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Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition
Date:10/11/2011

y Sources

Nutrients

Cell Culture Media

Lysogeny broth (LB)

Classical Media

Serum-free Media

Protein-Free Media

Chemically Defined Media

Specialty Media

Sera

Reagents

Shifting Towards Non-animal Derived Reagents

Addressing Reagent Safety Issues

World Cell Culture Market

Cell Culture Market and Forecast

Current and Future Trends

CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT

Growing Demand for Biopharmaceuticals

Biopharmaceutical Market

Development of Biopharmaceuticals

Biopharmaceutical Product Approvals

Biopharmaceutical Growth Increases Demand for Cell Culture Products

A Brief History of Biotechnology

Science of Genetic Manipulation

From Petri Dish to Biopharmaceutical Upstream Bioprocessing: Cell Culture Expression Systems

Cells for Biopharmaceutical Production

Bacteria and Yeasts Systems

Animal Cell Systems

Insect Cell Systems

Advantages/Disadvantages of Cell Culture Systems

Cell Lines and Cell Banks

Biopharmaceuticals Produced from Cell Culture

Cell Culture Practices and Regulatory Guidelines

Validation of Facilities

Maintaining Sterilization Standards

CHAPTER THREE: CELL CULTURE TECHNOLOGY

Introduction and Overview

Milestones in Cell Culture Development

Cell Lines for Bioproduction

Predominant Cell Lines

Chinese Hamster Ovary (CHO)

SP2/0, and NS0

HEK 293 and PER. C6

Sources: Largest Collections of Cell Lines

Fermentors and Bioreactors

Types of Bioreactors/Fermentors

Stirred-tank Reactors

Airlift Fermentors

Packed Bed Reactors

Hollow-fiber Reactor

Disposable Systems

Fermentation Processes

Batch and Fed-Batch Ferment
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