Navigation Links
Case Western Reserve University-led team takes high resolution photo of a K+ channel
Date:7/13/2010

of this study provide support for a newly proposed gating mechanism of the K+ channel, which if perfected, could offer scientists a new method of probing other important membrane proteins and ion channels that could lead to advancements in the field of cardiovascular medicine. Cardiovascular complications such as stroke and coronary heart disease remain the number one cause of death in all Americans*.

NIBIB Grant for $1.1M to Continue Structural Protein Footprinting Research

To further support his research efforts, Dr. Chance and the Case Western Reserve Center for Proteomics and Bioinformatics received a four-year grant totaling $1.1 million from the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The grant work will be performed in collaboration with Krzysztof Palczewski, PhD, chair of the Department of Pharmacology at Case Western Reserve University, and Dr. Gupta, instructor at the Case Center for Synchrotron Biosciences (CSB) in New York. Dr. Chance is also the director of the CSB, which provides unique facilities to carry out protein footprinting experiments on GPCRs and their complexes.

"Determining the structure of membrane proteins like GPCRs is particularly difficult, while understanding how drugs function to turn them on and off is even harder, but very important to treating major diseases like depression, heart failure, and diabetes," Dr. Chance said of his research. "Our techniques have provided novel insight into addressing these questions and this funding from the NIH will accelerate these studies."

With this funding, Dr. Chance and co-investigators will continue their development of new biotechnology methods to study GPCRs. The aim of their research is as follows:

  • To improve their mass spectrometry based structural imaging technology 1,000-fold in an effort to better understand how GCPRs are activated and signal information to protein receptors
  • To develop a novel
    '/>"/>

Contact: Christina DeAngelis
christina.deangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. OnychoLase Laser Nail Centers Making a Global Impact, By Bringing Western Medicine To The East
2. Busy Southwestern Orthopedic Practice Joins the NeoStem Stem Cell Collection Network
3. WaferGen Announces that University of Texas Southwestern Medical Center Demonstrates Utility of New SmartChip(TM) Nano-Dispenser with WaferGens SmartChip(TM) High-throughput Real-Time PCR System
4. 40 Years on the Leading Edge: Case Western Reserve Universitys Biomedical Engineering Department Commemorates Achievement, Looks to Future
5. Growing Midwestern Clinical Research Organization Selects OmniComm Systems to Provide eClinical Solutions for Phase IV Studies
6. WaferGen Biosystems, ImmuneRegen BioSciences and University of Texas Southwestern Medical Center to Collaborate on Novel Wound Healing Research
7. Cancer Care of Western New York Becomes First Center in Western New York to Treat Cancer with RapidArc(TM) Radiotherapy Technology from Varian Medical Systems
8. LI-COR Blot Washer Automates Western Blot Processing
9. Case Western Reserve University researcher improves LCDs with 3-D nanoimaging process
10. Brain and Hearing Pioneer, Michael Merzenich, Ph.D. to Speak at Case Western Reserve University
11. Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... NEW YORK and SANTA CLARA, ... Health Corp. (NASDAQ: WBMD ), the leading ... a new WebMD/Medscape survey that provide novel ... role in aiding diagnosis and care.  Dr. Eric ... genomics and digital medicine, who serves as both Editor-in-Chief ...
(Date:9/22/2014)... by researchers at the USC Viterbi School of ... 3-D microfluidic system quickly and cheaply by simply ... Microfluidic systems are used in many fields including ... volumes of fluids for use in applications such ... diagnostic testing, and synthetic chemistry. Traditionally, microfluidic devices ...
(Date:9/22/2014)... Analysis of circulating tumor cells (CTCs) in a mouse ... expression in several groups of CTCs, including significant differences ... ability to generate metastases. In their study reported ... , investigators from the Massachusetts General Hospital (MGH) Cancer ... found unexpected factors that may prove to be targets ...
(Date:9/22/2014)... Minnesota electrical engineering researchers have developed a unique ... mechanical transportation of light. The discovery could have ... optical devices for computation and communication. , The ... computer engineering assistant professor Mo Li and his ... and will appear in the October issue of ...
Breaking Biology Technology:WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5Massachusetts General study reveals gene expression patterns in pancreatic CTCs 2Massachusetts General study reveals gene expression patterns in pancreatic CTCs 3Engineers show light can play seesaw at the nanoscale 2
... Massachusetts and LAUSANNE, Switzerland, August 6 /PRNewswire/,-- Curis, ... development company focused on,developing proprietary targeted medicines for ... companies with a focus on the development of,prescription ... that they,have entered into a worldwide, exclusive license ...
... China, Aug. 6 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ... CSKI ), a leading,fully integrated pharmaceutical company producing ... announced the appointment of Mr.,William Wei Lee as an ... effective August 4, 2009. Mr. Jiang Qi-Feng resigned from ...
... 6 Interleukin Genetics, Inc. (NYSE Amex: ... conference call and webcast on Thursday, August 13, 2009, at 4:30 ... financial results. , , To access the live ... replay access of the teleconference will be available on the Investors ...
Cached Biology Technology:Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305 2Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305 3Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305 4Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305 5Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305 6China Sky One Medical, Inc. Appoints New Independent Director 2China Sky One Medical, Inc. Appoints New Independent Director 3
(Date:9/22/2014)... (Sept. 22, 2014) As genetic sequencing technologies continue ... is a critical need to establish appropriate policies and ... experts have said. A special policy issue of the ... online today and edited by experts with the Center ... of Medicine gives policy makers the tools to jumpstart ...
(Date:9/22/2014)... fishes that manufacture their own "antifreeze" proteins to ... an unfortunate side effect, researchers report: The protein-bound ... melting even when temperatures warm. , The ... the National Academy of Sciences . , "We ... of the evolution of antifreeze proteins in Antarctic ...
(Date:9/22/2014)... of the fires captured in this image burn in Khabarovsk ... Okhotsk. Dozens of red hotspots, accompanied by plumes of smoke ... grey, blows to the east towards the Sea of Okhotsk. ... of this area, swampy forest inhabit the central depression, and ... While large wildfires are common in Russia in the summer, ...
Breaking Biology News(10 mins):Experts provide much-needed policy analysis for clinical integration of next generation sequencing 2Experts provide much-needed policy analysis for clinical integration of next generation sequencing 3Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3
... Bread wheat ( Triticum aestivum ) is one of ... the calories consumed by people. Fully 35% of the world,s ... Now an international team of scientists, including a group from ... analysis of its full genome. The study reveals ...
... pro-iBiosphere aims to prepare (= pro), through ... (= sphere) for intelligent (= i) management of biodiversity ... Open Biodiversity Knowledge Management System will play a major ... It will create an authoritative framework including discovery of ...
... published by the U.S. Department of Agriculture,s (USDA) Economic ... the journal Science examine the relationship between ... and their importance in agricultural input industries. The ... study that provides new details on the rapid growth ...
Cached Biology News:Bread wheat's large and complex genome is revealed 2Bread wheat's large and complex genome is revealed 3Toward an European open biodiversity knowledge management system 2USDA study shows trends in public and private agricultural R&D 2
... Blot Processing mini Tray (3 per ... gel staining and blot processing.Automated staining ... for proteins and nucleic acid analysis.Prepares ... and chromogenic detection.Programmable control of protocol, ...
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
... 1 g. High quality kits ... preparation that give consistent and ... and tissues.Clean up samples from ... Accurately quantitate protein for first-dimension ...
... Varian Cary 50 Microplate Reader ... cost per analysis by extending ... the award-winning Cary 50 instruments. ... to 384 samples in microlitre ...
Biology Products: