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Caris Life Sciences Enhances Molecular Profiling Service with Addition of ROS1 and MGMT-Methylation Biomarkers
Date:11/12/2012

IRVING, Texas, Nov. 12, 2012 /PRNewswire/ -- Caris Life Sciences™, a leading biosciences company focused on enabling personalized healthcare through molecular profiling and blood-based diagnostic services, has added ROS1 and MGMT-Methylation to the company's evidence-based molecular profiling service. The company is one of only a few entities that offer both of these tests commercially. These markers are believed to serve as clinically-important aids in the development of treatment plans for patients with non-small cell lung cancer (NSCLC) and glioblastoma. 

Using fluorescence in situ hybridization (FISH) technology, Caris' tumor profiling service detects clinically-relevant rearrangements of the ROS1 gene, which are predominantly found in young, non-smoking lung cancer patients.  Patients with theses ROS1 rearrangements have shown increased positive responses to crizotinib, an oral ALK inhibitor. Caris has also added MGMT-methylation (MGMT-ME) gene testing for glioblastoma patients, using pyrosequencing to detect methylation levels. Pyrosequencing was shown to be the best predictor of overall survival and progression-free survival in glioblastoma patients¹. MGMT-ME status is believed to be a useful predictor of glioblastoma patient response to temozolomide, as well as offer helpful prognostic insights.

"The additions of these genes to our molecular profiling service further aid oncologists in determining the appropriate therapeutic regimen for their NSCLC and glioblastoma patients," said Sandeep Reddy, M.D., Clinical Professor of Medicine at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and Senior Medical Director at Caris Life Sciences. "This demonstrates the dynamic, continually evolving nature of the service, which offers physicians the most clinically-relevant biomarker information available today." 

With more than 40,000 patients profi
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