Navigation Links
Celladon Corporation Announces Pre-clinical Study Demonstrating Inhalable MYDICAR Reverses Pulmonary Arterial Hypertension (PAH)
Date:7/30/2013

ism, when clots in the legs travel to the lungs and cause blockages. When the lung is damaged from these conditions, the tissue starts to quickly produce new and enlarged cells, which narrows pulmonary arteries. This increases the pressure inside them. The high pressure in these arteries resists the heart's effort to pump through them and the blood flow between the heart and lungs is reduced. The right side of the heart then must overcome the resistance and work harder to push the blood through the pulmonary arteries into the lungs. Over time, the right ventricle becomes thickened and enlarged and heart failure develops.

The MYDICAR gene therapy that Dr. Hajjar developed uses a modified adeno-associated viral-vector (AAV-vector). It works by introducing a healthy SERCA2a gene into cells, but this gene does not incorporate into a patient's chromosome, according to the study's lead author, Lahouaria Hadri, PhD, an Instructor of Medicine in Cardiology at Icahn School of Medicine at Mount Sinai. "The clinical trials in congestive heart failure have shown already that the gene therapy is very safe," says Dr. Hadri.

The clinical application of MYDICAR for patients with PAH will differ from those with heart failure. When treating heart failure patients, MYDICAR is infused through the coronary arteries of heart failure patients using catheters, while in PAH patients, MYDICAR will need to be administered through inhalation.

This study was supported by National Institutes of Health grants (K01HL103176, K08111207, R01 HL078691, HL057263, HL071763, HL080498, HL083156, and R01 HL105301).

About MYDICAR in Heart Failure
MYDICAR is a genetically targeted enzyme replacement therapy intended to restore levels of SERCA2a, a regulator of calcium cycling in the heart and cardiac contractility. SERCA2a levels decline in all forms of late-stage HF resulting in deficient heart function. With MYDICAR, the SERCA2a gene is delivered using recombinant adeno-a
'/>"/>

SOURCE Celladon Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Celladon Corporation Named a 2012 Fierce 15 Company by FierceBiotech
2. Celladon Corporation To Present at BioCentury Future Leaders in the Biotech Industry Conference
3. Celladon Corporation and SIRO Clinpharm Announce Presentation at "Statisticians in the Pharmaceutical Industry International Conference"
4. Celladon Corporation Selected as Winner of Red Herrings "Top 100 North America Tech Startup"
5. China Cord Blood Corporation to Report Second Quarter and First Half of Fiscal 2012 Financial Results
6. Kensey Nash Corporation Announces Achievement of $6 Million Milestone From Spectranetics Corporation
7. China Cord Blood Corporation Announces Results of 2011 Annual General Meeting
8. Neogen Corporation Announces 2nd Quarter Results Conference Call
9. Luminex Corporation to Present at JP Morgan Healthcare Conference
10. Luminex Corporation Fourth Quarter and Full Year 2011 Earnings Release Scheduled for February 6, 2012
11. Plaintiff Sales Representatives and Novartis Pharmaceuticals Corporation Resolve Class Action Wage and Hour Claims
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Transparency Market Research, in its report titled ... by Application - Cancer, Metabolic, CVS, CNS & others, ... - Global Industry Analysis, Size, Share, Growth, Trends and ... therapeutics market was worth US$14.1 billion in 2011 and ... an 8.7% CAGR. , The two main types of ...
(Date:9/29/2014)... METTLER TOLEDO’s new line of XPE ... precision balances as well as automated dosing ... can carry out their daily weighing tasks worry free, ... deliver consistently reliable and compliant results, thanks to new ... of the biggest challenges in analytical and micro-analytical weighing ...
(Date:9/29/2014)... ANGELES , Sept. 29, 2014 ... biopharmaceutical research and development company specializing in oncology, ... Administration (FDA) has granted multiple Orphan Drug Designations ... three indications: glioblastoma multiforme (GBM), small cell lung ... version of the widely-used chemotherapeutic agent, doxorubicin. ...
(Date:9/27/2014)... in the peer-reviewed Journal of Animal Science ... crops has no impact on the health or productivity ... literature and field data sets, the article documents evidence ... GE crops are comparable with those of animals fed ... GE feed crops have become an increasing component of ...
Breaking Biology Technology:Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3New Line of XPE Balances from METLER TOLEDO is Designed for High Performance and Ease of Compliance 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 2CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 3CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 4CytRx Receives Multiple FDA Orphan Drug Designations for Aldoxorubicin for the Treatment of Glioblastoma, Small Cell Lung Cancer and Ovarian Cancer 5
... MILWAUKEE - Miller Brewing Co. ... its sourcing processes, consolidate purchases across six U.S. ... those processes, Procuri announced. , ,Procuri, ... such as Blue Cross and Blue Shield Association, ...
... from the University of Wisconsin-Madison and an international consortium ... the first astronomical images obtained by the Southern African ... to the largest optical telescope in the world. , ... built the telescope on a remote mountain plateau, 220 ...
... Wis. -- One of the greatest agricultural and evolutionary ... the answer may lie in a plot of corn on ... new life to ancient genetic material. , ,While many biologists ... of maize, others believe that the differences between teosinte and ...
Cached Biology Technology:Single gene controls key difference between maize and its wild ancestor 2Single gene controls key difference between maize and its wild ancestor 3
(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
(Date:9/29/2014)... Mountain pine beetles get a bad rap, and ... pine trees over tens of millions of acres in ... , But contrary to popular belief, these pests ... like those that have recently swept through the region. ... the ecological severity of fires than these bark-boring beetles. ...
(Date:9/29/2014)... published online in Behavioral Brain Research provides ... as a result of chronic alcohol exposure that can ... Clinical assessments and research indicate that individuals with alcohol ... can occur when people are actively drinking, when they ... , "Sleep-wake disturbances can last for months, or ...
Breaking Biology News(10 mins):Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... As health professionals search for ways to combat the rise ... mother,s own eating habits and whether she views her ... on whether her child consumes enough fruits and vegetables. ... University,s College of Nursing looked at nearly 400 low-income women ...
... count, and that certainly holds true for the channels ... or molecules of a certain size to pass through, while ... capabilities of transmembrane proteins are highly prized for a number ... individual artificial channels of this size until now. ...
... Australia,s swamp bottlebrush, flowering plants are everywhere. Also ... land-based, plant life. New research published this week ... Sciences provides new insights into their genetic origin, ... diverse flowering plants more than 130 million years ago. ...
Cached Biology News:Mothers' diets have biggest influence on children eating healthy 2Tiny channels carry big information 2Tiny channels carry big information 3What 'pine' cones reveal about the evolution of flowers 2What 'pine' cones reveal about the evolution of flowers 3