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Caris Life Sciences Symposium to Explore Advances in Next Generation Sequencing for Gynecologic Cancers
Date:3/8/2013

sights about the genomics of the disease."

The application of NGS technologies holds significant promise in the treatment of ovarian cancer, the most lethal gynecologic cancer in the U.S., resulting in approximately 14,000 deaths annually.1 Although primary ovarian carcinomas initially respond to platinum-based therapy, this response is often incomplete, resulting in relapse in almost 80% of women with advanced disease.2‐4 It's therefore critical to thoroughly assess the entire biology of a tumor using NGS technology, along with more traditional profiling technologies like IHC and FISH.

"Given the high recurrence rate and poor long‐term survival of women with advanced ovarian cancer, there is an urgent need for improved methods of biomarker target identification, chemotherapy selection and clinical trials enrollment," explained Dr. Coleman. "Ovarian neoplasms differ widely with respect to their clinical behavior and response to chemotherapy, suggesting that each patient's disease may harbor unique, clinically actionable molecular targets. When paired with traditional gold-standard pathology, NGS information has the promise to lead to superior therapeutic associations, more rapid and efficient identification of candidates for new clinical trials, and ultimately, better patient management."

In addition to Dr. Coleman, the symposium faculty includes the below experts, whose presentations will address the following topics:

  • NGS Targets in Ovarian Carcinoma: Ryan Bender , Ph.D, FACMG, Director, Molecular Genetics, Caris Life Sciences
  • Integrating NGS Data Into Patient Care – Today: Deborah Zajchowski , Ph.D, Clearity Foundation
  • The Future of Tumor Profiling in Gynecologic Cancers: Maurie Markman , M.D., SVP & National Director of Medical Oncology
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