Navigation Links
Cell Metabolism Publishes Novel TGR5-Mediated Mechanism for the Treatment of Diabetes and Obesity
Date:9/1/2009

a DPP4 inhibitor such as sitagliptin.
  • INT-777 normalizes glucose tolerance in obese, insulin resistant (DIO) and diabetic (db/db) mice; the treated mice maintain normal insulin levels and glucose uptake in liver and muscle.
  • INT-777 prevents weight gain and fat accumulation in mice on a high fat diet by increasing energy expenditure and fat burning; liver function is also protected with reduced steatosis, fibrosis and serum markers of liver damage in the treated mice.
  • Professor Pellicciari, a co-author on the paper, commented, "Years of concerted discovery efforts and proprietary know-how in bile acid chemistry have resulted in our ability to rationally design molecules that are highly selective for bile acid receptors. The realization of this in the novel TGR5 agonist INT-777 and the characterization of its mechanism of action represent an important milestone in the establishment of a novel class of therapeutic agents targeting this receptor."

    Professor Johan Auwerx, who has led the field in uncovering the role of the TGR5 receptor and representing the lead authors at EPFL, added, "Our collaboration with the joint Intercept-Pellicciari team has been extremely fruitful. We are very pleased with the performance of INT-777, a compound that has allowed us to further elucidate this critical mechanism of TGR5 regulated GLP-1 release in the gut."

    Dr. Mark Pruzanski, founder, President and CEO of Intercept and a co-author on the paper, commented further, "Diabetes, obesity and other associated metabolic disorders are reaching epidemic proportions. At Intercept we are uniquely positioned to exploit the therapeutic potential of modified bile acids, molecules that nature has designed to play a central role in the maintenance of metabolic homeostasis. In this context, TGR5 has emerged as an important target and INT-777 as an excellent candidate that we plan to advance into t
    '/>"/>

    SOURCE Intercept Pharmaceuticals, Inc.
    Copyright©2009 PR Newswire.
    All rights reserved

    Page: 1 2 3

    Related biology technology :

    1. ChartTrends(R): Bone and Mineral Metabolism in Dialysis Reveals Latest Trends in the Treatment of Calcium, Phosphorus and PTH
    2. Circulation Publishes MERLIN TIMI-36 Data Showing Safety and Anti-Arrhythmic Effects of Ranexa(R)
    3. Thomson Scientific Publishes Who Is Making The Biggest Splash? - A Quarterly Review of Scientific Literature on Drugs and Therapies From April - June 2007
    4. Consortium publishes Phase II map of human genetic variation
    5. The Lancet Publishes Vasogens ACCLAIM Results
    6. Dendreon Publishes Manuscript on CD54 as a Surrogate Marker of Antigen Presenting Cell Activation
    7. The Lancet Publishes Results From Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
    8. Springer publishes anthology with the Nanoethics Group
    9. The Scientific Business of Thomson Reuters Publishes Its 2008 Liquent Regulatory Affairs Trends Survey Results
    10. Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in Support of Chinas Ministry of Science and Technology
    11. Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:9/17/2014)... 2014 Immunomic Therapeutics, Inc. announced today ... grant to support the continued preclinical development of a ... approximately $255,000 over one year to conduct vaccine validation ... allergy, affect over one million Americans and are the ... nut exposure is also a risk for peanut allergics, ...
    (Date:9/17/2014)... SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: SQIDF), a life ... products for advanced microarray diagnostics, today announced that its ... the United States on the OTCQX ... 17, 2014 on the OTCQX under the symbol SQIDF.  ... Venture Exchange under its existing symbol SQD. ...
    (Date:9/17/2014)... Escape Alert, LLC . filed international patents for an ... their pet has escaped and enable them to track their pet’s ... body. This is the first implantable microchip with GPS. , ... many years, they are passive until read by scanners, do not ... or alert the owner that the pet has escaped. Escape ...
    (Date:9/16/2014)... September 16, 2014 “Nature has developed, ... features that we desire in optical design,” said Joseph ... State University. “As we explore surfaces and structures at ... lessons were presented in San Diego in August during ... in Nature ” chaired by Shaw and Rongguang Liang ...
    Breaking Biology Technology:Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5
    ... NEW YORK, July 24 American Oriental,Bioengineering, Inc. (NYSE: ... release,second quarter 2008 financial results on Monday, August 11, ... a conference call at 5:00 pm ET on August ... Listeners may,access the call by dialing 1-800-599-9816 or 1-617-847-8705 ...
    ... SOUTH SAN FRANCISCO, Calif., July 24 Poniard,Pharmaceuticals, ... focused,on oncology, today announced that it will hold ... results and provide a corporate update,including an update ... lead product candidate. Jerry McMahon, Ph.D., chairman and ...
    ... July 24 Sagent Pharmaceuticals, Inc.,a privately-held specialty ... for injection, USP, a semisynthetic,broad-spectrum, beta-lactam antibiotic. Sagent ... vials and 6g pharmacy bulk package vials. According ... the United States were,approximately $45.7 million., "Sagent ...
    Cached Biology Technology:Poniard Pharmaceuticals to Host Second Quarter 2008 Financial Results Conference Call on July 31 2Sagent Pharmaceuticals Launches Ceftazidime for Injection, USP 2
    (Date:9/17/2014)... bags and their environmental impact recently scored a major ... ban on the bags, and Governor Jerry Brown is ... is not yielding without a fight, according to an ... weekly newsmagazine of the American Chemical Society. , Alexander ... anti-bag campaign logged its first small victory in 1990 ...
    (Date:9/17/2014)... Copenhagen Centre for Social Evolution and Yale University offers ... weight and -length can partially predict the likelihood of ... and schizophrenia later in life. The study analyzed medical ... diagnoses for up to 30 years, and adjusted for ... published today in the Proceedings of the Royal ...
    (Date:9/17/2014)... Informatics at IMIM (Hospital del Mar Medical Research Institute) ... recently published a study in eLife showing ... in the evolution of new proteins, some of which ... Ribosomes produce proteins from the instructions found in an ... is RNA containing information for the synthesis of proteins, ...
    Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Parts of genome without a known function may play a key role in the birth of new proteins 2
    ... treatment for stroke has taken a major step forward following ... The University of Manchester have shown in laboratory studies that ... injury and death. , The team, led by Professor Nancy ... of the first small trial of IL-1ra in patients, which ...
    ... of diseases , A team of international researchers ... 15 regulates inflammation, a finding with implications for ... disease, diabetes, obesity, Alzheimer's, and infections. The ... issue of Nature Genetics. , Investigators believe this ...
    ... Hopkins researcher, with colleagues in Sweden and at the ... view of cancer as a group of diseases with ... alterations within a cell's nuclear DNA may have to ... January issue of Nature Reviews Genetics, available online Dec. ...
    Cached Biology News:Stroke treatment a step closer after trial 2Scientists pinpoint inflammation gene 2Scientists pinpoint inflammation gene 3Scientists pinpoint inflammation gene 4New view of cancer: 'Epigenetic' changes come before mutations 2
    ... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
    Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
    ... dual parameter assay for mitochondrial membrane ... Active caspases are detected by carboxyfluorescein ... are cell-permeable, non-cytotoxic and bind covalently ... cells. At the same time the ...
    ... Mouse P815 cells were cultured in DMEM ... In order to keep the antigens in ... The cells are arrayed on a 12-well ... surface specifically treated to enhance cellular attachment and ...
    Biology Products: