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Caris Life Sciences Presents Key Biomarker Data at 2013 Association for Molecular Pathology (AMP) Annual Meeting
Date:11/14/2013

IRVING, Texas, Nov. 14, 2013 /PRNewswire/ -- Caris Life Sciences®, a leading biosciences company focused on fulfilling the promise of personalized medicine, will present five tumor profiling studies at the 2013 Annual Meeting of the Association for Molecular Pathology (AMP), held this week in Phoenix, Ariz. Results were obtained using Caris' comprehensive tumor profiling service, Molecular Intelligence™. Presentation highlights include:

  • Comprehensive data on ERBB2 (HER2) mutation, gene copy number and protein expression highlight the role of ERBB2 alteration as a proliferative driver in some breast cancer, ovarian cancer, colorectal cancer, bladder cancer and non-small-cell lung carcinoma (NSCLC) patients.
  • Presentation on the role of cMET activation and overexpression in several cancer types and the importance of multi-technology analysis in determination of the oncogene status.
  • A study demonstrating the power of combining DNA sequencing technology with immunohistochemistry (IHC) to assess PTEN expression levels in cancer patients.

In the study, "ERBB2 (HER2) Mutational Spectrum in Solid Tumors," Caris analyzed the ERBB2 gene in nearly 7,500 breast, colorectal, lung, uterine/cervical, ovarian, bladder and pancreatic cancer patients.  By utilizing a variety of profiling technologies, including Next-Generation Sequencing (NGS), IHC and dual in situ hybridization (dual ISH), Caris found that ERBB2 may be the sole identified driver mutation in the various tumor types listed above. The study also confirmed that amplification of ERBB2 is a key driver in HER2 overexpression, and that amplification and mutation in ERBB2 coexist in some cancer patients. Of particular interest to treating oncologists and affected patients, the study establishes the need for further research on the effectiveness of targeted anti-HER
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