Navigation Links
Cellular construction methods emulated
Date:3/5/2008

This release is available in German.

Not only is our body made of individual organs, our cells themselves are made of tiny organelles, a variety of separate compartments that fulfill different tasks. Such functional, nanostructured systems would also be useful for technical applications, such as biosensors, self-repairing materials, optoelectronic components, or nanocapsules. However, it has not been possible to recreate structures with sufficient complexity in the lab. Researchers in the Netherlands, led by Jan van Esch at the Universities of Delft and Groningen as well as the BioMaDe Technology Foundation, are now pursuing a new angle. As they report in the journal Angewandte Chemie, they allow surfactants and gelators to form aggregates. These aggregates coexist without interfering with each other and thus make versatile, highly complex structures with separate compartments.

Cells contain various components, such as channels, motors, structural frameworks (cytoskeleton), and power plants (mitochondria). In order for these to form, their building blocks, mainly proteins and lipids, must recognize each other and form the correct assembly by self-aggregation. In addition, it is critical that compatible components do not separate into different phases: when proteins fold, the water-loving (hydrophilic) and water-repellent (hydrophobic) parts of the molecule stay far away from each other and aggregate with like-minded components. Biomembranes are formed when many small lipid molecules aggregate such that their hydrophobic tails face inward together and their hydrophilic heads point outward toward the aqueous medium.

The Dutch team imitated this concept by using two types of self-aggregating compounds: surfactants and gelators. Like the lipids in natural membranes, surfactants have a hydrophilic segment and a hydrophobic segment and aggregate into structures such as membrane-like double layers or vesicles (bubbles). To imitate the forces involved in protein foldinghydrogen-bridge bonds and hydrophobic interactionsthe team used a disk-shaped gelator, in which hydrophobic and hydrophilic molecular components alternate in concentric rings. Just as for proteins, like attracts like. This causes the disks to stack together into columns, which forms long fibers, generating a three-dimensional network in the solution to make a gel.

The researchers allow their surfactants and gelators to aggregate together. In this process, the different components take no notice of each other. This independent formation of different supramolecular structures within a single system is called orthogonal self-aggregation. This results in the formation of novel, complex, compartmentalized architectures, for example, interpenetrating but independent networks or vesicle configurations that coexist with gel fibers.


'/>"/>

Contact: Jan van Esch
j.h.vanesch@tudelft.nl
31-152-788-826
Wiley-Blackwell
Source:Eurekalert  

Related biology technology :

1. First Live U.S. Demonstration of Cellvizio GI In Vivo Cellular Imaging Technology to Occur at Johns Hopkins Conference
2. Chris Tihansky Appointed President of In Vivo Cellular Imaging Leader Cellvizio Inc.
3. National Stem Cell Holding Announces Patent Application for Newly Discovered Cellular Derived Biomaterials for Anti-Aging Applications
4. EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference
5. Intra-Cellular Therapies Provides Overview of its Proprietary Portfolio of Compounds for the Treatment of Female Sexual Dysfunction (FSD)
6. Enerkem announces progress on construction of Canadas first cellulosic ethanol plant
7. DNA is blueprint, contractor and construction worker for new structures
8. White Paper Details Infection Control Challenges Hospitals Must Address During Construction
9. China-Biotics, Inc. Receives Approval to Begin Construction on Large-Scale Manufacturing Facility
10. TEI Biosciences Launches SurgiMend(TM) Collagen Matrix for Soft Tissue Reconstruction
11. Total Site Solutions Selected to Provide Construction Management Services for Existing Pharmaceutical and Biotech Customer for Data Center Expansion Project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cellular construction methods emulated
(Date:5/23/2016)... (PRWEB) , ... May 23, 2016 , ... ... building management solutions and services based in Aurora, Ohio, has broken ground on ... business in the Research Triangle Park area, this new location solidifies a commitment ...
(Date:5/20/2016)... ... 2016 , ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ., ... over 100 of their own patients with the VetStem Cell Therapy. Each of these ... for their patients. , The veterinarians are Dr Ross Rich former owner of ...
(Date:5/20/2016)... ... May 20, 2016 , ... The recent recall by ... reported by Food Safety News on May 12, 2016(1), demonstrates the need for faster ... CEO of Baltimore-based biotech firm, PathSensors, Inc. , PathSensor’s latest solution ...
(Date:5/19/2016)... 2016 There is no saying ... the relentless pressures in pricing and lack in consumer ... circle though - numerous opportunities are up for grabs ... ActiveWallSt.com,s presents four names in this sector: Portola Pharmaceuticals ... (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
Breaking Biology Technology:
(Date:3/15/2016)... -- Yissum Research Development Company of the Hebrew ... Hebrew University, announced today the formation of Neteera ... human biological indicators. Neteera Technologies has completed its first ... ... emissions from sweat ducts, enables reliable and speedy biometric ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
(Date:3/8/2016)... , March 8, 2016   Valencell ... technology, today announced it has secured $11M in ... GII Tech, a new venture fund being launched ... additional participation from existing investors TDF Ventures and ... funds to continue its triple-digit growth and accelerate ...
Breaking Biology News(10 mins):