IRVING, Texas, Nov. 14, 2013 /PRNewswire/ -- Caris Life Sciences®, a leading biosciences company focused on fulfilling the promise of personalized medicine, will present five tumor profiling studies at the 2013 Annual Meeting of the Association for Molecular Pathology (AMP), held this week in Phoenix, Ariz. Results were obtained using Caris' comprehensive tumor profiling service, Molecular Intelligence™. Presentation highlights include:
In the study, "ERBB2 (HER2) Mutational Spectrum in Solid Tumors," Caris analyzed the ERBB2 gene in nearly 7,500 breast, colorectal, lung, uterine/cervical, ovarian, bladder and pancreatic cancer patients. By utilizing a variety of profiling technologies, including Next-Generation Sequencing (NGS), IHC and dual in situ hybridization (dual ISH), Caris found that ERBB2 may be the sole identified driver mutation in the various tumor types listed above. The study also confirmed that amplification of ERBB2 is a key driver in HER2 overexpression, and that amplification and mutation in ERBB2 coexist in some cancer patients. Of particular interest to treating oncologists and affected patients, the study establishes the need for further research on the effectiveness of targeted anti-HER2 therapies for patients with non-amplified ERBB2 mutated cancers.
Two additional data presentations by Caris at this year's annual meeting further demonstrate that a multi-technology approach to tumor profiling offers the most comprehensive, actionable treatment information. In both a 9,000-plus patient study on the importance and role of cMET gene expression and a 1,600-plus patient study on how to best assess PTEN protein expression levels, the use of traditional laboratory methodologies, such as IHC and fluorescence in situ hybridization (FISH), in combination with sequencing technologies like NGS, was critical to rendering a complete and accurate view of a tumor's biology.
"Our data presentations at this year's Annual Meeting clearly validate the use of a multi-platform approach when profiling a patient's tumor," said Zoran Gatalica, M.D., DSc, Executive Medical Director at Caris Life Sciences. "For the treating physician, this means Caris Molecular Intelligence provides the most useful information available when selecting therapy for critically ill cancer patients."
A full listing of the company's data presentations include:
About Caris Life Sciences
Caris Life Sciences is a leading biosciences company focused on fulfilling the promise of personalized medicine. As the first commercial mover in comprehensive molecular profiling in oncology, Caris Molecular Intelligence™ is an industry vanguard, with 50,000-plus patients profiled and counting. Ordered by nearly 6,000 oncologists in 58 countries, Molecular Intelligence correlates molecular data generated from a patient's tumor with biomarker/drug associations derived from clinical cancer literature. Using a variety of advanced and clinically-relevant technologies, Caris provides oncologists with the most clinically actionable information to help them personalize treatment for cancer patients. This multi-technology approach enables Caris to identify 43 FDA-approved therapies, compared to the 12 therapies that can be found through use of next-generation sequencing alone. The company is also developing a series of blood tests based on its proprietary Carisome® platform — a revolutionary blood-based testing technology for diagnosis, prognosis, and theranosis of cancer and other complex diseases. Headquartered in Dallas, Texas, Caris Life Sciences offers services throughout the U.S., Europe, Australia and other international markets. To learn more, please visit www.carislifesciences.com.
|SOURCE Caris Life Sciences|
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