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Celladon Corporation and SIRO Clinpharm Announce Presentation at "Statisticians in the Pharmaceutical Industry International Conference"
Date:5/8/2013

SAN DIEGO, May 8, 2013 /PRNewswire/ -- Celladon Corporation, a biopharmaceutical company focused on the discovery and development of innovative treatments for cardiovascular diseases, announced today that it will present analysis methods for  the MYDICAR development program at an upcoming Conference.

The conference "Statisticians in the Pharmaceutical Industry International Conference" is being held in Glasgow, UK, on 12-15 May, 2013

  • "Analysis of Recurrent Heart Failure Hospitalizations in Presence of Informative Censoring" – Application of Joint Frailty Model  by Alex Yaroshinsky (Celladon Corporation); Ladislav Pecen (SIRO Clinpharm); and Alena Cernikova (SIRO Clinpharm)

"This conference presentation represents additional recognition of Celladon's innovative approach to the MYDICAR development program, and has many benefits over traditional analysis methods including reduced sample size relative to other heart failure trials," said Krisztina Zsebo Ph.D., President and CEO of Celladon Corp.  "It is the first time the U.S Food and Drug Administration has accepted the use of this statistical analysis method as part of a primary endpoint in a clinical trial for the treatment of heart failure," continued Dr. Zsebo.

About MYDICAR

MYDICAR is a genetically targeted enzyme replacement therapy intended to restore levels of SERCA2a, a regulator of calcium cycling in the heart and cardiac contractility. SERCA2a levels decline in all forms of late-stage HF resulting in deficient heart function. With MYDICAR, the SERCA2a gene is delivered using recombinant adeno-associated virus (AAV) as the vector. AAV is a naturally occurring virus not associated with any disease in humans. MYDICAR is delivered in a single dose directly to the heart during a
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SOURCE Celladon Corporation
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