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Case Western Reserve University-led team takes high resolution photo of a K+ channel
Date:7/13/2010

CLEVELAND July 13, 2010 Using chemical labeling and mass spectrometry-based techniques, Mark Chance, PhD, director of the Case Western Reserve University School of Medicine Center for Proteomics and Bioinformatics and professor of physiology and biophysics; Sayan Gupta, PhD, instructor at the Case Center for Proteomics and Bioinformatics; and a research team from the University of Oxford, for the first time, were able to take a high resolution picture of the open state of a K+ channel, allowing them to comparatively analyze gating mechanisms important to heart function and nerve signaling in addition these techniques have already permitted Case Western investigators to gain a deeper understanding of G-protein coupled receptors (GPCRs).

GPCRs, the targets of more than half of all pharmaceutical drugs, are important signaling molecules and help regulate proper channel function. With a new window on the open state of the channel, researchers have an opportunity to better understand the effectiveness of drugs used to treat and prevent cardiovascular diseases.

"The discoveries made by Mark [Chance] and his team have the potential to revolutionize modern medicine as we know it," said Daniel Simon, MD, Chief of Cardiovascular Medicine at University Hospitals Case Medical Center, director of the Case Cardiovascular Center and the Herman K. Hellerstein Professor of Cardiovascular Research at Case Western Reserve School of Medicine. "With an advanced understanding of GPCRs and ion channels comes a better understanding of how modern medicine works, which would theoretically increase pharmaceutical efficiency and enhance the quality of countless cardiovascular-related drugs."

In the study, published in the July edition and featured on the cover of the July issue of Structure, Dr. Chance and his research team discovered the details of the paths by which ions flow through the inwardly-rectifying potassium channel KirBac3.1.The results
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Contact: Christina DeAngelis
christina.deangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

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