Navigation Links
Cellular Dynamics International Scientists Report on Efficient Method to Produce Footprint-Free Induced Pluripotent Stem Cells (iPSCs) Under Feeder-Free Conditions
Date:3/4/2011

MADISON, Wis., March 4, 2011 /PRNewswire/ -- Cellular Dynamics International (CDI), the world's largest producer of human tissue cells for drug discovery and safety testing, today announced the publication of research demonstrating an efficient and scalable method of creating DNA integration-free, or footprint-free, induced pluripotent stem cells (iPSCs) under a feeder-free condition using chemically defined media.  This method, published on March 1 in PLoS ONE, will likely be valuable for the production of clinical-grade human iPSCs.

Junying Yu, Senior Director, Advanced Development Programs, and lead author of the paper, and her colleagues at CDI improved efficiency over her previously published method that resulted in exogenous DNA-free iPSCs by employing a cocktail containing four small molecules and cultured in chemically defined media free of feeder cells.  The addition of small molecules significantly improved episomal reprogramming efficiency.  Elimination of feeder cells and the use of chemically defined media for both the derivation and culture of footprint-free iPSCs bring the reprogramming technology one step closer to clinical applications.  In addition, the feeder cells represent a source of variability.  Eliminating feeder cells makes the process more amenable to industrialization.  The method was successfully applied and optimized for several cell types including human skin fibroblasts, adipose tissue-derived cells and cord blood cells.

"This publication underscores CDI's commitment to industrialized human biology," said Dr. Yu. "This method enables efficient, safe, large scale derivation of iPSCs for research applications and sets the stage for potential clinical use in the future."

"I wish to congratulate Dr. Yu on her most recent p
'/>"/>

SOURCE Cellular Dynamics International, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. ChanTest to Highlight the Worlds Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Assays & Cellular Targets Conference, Booth 11
2. MaxCyte Debuts the STX Scalable Transfection System at the A/C/T Assays & Cellular Targets Meeting
3. Orange and Medic4all Launched the Worlds First Cellular Tele-Health Service
4. Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia
5. MIT, BU engineer cellular circuits that count events
6. New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the Worlds Leading Bioenergetics Researchers
7. Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement
8. iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming
9. Cellular Dynamics International Reprograms Blood Cells into Stem Cells
10. Cellular Dynamics International In-Licenses Key Patent Portfolio for Using Stem Cell-Derived Cells in Drug Testing
11. Junying Yu, Leading Stem Cell Researcher, Joins Cellular Dynamics International
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... Capillus, LLC announces plans to expand ... Europe and Asia. The Miami-based medical device manufacturer ... Business Development Director of Svenson Group Europe, as ... professional achievements include increasing the number of Svenson ... the Portuguese marketplace with centers in Lisbon and ...
(Date:4/16/2015)... OncoTAb, Inc., a ... spin-out company, announced today the appointment of physician ... Chief Operating Officer (COO). Cooper brings to OncoTAb ... clinical diagnostic and biotechnology platforms in the fields ... extensive career transcends the field of medical and ...
(Date:4/16/2015)... 2015 /CNW/ - Bioenterprise Corporation is pleased to announce that ... Charlottetown , PEI.  Bioenterprise has established a ... Council for the commercialization of agricultural technologies and innovations. ... PEI ADAPT.  They have been at the heart of ... explains Dave Smardon , President & CEO of ...
(Date:4/16/2015)... SAN DIEGO , April 16, 2015 ... company dedicated to improving cancer surgeries, announced today that ... lead fluorescent cancer illuminator, AVB-620, in women with primary, ... trial, the company also welcomed the addition of ... affairs. The open label, dose escalation study ...
Breaking Biology Technology:Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2OncoTAb Names Dr. David L. Cooper as COO 2Bioenterprise Corporation Expands into the Maritimes 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3
, , , , back to top...
... Ltd., The Lord Zuckerman,Research Centre, Whiteknights, PO Box 234, Reading RG6 6LA, UK , ... Introduction , One of ... modified organisms (GMOs) in agriculture and food ... Europe, for clear labeling of products , ...
... Keith Hamby, and Larissa Tan, Bio-Rad Laboratories, , ... , , ... for real-time monitoring , of the polymerase chain reaction ... assay (PE Biosystems), which capitalizes on the 5' exonuclease , ...
Cached Biology Technology:The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 2The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 3The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 4The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 5The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 6The iCycler iQ Detection System for TaqMan Assays, Rev B 2The iCycler iQ Detection System for TaqMan Assays, Rev B 3The iCycler iQ Detection System for TaqMan Assays, Rev B 4The iCycler iQ Detection System for TaqMan Assays, Rev B 5The iCycler iQ Detection System for TaqMan Assays, Rev B 6
(Date:4/6/2015)... OXFORD, Conn. , Apr. 6, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/143028 for ... CLOSE-PROXIMITY COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces ... wireless payments. This patent surrounds the use of ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
(Date:4/2/2015)... 2015 Fingerprint Cards (FPC) has ... from the distributor World Peace Industrial Group (WPI), part ... although the major part of the shipments will take ... by smartphone manufacturers in China . ... the communicated revenue guidance of + 1 000 MSEK for ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... promise for significantly reducing vascular aging by inactivating TNFa, ... cell death. The related report by Csiszar et ... in the January issue of The American Journal of ... heart attack and stroke, occur naturally, even in otherwise ...
... Investigators at St. Jude Children's Research Hospital have discovered ... bacteria can cause fatal heart damage; researchers have also ... by increasing the number of cell wall pieces shed ... mouse model how to prevent this from happening. , ...
... Todd Lane and Victoria VanderNoot have been awarded ... can successfully detect deadly toxins from harmful algal ... Cooperative Institute for Coastal and Estuarine Environmental Technology ... Atmospheric Administration (NOAA) and the University of New ...
Cached Biology News:A new jump start for aging blood vessels 2Cell wall of pneumonia bacteria can cause brain and heart damage 2Cell wall of pneumonia bacteria can cause brain and heart damage 3Sandia research to focus on early detection of harmful algal blooms 2Sandia research to focus on early detection of harmful algal blooms 3
... Convenient platform for tube handling and reagent dispensing ... tubes - 96 x 0.3ml U-bottom ... - Thermo-Fast® 96 Non-Skirted Plate - ... x 0.5ml Thermo-Tubes Multiple workstations can be securely stacked ...
... well Magnetic-Ring Stand is designed for paramagnetic ... microplates. The stand has a plastic base ... plate footprint. The use of 96 extremely ... easy magnetic separation. With this magnetic stand, ...
... • Enzyme concentration - 5 units/µL ,• ... higher yields ,• Leaves an 'A' overhang ... polymerase which exhibits very high activity in ... To ensure the quality of the enzyme, ...
Taq DNA Polymerase (T. aquaticus), 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzyme...
Biology Products: