Navigation Links
Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity
Date:9/1/2009

he clinic in 2010."

About Intercept Pharmaceuticals

Intercept is a clinical stage biopharmaceutical company focused on discovering and developing small molecule drugs for the treatment of chronic fibrotic and metabolic diseases. The company's most advanced programs are focused on the development of modified bile acids that are selective for FXR, a nuclear receptor, and TGR5, a G protein-coupled receptor. Bile acid signaling through these receptors regulates key aspects of lipid, glucose and overall energy metabolism, while also serving to maintain the functional integrity of the liver, intestine and kidney, organs that are exposed to bile acid flux.

Intercept's lead compound, INT-747, is a modified human bile acid and first-in-class FXR agonist that is currently in Phase II testing. Clinical proof of concept was recently demonstrated in a Phase II, placebo-controlled trial of INT-747 in type 2 diabetics with fatty liver disease. Based on these results, the company plans to advance INT-747 in a Phase IIb trial in patients with nonalcoholic steatohepatitis (NASH) in 2010. INT-747 is completing two additional Phase II trials in patients with primary biliary cirrhosis, an autoimmune cholestatic liver disease and orphan indication. Results from the first of the two studies are expected in the fourth quarter of 2009.

INT-777 is a modified human bile acid and selective TGR5 agonist that is currently being assessed in IND-enabling studies.

For more information about Intercept, please go to www.interceptpharma.com; and for information about Intercept's lead investor, Genextra S.p.A., please go to www.genextra.it.


'/>"/>
SOURCE Intercept Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. ChartTrends(R): Bone and Mineral Metabolism in Dialysis Reveals Latest Trends in the Treatment of Calcium, Phosphorus and PTH
2. Circulation Publishes MERLIN TIMI-36 Data Showing Safety and Anti-Arrhythmic Effects of Ranexa(R)
3. Thomson Scientific Publishes Who Is Making The Biggest Splash? - A Quarterly Review of Scientific Literature on Drugs and Therapies From April - June 2007
4. Consortium publishes Phase II map of human genetic variation
5. The Lancet Publishes Vasogens ACCLAIM Results
6. Dendreon Publishes Manuscript on CD54 as a Surrogate Marker of Antigen Presenting Cell Activation
7. The Lancet Publishes Results From Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
8. Springer publishes anthology with the Nanoethics Group
9. The Scientific Business of Thomson Reuters Publishes Its 2008 Liquent Regulatory Affairs Trends Survey Results
10. Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in Support of Chinas Ministry of Science and Technology
11. Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2015)... ... 29, 2015 , ... Asymmetrex, LLC founder and ... the full range of capabilities of its unique cache of technologies for identifying, ... day-to-day renewal and repair of normal tissues and organs. This property makes them ...
(Date:7/28/2015)... (PRWEB) , ... July 29, 2015 , ... The new Xsample 530 sample changer ... handles a wide range of liquid viscosities – from less than 12,000 mPas (internal air) ... mL vials. , What immediately catches the eye about Xsample 530 is its removable ...
(Date:7/28/2015)... ... July 28, 2015 , ... ... 1.022 billion in 2013; while production volume reached close to 1.84 million tonnes ... with a share of 75.5% of the region’s total aluminium hydroxide production; the ...
(Date:7/28/2015)... Deerfield Management Company, L.P. today announced the ... will invest in groundbreaking advancements in science that may ... orphan diseases. The venture capital fund will also back ... and improve the way healthcare is delivered to patients. ... venture funds in the sector, will donate all profits ...
Breaking Biology Technology:Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4New Moves in Automatic Sample Handling: Introducing Xsample 530 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3
... MedImmune, Inc. today,announced that it has made ... A. Zukiwski, M.D., senior vice president, clinical,research; ... manufacturing;,and Timothy J. Maines, vice president, corporate ... addition, new executive promotions include,Max Donley, vice ...
... Biomira Inc. (Nasdaq: BIOM ),(TSX: BRA) (the "Company") ... letter from The Nasdaq Stock Market, Inc. ("Nasdaq") notifying,the ... the date of,the letter, the bid price of the ... minimum required for continued inclusion on the Nasdaq,Global Market ...
... 2 Brinks Hofer Gilson & Lione, one ... United States, is pleased to,announce that Meredith Martin ... Group, has been appointed chair of the Amicus ... AIPLA is a national bar association with ...
Cached Biology Technology:MedImmune Announces Seven Key Promotions and New Hires 2MedImmune Announces Seven Key Promotions and New Hires 3MedImmune Announces Seven Key Promotions and New Hires 4MedImmune Announces Seven Key Promotions and New Hires 5Biomira Inc. receives Nasdaq delisting notification 2Biomira Inc. receives Nasdaq delisting notification 3Biomira Inc. receives Nasdaq delisting notification 4Biomira Inc. receives Nasdaq delisting notification 5Meredith Martin Addy Named Chair of AIPLA's Amicus Committee 2
(Date:7/21/2015)... 21, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market ... that it has filed provisional patent 62/192218 for ... This invention highlights next generation payment ... account, but also the user using unique personal ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... 8th, 2011, Shenzhen, China BGI, the world,s largest ... People,s Hospital, announced today that the study on frequent ... (TCC) of the bladder was published online in ... basis for future studies on TCC, suggesting that aberration ...
... A repellant for sea lampreys could be the key to ... the Great Lakes, says a Michigan State University researcher. ... When scents from dead sea lampreys are poured into a ... dramatic. In the past, these reactions were simply dismissed as ...
... demise of the world,s forests some 250 million years ... by global climate change, according to a new study ... Dutch and British colleagues. The researchers do ... could cause a similar increase in pathogenic soil bacteria ...
Cached Biology News:Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder 2Sea lampreys fear the smell of death 2Did past climate change encourage tree-killing fungi? 2Did past climate change encourage tree-killing fungi? 3
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
Incorporating the innovative InGaAs detection system the Cary 6000i is the worlds most advanced UV-Vis-NIR spectrophotometer delivering superior signal to noise performance and outstanding sensitivit...
Biology Products: