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Case Report Suggests Microbiome Therapeutics' NM504 May Improve Tolerability of Metformin While Improving Blood Glucose Control
Date:9/11/2013

sociated with type 2 diabetes.  Modern diets often lack essential ingredients that support a healthy microbiome, so we designed NM504 to replace key missing elements that impact the GI microbiome in ways known to be beneficial to metabolic and gastrointestinal health.  We look forward to completing our pilot trial that is further testing the hypothesis that NM504 may have utility as an adjunctive therapy to metformin."

MBT is developing evidence-based microbiome modulators—therapies designed to alter bacterial populations and their environment in the gastrointestinal (GI) tract to treat and prevent serious health conditions.  MBT's microbiome modulators act on multiple factors in the GI environment, providing specialized ingredients that augment the growth of targeted desirable bacterial strains and discourage the growth of others that may be harmful.  These shifts in the GI microbiome have the potential to have a major impact on factors affecting metabolism and weight, such as the endocrine response that affects appetite, metabolism and energy storage. 

NM504 contains a proprietary combination of plant-derived soluble and insoluble fibers and antioxidants formulated to help prediabetic and diabetic individuals achieve healthy blood glucose levels and manage their body weight.  NM504 is designed to shift the GI microbiome by replacing essential ingredients that are typically missing in the diets of prediabetic and diabetic individuals. This replacement strategy provides an advantage for beneficial members of the gut microbiota, while disadvantaging others that are harmful to metabolic health. The resulting microbiome shift produces an increase in the production of metabolites and signaling molecules that help regulate metabolic hormones, improve GI motility, maintain the protective intestinal mucosal barrier, reduce caloric absorption and reduce appetite. 

NM504 is being studied in two
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SOURCE MicroBiome Therapeutics LLC
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