Navigation Links
Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin
Date:1/19/2012

toxicologist at the University of California, Santa Cruz, who was studying manganese toxicity, noticed that GPP130 was sensitive to manganese. He called Linstedt who began to do a series of experiments on how manganese affects GPP130. Around this time Mukhopadhyay joined Linstedt's lab for his post-doctoral training. He quickly discovered that as concentrations of manganese rise inside the cell, GPP130 changes its pathway and goes directly to the lysosome where it is degraded.

Because Shiga toxin was dependent on GPP130 and manganese caused loss of GPP130, Linstedt and Mukhopadhyay decided to see whether manganese would protect against Shiga toxin infection. In cell cultures, manganese treatment yielded an almost 4,000-fold increase in the amount of Shiga toxin required to induce cell death. In a mouse model, mice exposed to a high dose of Shiga toxin and treated with non-toxic doses of manganese were 100 percent resistant to the toxin.

By introducing manganese, Linstedt and Mukhopadhyay were able to remove Shiga toxin's vehicle for avoiding degradation GPP130. The researchers feel that this could be a promising treatment for neutralizing the effects of Shiga toxin in humans.

"Manganese is inexpensive. While Shiga toxin infection affects people in the developed world, it affects far more people in the developing world. An inexpensive, accessible treatment not a designer drug is the ideal solution," Linstedt said. "We know the toxicity levels of manganese in humans; we know ways to administer it. While further testing is needed to determine if manganese is a suitable treatment for humans, I'm optimistic that trials should move forward quickly."

The researchers also believe that manganese might be able to be used in conjunction with antibiotics. Currently, if an infected person is given an antibiotic, the antibiotic kills the bacteria (E. coli or Shigella) that produce the toxin. This releases the toxin in larger amounts and cau
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Carnegie Mellon researchers electrify polymerization
2. Carnegie Mellon scientists create rainbow of fluorescent probes
3. 2010 Carnegie Science Awardees Announced
4. Carnegie Mellon MRI technology that noninvasively locates, quantifies specific cells in the body
5. Spherix Announces Successful Completion of Important Toxicology Study of SPX-106
6. Start of Phase IIa Study in Acute Lung Injury Patients Marks Development Milestone
7. Amgen Presents Final Results from the Largest Phase 3 Open-Label Study Assessing the Safety and Efficacy of Nplate® (Romiplostim)
8. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
9. Study finds chronic abnormal brain blood flow in Gulf War veterans
10. Causes of Gulf War Illness are complex and vary by deployment area -- Baylor University study
11. Metabolex Announces Positive Results From its Clinical Study of Arhalofenate in Combination With Febuxostat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin
(Date:8/30/2014)... August 31, 2014 The Global ... professional and in-depth study on the current state ... and China. , The report provides a basic ... industry chain structure. Global market analysis and Chinese ... on history, developments, trends and competitive landscape of ...
(Date:8/29/2014)... DIEGO, Aug. 29, 2014  Pfenex Inc. (NYSE ... the development of high-value and difficult to manufacture ... update and reported financial results for the second ... the successful completion of our initial public offering, ... our biosimilar product candidates, derived from our proprietary ...
(Date:8/29/2014)... of the most promising technologies for future quantum circuits ... instead of electrons. First, it is necessary to be ... control their direction. Researchers around the world have made ... now scientists at the Niels Bohr Institute have succeeded ... at a time and in a particular direction. The ...
(Date:8/29/2014)... The global companion diagnostics market ... It is expected to grow at a CAGR ... valued at $1.8 billion in 2013, according to ... , For more information regarding analysis details and ... research report, titled “Companion Diagnostics Market (Breast Cancer, ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... VANCOUVER, Sept. 17 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. ... today that it reached a favourable,agreement with ... settle all outstanding patent litigation with respect ... agreement now in place, Angiotech expects that ...
... Sept. 17 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ... the,Company,s President, will present an overview of the ... 37th Annual Investment Conference,in San Francisco. Dr. Henderson,s ... 8:30 am PT. Dr. Henderson,s presentation will ...
... BioMed Realty Trust, Inc.,(NYSE: BMR ) today ... quarter 2007 dividend of $0.31 per share of common ... $1.24 per common share. BioMed also announced that ... per share of the company,s 7.375% Series A Cumulative,Redeemable ...
Cached Biology Technology:Angiotech reaches agreement with Johnson & Johnson to settle outstanding patent litigation 2Angiotech reaches agreement with Johnson & Johnson to settle outstanding patent litigation 3Angiotech reaches agreement with Johnson & Johnson to settle outstanding patent litigation 4Keryx Biopharmaceuticals to Present at Bank of America Investment Conference 2BioMed Realty Trust Declares Third Quarter 2007 Common Stock and Preferred Stock Dividends 2
(Date:8/29/2014)... Davis have made some surprising discoveries about the ... immunodeficiency virus (SIV), the team found that specialized ... early responders to viral invasion and are the ... called interleukin-1 beta (IL-1β). , Though aimed ... of the gut epithelium that provides a barrier ...
(Date:8/29/2014)... Scientists at the Barshop Institute for Longevity and ... the UT Health Science Center at San Antonio, have ... the longest-lived rodent, the naked mole rat. , ... naked mole rats protects and alters the activity of ... proteins. , The factor also protects proteasome function in ...
(Date:8/29/2014)... recently, little has been known about what genetic changes ... of scientists, one of whom is a University of ... that genes controlling the development of the brain and ... The study was published Aug. 28 in Science ... is online at http://www.sciencemag.org/ ., The domestication of ...
Breaking Biology News(10 mins):The early cost of HIV 2Factor in naked mole rat's cells enhances protein integrity 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
... BMC Microbiology highlights some of the recent ... the genes involved in the complex interplay between microbes ... members of the international Plant-Associated Microbe Gene Ontology (PAMGO) ... include a language that gives researchers a shared vocabulary ...
... You may recall as a child catching the itchy red ... varicella zoster virus and was responsible for nearly 4 million ... (CDC), until a vaccine introduced in 1995 reduced that number ... suffered from chicken pox, the varicella zoster virus may still ...
... is trying to coax human stem cells to turn ... be used to replace damaged tissue in people with ... an assistant professor of chemical and molecular engineering in ... $150,000 two-year grant from the March of Dimes Foundation ...
Cached Biology News:Special issue of BMC Microbiology spotlights standardized language for describing microbes 2Special issue of BMC Microbiology spotlights standardized language for describing microbes 3Childhood chicken pox could affect oral health years later 2Researcher seeks to turn stem cells into blood vessels 2Researcher seeks to turn stem cells into blood vessels 3
Rabbit polyclonal to DcR2 ( Abpromise for all tested applications). entrezGeneID: 8793 SwissProtID: Q9UBN6...
...
...
Mouse Amphiregulin MAb (Clone 206220)...
Biology Products: