Navigation Links
Cellectis Sues Precision BioSciences for Infringement of its Patents Concerning Meganuclease Technology
Date:3/13/2008

BIOCITECH PARK, ROMAINVILLE, France, March 13 /PRNewswire-FirstCall/ -- Cellectis SA (NYSE: ALCLS), a world leader in rational genome engineering, has announced today that it filed a patent infringement lawsuit against Precision BioSciences, Inc. in the United States District Court for the Eastern District of North Carolina. The lawsuit seeks a declaration that, by making and selling certain meganucleases, Precision BioSciences infringes two Cellectis patents relating to its proprietary meganuclease recombination systems. The Precision Biosciences' meganucleases at issue are intended to target site-specific DNA breaks and effect a desired genome modification in a given transgenic organism, such as a plant. The lawsuit seeks both monetary damages for infringement, as well as a permanent injunction preventing Precision BioSciences from any further making, using or selling of such meganucleases. "We take our intellectual property rights very seriously and intend to vigorously pursue this patent infringement case," said Dr. Andre Choulika, CEO and co-founder of Cellectis SA., and the man who participated in coining the term "meganuclease."

Since its creation in January 2000 and throughout its development, Cellectis has made special efforts to protect new discoveries made by its research team as well as those of its partner, the world-renowned Institut Pasteur. Cellectis currently owns the exclusive rights to over 35 issued patents and 113 pending patent applications. Most of these patents are based on Cellectis' fully integrated genome engineering system referred to as its Meganuclease Recombination Systems (MRSs). These systems offer natural, efficient, precise and flexible genome surgery with several applications, among others, in the therapeutic area and in the plant science field.

About Cellectis

Cellectis SA (http://www.cellectis.com) is a world-leading company in genome engineering and genome surgery. The company is focused on developing and producing custom meganucleases for in vivo DNA surgery and also provides new tools for rational reverse genetics and targeted recombination. Cellectis' products induce unique, site-directed, double-strand DNA breaks in living cell and can be used in a wide range of biotechnological and therapeutic applications.

A strong Patent portfolio

Cellectis holds exclusive rights to 148 patents and patent applications providing the company with a strong position in the field of homologous recombination (3 issued US patents) and meganucleases and uses thereof (18 issued US patents) both naturally-occurring and with engineered specificity. A significant part of this patent portfolio has been exclusively licensed by Institut Pasteur, which spun off the company in 2000.

Institut Pasteur, thanks to its work with pioneering groups in the filed, has a long history in the exploitation of methods of homologous recombination, a major scientific breakthrough (Nobel Prize 2007) and is today the assignee of cornerstone patents from the late 80's. Finally the team, which discovered meganucleases and published founding works on the I-SceI homing endonucleases leading to the constitution of the Cellectis proprietary patent portfolio, is from Institut Pasteur.

A strong scientific background

Teams involved in the discovery of meganucleases at Institut Pasteur and Cellectis have published tens of cornerstone publications in prestigious peer-review papers such as Cell, Nature, Science, PNAS, JBC or JMB. For the sole year 2007, Cellectis has published 5 important scientific publications in peer-review journals and 2 papers since the beginning of 2008.

A technology that delivers

Cellectis currently holds a portfolio of 18 meganucleases with modified specificity, deriving from the I-CreI meganuclease with applications in:

- Healthcare, Therapeutics - major indications are severe innate genetic diseases, DNA virus infectious diseases, transplantation and Cancer

- Agricultural biotechnology - major targets are seed improvements, biofuels and biofibers

- BioProduction - major indications are cell line and recombinant protein improvements

- BioTools - a major indication is the development of research kits for pharmacogenomic studies and in particular drug screening

A partner oriented strategy

The company has signed 48 partnerships with pharmaceutical companies (Astra-Zeneca, GSK, Shire), agricultural biotechnology groups (Limagrain, Bayer, BASF, DuPont-Pioneer HiBred) and biotech companies (Genentech, Transgenics, Lexicon). Cellectis contributes to over 20 academic partnerships including Institut Gustave Roussy cancer research centre, Paris Childrens Hospital (France), Boston Childrens Hospital or Harvard Gene Therapy Initiative (USA).

Financing

The company raised above EUR24m in an IPO on NYSE Euronext Alternext (February 2007) to increase its meganucleases production capacity to 20 products a year by the end of 2008. To date the company has raised over EUR40m both in private and public rounds.

Cellectis is listed on the NYSE Euronext Alternext market (ticker code: ALCLS). For more information on Cellectis, visit our web site: http://www.cellectis.com.

Cellectis' Forward-Looking Statements

This communication expressly or implicitly contains certain forward-looking statements concerning Cellectis SA and its business. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of Cellectis SA to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Cellectis SA is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise. For a discussion of risks and uncertainties which could cause actual results, financial condition, performance or achievements of Cellectis SA to differ from those contained in the forward-looking statements please refer to the Risk Factors (Facteurs de Risque) section of the prospectus approved by the French Autorite des Marches Financiers ("AMF") on January 22nd, 2007 under visa number 07-023, available on the websites of the AMF ( http://www.amf-france.org) and Cellectis (http://www.cellectis.com)


'/>"/>
SOURCE Cellectis SA
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Varian Medical Systems Exhibits Latest Technologies and Products Designed to Improve Speed and Precision of Radiotherapy at ESTRO 2007
2. DuPont and Precision BioSciences Collaborate to Accelerate Crop Product Development
3. Time Domain Showcases Precision Location Capability of Ultra Wideband PLUS Product Line at HIMSS 2008
4. YM BIOSCIENCES ANNOUNCES COMPLIANCE WITH AIM RULE 26
5. Selection of Development Candidate Triggers $0.5 Million Milestone Payment to Ardea Biosciences, Inc.
6. ImmuneRegen BioSciences Files 8-K that Highlights Enclosed Shareholder Letter Discussing Recent Achievements and Outlook
7. ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB
8. Pressure BioSciences, Inc. Reports Second Quarter 2007 Financial Results and Provides Business Update
9. YM BIOSCIENCES, EUROPEAN PARTNER, ONCOSCIENCE AG, ANNOUNCES INITIATION OF ADVANCED NIMOTUZUMAB TRIALS IN ADULT GLIOMA AND PANCREATIC CANCER
10. Monogram Biosciences to Present at the Thomas Weisel Partners Healthcare Conference 2007
11. Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Eurofins announces the appointment of Sean Murray , National Division ... Mr. Murray will bring valuable expertise to the ... leading international business teams. As the National Division Leader, he will ... status as the global leader in bio-analytical testing services. ... , , ...
(Date:12/8/2016)... December 8, 2016 Oxford Gene ... customisable SureSeq™ NGS panel range with the launch of the ... cost-effective study of variants in familial hypercholesterolemia (FH). The panel ... detection on a single small panel and allows customisation by ... includes all exons for LDLR , P ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... World Technology Awards. uBiome is one of just six company finalists in the ... In addition to uBiome, companies nominated as finalists in this year’s awards include ...
(Date:12/8/2016)... Dec. 8, 2016  HedgePath Pharmaceuticals, Inc. (OTCQX: ... develops and plans to commercialize innovative therapeutics for ... common stock were approved for trading on the ... on the OTCQX, effective today, under the ticker ... OTCQX market, companies must meet high financial standards, ...
Breaking Biology Technology:
(Date:11/29/2016)... 2016   Neurotechnology , a provider ... technologies, today released FingerCell 3.0, a software ... that run on low-power, low-memory microcontrollers. FingerCell ... than 128KB of memory, enabling it to ... limited on-board resources, such as: mobile phones, ...
(Date:11/24/2016)... 23, 2016 Cercacor today introduced Ember TM ... trainers non-invasively measure hemoglobin, Oxygen Content, Oxygen ... Respiration Rate in approximately 30 seconds. Smaller than a ... immediate access to key data about their bodies to ... regimen. Hemoglobin carries oxygen to muscles. ...
(Date:11/21/2016)... , Nov. 21, 2016   Neurotechnology , ... recognition technologies, today announced that the MegaMatcher On ... was submitted for the NIST Minutiae Interoperability ... all the mandatory steps of the evaluation protocol. ... a continuing test of fingerprint templates used to ...
Breaking Biology News(10 mins):