:5/27/2016)... ... ... Weeks after hosting a carpal tunnel syndrome workshop with Dr. Oz on the ... the Fitzmaurice Hand Institute, has announced the addition of MRI diagnostic imaging services on ... 1 of about 3 currently available in the United States. Developed specifically for the ...
(Date:5/27/2016)... ... May 27, 2016 , ... Doctors in Italy, Japan, the UK ... the BRCA-1 associated protein (BAP1) gene and its link to malignant mesothelioma. Surviving Mesothelioma ... to read the full article now. , The studies analyzed for the new ...
(Date:5/27/2016)... May 27, 2016 At present, the ... in this space know that volatility is what makes this ... on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), ... (NASDAQ: LPTN ), and Heat Biologics Inc. (NASDAQ: ... to the technical alerts for these stocks at: ...
(Date:5/26/2016)... ISELIN, New Jersey and ... -- Indegene ( http://www.indegene.com ), a ... solutions to life science, pharmaceutical and healthcare organisations ... provider of innovative scientific support throughout the product ... alliance with the launch of IntraScience. ...
Breaking Biology Technology:
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
Breaking Biology News(10 mins):