Navigation Links
Carnegie Mellon's Jeffrey Hollinger Leads Research Team Developing New Tools To Ease Pain of Combat Injuries
Date:8/31/2012

PITTSBURGH, Aug. 31, 2012 /PRNewswire/ -- A multidisciplinary research team led by Carnegie Mellon University is developing new nanostructural polymer-based treatments to eliminate pathological bone formation in soft tissue, a common occurrence following orthopedic surgeries and amputations.  

(Logo: http://photos.prnewswire.com/prnh/20020422/CMULOGO )

"Our tactic is to develop a solution that will control the pathological growth of bone in muscle and tendons (called heterotopic ossification) that frequently occurs following bone trauma and orthopedic surgery," said Jeffrey O. Hollinger, professor of biomedical engineering and biological sciences, and head of CMU's Bone Tissue Engineering Center.

"When bone is severely injured and amputation of a limb is necessary, or as a consequence of major orthopedic procedures, unwanted new bone formation occurs in the soft tissues surrounding the operated bone and appears as pieces of gravel-like bone. Consequently, there is pain and discomfort at an amputation stump where a prosthesis is secured. We are developing a therapy that will eliminate heterotopic ossification," he added.

Data suggests heterotopic ossification occurs in more than 60 percent of military personnel who incur bone injury resulting in limb amputation. Therefore, the CMU labs of J.C. Warner University Professor of Natural Sciences and Chemistry Professor Krzysztof Matyjaszewski are using a three-year, $2.93 million grant from the Department of Defense to work with researchers at the United States Military Academy at West Point, the University of Michigan and the Naval Medical Center in Portsmouth, Va., to produce a therapeutic solution to eliminate heterotopic ossification.   

Hollinger, the principal investigator for the grant, said the patient-centric focus of the team's research includes a nanostructural polymer composite developed by Matyjaszewski to deliver unique RNA identified in the Hollinger lab, into cells at the bone trauma site to prevent heterotopic ossification in the soft tissue.

"The problem of heterotopic ossification is more widespread than the military population," Hollinger said. More than 90 percent of hip replacement operations in the civilian U.S. population also show signs of heterotopic ossification. Because the problem is so complex, CMU researchers report that it will take a team of clinicians and researchers to develop solutions.

"We see this collaborative research as a win for both military and civilian populations. And we see this particular research project as a great way to help us change our research paradigm at West Point," said J. Kenneth Wickiser, director of the Center for Molecular Science in the Department of Chemistry & Life Science at the United State Military Academy. "Our cadets are gaining invaluable hands-on research experience as summer interns at CMU's biomedical engineering labs. And we are becoming more competitive in our abilities at West Point to tackle more innovative research initiatives," Wickiser said.

Ashley Phillips, a sophomore West Point cadet, praised the CMU internship program for its concise and rigorous approach to problem solving. "I want to be a doctor and this CMU research experience gives me an excellent platform for growth and a medium for sharing my work with other cadets," said Phillips of Mukwonago, Wis.

CMU researchers report there is a patent pending on the therapy and a clinical trial schedule will be developed once the preventative platform is fully lab tested.                 

About Carnegie Mellon University: Carnegie Mellon (www.cmu.edu) is a private, internationally ranked research university with programs in areas ranging from science, technology and business, to public policy, the humanities and the arts. More than 11,000 students in the university's seven schools and colleges benefit from a small student-to-faculty ratio and an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration and innovation. A global university, Carnegie Mellon's main campus in the United States is in Pittsburgh, Pa. It has campuses in California's Silicon Valley and Qatar, and programs in Africa, Asia, Australia, Europe and Mexico. The university is in the midst of "Inspire Innovation: The Campaign for Carnegie Mellon University," which aims to build its endowment, support faculty, students and innovative research, and enhance the physical campus with equipment and facility improvements.


'/>"/>
SOURCE Carnegie Mellon University
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin
2. Synthetic Biologics Appoints Jeffrey J. Kraws as Independent Chairman
3. A Genetic Approach For Crohns And Colitis Disease Is Financed By The Jeffrey Epstein VI Foundation
4. Research at Rice University leads to nanotube-based device for communication, security, sensing
5. Discovered Evolution of Genomic Sequences -- from Ocean Archaea to Brain Cancer -- Leads to New Synthetic Replikin Vaccines for Infectious Diseases and Cancer
6. ScaleMatrix Leads the Way Unveiling the Industry’s First Transparent Pricing Tool in Private Cloud Offerings
7. Breakthrough by U of T-led research team leads to record efficiency for next-generation solar cells
8. Wolters Kluwer Research Now Available via Bloomberg Tradebook
9. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
10. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
11. Researching graphene nanoelectronics for a post-silicon world
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... Irvine, Calif. (PRWEB) , ... July 20, 2017 ... ... James G. Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering ... Beckman-Argyros Vision Research Award winner. Presented annually, the award recognizes an individual ...
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a leader ... artificial intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee Meeting ... , Baras, Associate Director of Pathology Informatics, will present “The Digital Pathology ...
(Date:7/18/2017)... New Jersey (PRWEB) , ... July 18, 2017 , ... ... that aligns with your needs and has the capabilities to properly execute your job ... site customglassparts.com is a sourcing portal designed to showcase the company’s ...
(Date:7/18/2017)... ... 18, 2017 , ... Recently recognized by CIO Magazine as ... migration of its flagship cloud-based product Planet Life Cycle – a robust work ... system that merges strategic and financial planning with execution. The solution is leveraged ...
Breaking Biology Technology:
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
Breaking Biology News(10 mins):