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Caris Life Sciences nimmt Next-Generation Sequencing zur Verbesserung des evidenzbasierten Tumorprofilierungsservices für Krebspatienten auf
Date:1/28/2013

ausschließlich auf eine einzige Technologieplattform verlassen. Zum Beispiel würde die NGS-Analyse alleine den Onkologen keine wichtigen Einblicke in einige der am häufigsten verwendeten, begleitdiagnostischen Verfahren bieten, da die von der FDA zugelassene Kennzeichnung den Einsatz von spezifischen und unterschiedlichen Profilierungstechnologien verlangt."

NGS steht hinter den vom Unternehmen in den Select und Comprehensive Profilen durchgeführten Mutationsanalysen, die eine schnelle Prüfung und breitere Erfassung von somatischen Mutationen in Hunderten von Hotspots im Krebsgenom erlauben. Darüber hinaus ermöglicht diese kritische Technologie die Aufnahme von neuen Biomarkern, die potenzielle klinische oder Forschungsanwendungen haben könnten. Die Einbeziehung dieser neuen Biomarker steigert den Nutzwert des Caris Registry® weiter, in dem kritische Daten über Biomarker, Medikamente und Behandlungsergebnisse erfasst werden, die ein besseres Verständnis von der Behandlung verschiedener Krebsarten ermöglichen.

„Sowohl aus Sicht der Bandbreite von Informationen als auch des Nutzwertes der Forschungsergebnisse ist NGS am wertvollsten, wenn es mit anderen Technologien wie IHC und FISH kombiniert wird, um eine umfassendere Beurteilung des Tumors eines Patienten zu ermöglichen", erklärt Sandeep Reddy, MD, Clinical Professor of Medicine an der David Geffen School of Medicine der University of California, Los Angeles (UCLA) und Senior Medical Director von Caris Life Sciences. „Die Sequenzierung alleine kann möglicherweise relevante Erg
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