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Cellular Dynamics and Coriell Institute for Medical Research Awarded Multi-Million Dollar Grants from California Institute for Regenerative Medicine to Manufacture and Bank Stem Cell Lines
Date:3/21/2013

MADISON, Wis., March 21, 2013 /PRNewswire/ -- Cellular Dynamics International (CDI) and Coriell Institute for Medical Research today announced receiving two multi-million dollar grant awards from the California Institute for Regenerative Medicine (CIRM).

CIRM awarded CDI $16 million to create 3 induced pluripotent stem cell (iPSC) lines for each of 3000 healthy and diseased donors. Tissue samples will be taken from patients suffering from Alzheimer's disease, autism spectrum disorders, liver diseases, cardiovascular diseases, neurodevelopmental disabilities such as cerebral palsy and infantile epilepsy, diseases of the eye, or respiratory diseases. CDI will generate the iPSCs using the episomal, or footprint-free, reprogramming method first developed by CDI.

In addition, CIRM awarded Coriell Institute almost $10 million to set up and biobank the iPSC lines, of which CDI will be the primary subcontractor. Coriell Institute will establish a biorepository with proven methods for managing sample collection and tracking, safe storage, and capabilities for worldwide distribution of iPSCs generated by CDI.

CIRM was established to accelerate stem cell research in California by the establishment of a $3 billion fund approved by taxpayers. The most recent initiative earmarked $32.3 million for human iPSC initiatives, including tissue sample collection, iPSC derivation, and biobanking. This initiative will establish a state-of-the-art iPSC bank in California that will be broadly accessible by researchers worldwide.

Induced pluripotent stem cell lines can be created from any individual, and thus provide a powerful tool for studying genetic variation between individuals as well as understanding disease. Patient samples will be collected primarily from standard doctor's office blood draws; CDI pioneered the technique to create iPSCs from blood. iPSCs have the potent
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SOURCE Cellular Dynamics International, Inc.
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