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Case Report Suggests Microbiome Therapeutics' NM504 May Improve Tolerability of Metformin While Improving Blood Glucose Control
Date:9/11/2013

BROOMFIELD, Colo., Sept. 11, 2013 /PRNewswire/ -- MicroBiome Therapeutics LLC, (MBT), a biotechnology company developing pharmaceutical and medical food products that shift the human microbiome in specific ways for improved health, today reported publication of a case report suggesting a potentially important new application for its lead product, NM504.  NM504 is in clinical development to promote healthy blood glucose levels and metabolic fitness in prediabetic and diabetic populations.

In the case report1, currently available in the online edition of Beneficial Microbes, researchers describe how co-administration of NM504 eliminated the dose-limiting diarrhea caused by metformin in a patient with newly-diagnosed type 2 diabetes.  Metformin, a safe, effective and inexpensive medication favoring weight loss, is the most widely prescribed diabetes drug worldwide, and it is recommended for initial treatment of type 2 diabetes by the American Diabetes Association. However, diarrhea is a well-known side effect of metformin therapy, affecting an estimated 20% of patients.  Physicians report diarrhea as a frequent cause of metformin discontinuation or dosage limitation. The second-line therapies prescribed in these cases as a substitute for metformin are expensive and carry risks of potentially serious side effects.

"NM504 virtually eliminated the diarrhea caused by metformin in this patient with type 2 diabetes and was also associated with additional large decreases in his highly elevated blood glucose levels," commented Mark Heiman, Ph.D., a co-author of the case report and chief scientific officer of MicroBiome Therapeutics.

Dr. Heiman continued, "Research shows that the human GI microbiome plays an important role in the regulation of metabolic processes, including changes as
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SOURCE MicroBiome Therapeutics LLC
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