Navigation Links
Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin
Date:1/19/2012

toxicologist at the University of California, Santa Cruz, who was studying manganese toxicity, noticed that GPP130 was sensitive to manganese. He called Linstedt who began to do a series of experiments on how manganese affects GPP130. Around this time Mukhopadhyay joined Linstedt's lab for his post-doctoral training. He quickly discovered that as concentrations of manganese rise inside the cell, GPP130 changes its pathway and goes directly to the lysosome where it is degraded.

Because Shiga toxin was dependent on GPP130 and manganese caused loss of GPP130, Linstedt and Mukhopadhyay decided to see whether manganese would protect against Shiga toxin infection. In cell cultures, manganese treatment yielded an almost 4,000-fold increase in the amount of Shiga toxin required to induce cell death. In a mouse model, mice exposed to a high dose of Shiga toxin and treated with non-toxic doses of manganese were 100 percent resistant to the toxin.

By introducing manganese, Linstedt and Mukhopadhyay were able to remove Shiga toxin's vehicle for avoiding degradation GPP130. The researchers feel that this could be a promising treatment for neutralizing the effects of Shiga toxin in humans.

"Manganese is inexpensive. While Shiga toxin infection affects people in the developed world, it affects far more people in the developing world. An inexpensive, accessible treatment not a designer drug is the ideal solution," Linstedt said. "We know the toxicity levels of manganese in humans; we know ways to administer it. While further testing is needed to determine if manganese is a suitable treatment for humans, I'm optimistic that trials should move forward quickly."

The researchers also believe that manganese might be able to be used in conjunction with antibiotics. Currently, if an infected person is given an antibiotic, the antibiotic kills the bacteria (E. coli or Shigella) that produce the toxin. This releases the toxin in larger amounts and cau
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Carnegie Mellon researchers electrify polymerization
2. Carnegie Mellon scientists create rainbow of fluorescent probes
3. 2010 Carnegie Science Awardees Announced
4. Carnegie Mellon MRI technology that noninvasively locates, quantifies specific cells in the body
5. Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
6. Start of Phase IIa Study in Acute Lung Injury Patients Marks Development Milestone
7. Amgen Presents Final Results from the Largest Phase 3 Open-Label Study Assessing the Safety and Efficacy of Nplate® (Romiplostim)
8. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
9. Study finds chronic abnormal brain blood flow in Gulf War veterans
10. Causes of Gulf War Illness are complex and vary by deployment area -- Baylor University study
11. Metabolex Announces Positive Results From its Clinical Study of Arhalofenate in Combination With Febuxostat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin
(Date:7/11/2014)... -- Research and Markets  has announced the addition ... Industry Analysis, Size, Share, Growth, Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is a ... RNA) into cells. This technology helps the cells to ... metabolism by affecting the nuclear genes. The transfection technology ...
(Date:7/11/2014)... July 11, 2014 Cayenne Medical, ... specializing in the soft tissue reconstruction segment, announced ... System for surgeries involving the shoulder and extremities. ... a novel, inserter-controlled deployment method. The unique delivery ... deployment, anchor pull-out, or anchor displacement (also commonly ...
(Date:7/10/2014)... Boston, Mass. (PRWEB) July 10, 2014 ... , today announced that Alan Swahn, a former vice ... Terascala’s executive team as vice president of marketing. Terascala’s ... from Dell and NetApp create the highest performance and ... has been appointed to guide Terascala’s channel expansion and ...
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... saliva can be used to quickly and effectively screen for ... children, says research in the June 2 issue of the ... at the University of Alabama at Birmingham (UAB) found saliva ... samples were used, and 97.4 percent of babies when the ...
... curtain about to rise on a much-anticipated new era of ... for food, fuel, and other uses scientists are reporting a ... corn, tomatoes, rice and other food crops. Their article appears ... Jorge Gardea-Torresdey and colleagues at The University of Texas ...
... 2011 VWR International, LLC, a global leader ... that it acquired the business of BioExpress Corp. ... in 1985, BioExpress is a well-respected distributor in ... offers over 200 well-known, multi-national brands, including its ...
Cached Biology Technology:Saliva is effective in screening for CMV infection in newborns, says NIH-funded research 2Saliva is effective in screening for CMV infection in newborns, says NIH-funded research 3VWR International, LLC Acquires BioExpress Corp. 2
(Date:7/11/2014)... 2014 Researchers have pioneered a revolutionary new ... technology, called Virtual Finger, allows scientists to move ... and synapses using the flat surface of their ... imaging studies orders of magnitude more efficient, saving ... across many areas of experimental biology. The software ...
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
(Date:7/10/2014)... 27, 2014  The American Academy of Forensic ... Standards and Technology (NIST) and the Department of ... and forensic science expert members to the Forensic ... element of the NIST,s Organization of Scientific Area ... first appointments made to the new FSSB that ...
Breaking Biology News(10 mins):Virtual finger enables scientists to navigate and analyze complex 3D images 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... that the first antibiotics were discovered almost a century ... are still serious diseases for humans in the twenty-first ... are more than 8 million new cases of tuberculosis ... than 300,000 of these are due to multidrug-resistant strains ...
... Illinois anthropology professor Ripan Malhi looks to ... to the Americas and what happened to them once they were ... meeting, " Ancient DNA: The First Three Decades ," at The ... an affiliate of the Institute for Genomic Biology at Illinois ...
... a gene associated with a high risk of severe ... actual cause of this form of asthma, a leading ... is a complex disease, with multiple interacting causes, we ... ages two and six," said co-lead author of the ...
Cached Biology News:Bacteria use lethal cytotoxins to evade antibiotic treatment 2Ancient, modern DNA tell story of first humans in the Americas 2Novel gene variant found in severe childhood asthma 2
Request Info...
Human Osteocalcin (1-22) mature form. Also reacts with Osteocalcin (1-44) and Osteocalcin (1-49). No reactivity with Bone sialoprotein....
TGF-beta 1,-2,-3 MAb (Clone 1D11)...
1/4" to 1/8" Adapter for Reflectance Probe Holder...
Biology Products: