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Case Western Reserve University-led team takes high resolution photo of a K+ channel
Date:7/13/2010

of this study provide support for a newly proposed gating mechanism of the K+ channel, which if perfected, could offer scientists a new method of probing other important membrane proteins and ion channels that could lead to advancements in the field of cardiovascular medicine. Cardiovascular complications such as stroke and coronary heart disease remain the number one cause of death in all Americans*.

NIBIB Grant for $1.1M to Continue Structural Protein Footprinting Research

To further support his research efforts, Dr. Chance and the Case Western Reserve Center for Proteomics and Bioinformatics received a four-year grant totaling $1.1 million from the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The grant work will be performed in collaboration with Krzysztof Palczewski, PhD, chair of the Department of Pharmacology at Case Western Reserve University, and Dr. Gupta, instructor at the Case Center for Synchrotron Biosciences (CSB) in New York. Dr. Chance is also the director of the CSB, which provides unique facilities to carry out protein footprinting experiments on GPCRs and their complexes.

"Determining the structure of membrane proteins like GPCRs is particularly difficult, while understanding how drugs function to turn them on and off is even harder, but very important to treating major diseases like depression, heart failure, and diabetes," Dr. Chance said of his research. "Our techniques have provided novel insight into addressing these questions and this funding from the NIH will accelerate these studies."

With this funding, Dr. Chance and co-investigators will continue their development of new biotechnology methods to study GPCRs. The aim of their research is as follows:

  • To improve their mass spectrometry based structural imaging technology 1,000-fold in an effort to better understand how GCPRs are activated and signal information to protein receptors
  • To develop a novel
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Contact: Christina DeAngelis
christina.deangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

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