Navigation Links
Cardium's Corgentin Preclinical Program Shows High Levels of Targeting to Acutely Ischemic Heart Muscle Following Intracoronary Infusion
Date:3/11/2008

rms of heart disease."

About Corgentin

Cardium's Corgentin (Ad5IGF-I) preclinical product candidate is a next-generation DNA-based therapeutic using the insulin-like growth factor-I gene carried by an adenovector that is being developed as a potential one-time treatment to promote the preservation and restoration of heart tissue and cardiac function following a heart attack (acute myocardial infarction). Cardium believes that Corgentin, which effectively enables prolonged IGF-I expression within the heart muscle, offers the potential to prevent further damage to heart muscle and improve cardiac healing following a heart attack. The inherent biological properties of IGF-I, which include inhibition of cardiomyocyte apoptosis, adaptive cardiomyocyte hypertrophy, recruitment of cardiac progenitor cells, as well as the induction of angiogenesis and enhancement of cardiac function, combined with Cardium's delivery approach to yield sustained localized expression, provide the rationale for the development of a therapy directed at myocardial repair and restoration. This combination of positive biological attributes and effective delivery supports the potential of Corgentin to improve functional recovery and prevent ventricular dysfunction and the associated progression to congestive heart failure following myocardial infarction and reperfusion.

According to the American Heart Association, the estimated annual incidence of myocardial infarction (MI) is 600,000 new attacks and 320,000 recurrent attacks. Even with the best of care and successful early intervention, such as tissue plasminogen activator (tPA) or emergency angioplasty, about 30% of heart attack patients will eventually go on to develop decompensation through ventricular remodeling and progressive congestive heart failure. This explains in large part why heart failure remains an epidemic health problem despite improved treatments for acute cardiac events.

The safety of systemic IGF-I pr
'/>"/>

SOURCE Cardium Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Genmab Announces Encouraging Preclinical Data for ofatumumab
2. Arius Features Preclinical Data on Antibody Candidates at Two Conferences
3. Preclinical Research on Coronary Stent with CeloNova BioSciences Polyzene(R)- F Nanocoating Receives Award at CIRSE 2007
4. Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
5. Arpida Presents Preclinical and Clinical Data on Iclaprim at ICAAC
6. Arpida Presents Preclinical Data on AR-2474 at ICAAC
7. ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference
8. Genta Announces Presentation of New Clinical and Preclinical Data on Genasense(R) at AACR-NCI-EORTC Targets Conference
9. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
10. Preclinical Efficacy Data Demonstrate Ability of Tengions Neo-Bladder Augment to Restore Bladder Function
11. GelVac(TM) Nasal Powder H5N1 (Bird Flu) Influenza Vaccine Passes Preclinical Toxicology Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Researchers from the National Institute of Standards and ... have demonstrated a new design for an atomic ... comb, or a microcomb. , The microcomb clock, ... of the new journal Optica ,* is ... microcomb, and its accurate conversion of optical frequencies ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer and distributor ... other markets, announced today that it has closed on ... investors led by Novit L.P., an investment arm of ... the signing of a Securities Purchase Agreement under which ... a price per share of $1.00, resulting in a ...
(Date:7/22/2014)... 22, 2014 OHAUS Corporation, a ... mechanical balances and scales, proudly announces its Explorer ... Laboratory Equipment magazine’s 2014 “Readers' Choice” Award for ... year the Explorer was voted the best laboratory ... Choice Awards celebrates “excellence in product design and ...
(Date:7/22/2014)... SHENZHEN, China , July 22, 2014 ... Tech), a subsidiary of BGI, the world,s largest ... a new human whole exome sequencing service based ... service includes in-depth bioinformatics analysis and SNP validation, ... 31, 2014. Complete Genomics, highly ...
Breaking Biology Technology:'Comb on a chip' powers new NIST/Caltech atomic clock design 2CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 2BGI Tech Launches Human Whole Exome Sequencing Service on Complete Genomics' Advanced Platform 3
... the Albert Einstein College of Medicine of Yeshiva University ... can cure hemophilia A (the most common form of ... online February 14 in the Journal of Clinical Investigation. ... is characterized by recurrent, spontaneous bleeding that can cause ...
... at the University of Illinois helped lead a ... strategy for serious Staphylococcus aureus (Staph) infections. The ... version of Science magazine, comes at a time ... for methicillin-resistant S. aureus) are spreading in epidemic ...
... Hospital(R), the premier pediatric research and treatment center, can ... ... More than 60,000 callers,generated $6.1 million dollars during the ... a division of Univision,Communications Inc. The radiothon, benefiting St. Jude ...
Cached Biology Technology:Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report 2New approach may render disease-causing staph harmless 2New approach may render disease-causing staph harmless 3More than $6 Million Raised During Two-Day Event to Support Research and Treatment for Childhood Cancer and Other Catastrophic Diseases 2More than $6 Million Raised During Two-Day Event to Support Research and Treatment for Childhood Cancer and Other Catastrophic Diseases 3
(Date:7/22/2014)... in modifying properties of nanomaterials for application in devices ... recent innovative studies conducted by scientists from the National ... a simple, efficient and low cost technique involving a ... Professor Sow Chorng Haur from the Department of Physics ... properties of two different types of materials can be ...
(Date:7/22/2014)... NY -- As part of a multinational, collaborative effort, ... Sinai have helped identify over 100 locations in the ... in the largest genomic study published on any psychiatric ... published online in Nature , point to biological ... lead to new approaches to treating the disorder, which ...
(Date:7/22/2014)... habitats and trees and not just asphalt and recreation ... University of Colorado Boulder study. , Working on class ... benefits for youth, according to a paper published in ... is one of the first of its kind to ... settings and stress. , "Many schools already offer stress ...
Breaking Biology News(10 mins):NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3Mount Sinai scientists and international team shed new light on schizophrenia 2Mount Sinai scientists and international team shed new light on schizophrenia 3Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3
... will host its largest ever annual meeting next week ... diagnostic professionals plus 1,300 representatives from more than 180 ... sessions and 350 poster presentations, the AMP 2013 Annual ... all things molecular. The event, to be held November ...
... membrane-crossing pores, using Lego-like DNA building blocks, has been developed ... University of Cambridge and the University of Southampton. ... synthetic biology and the technique has potential applications in diagnostic ... current issue of the journal Angewandte Chemie . ...
... Mass. (November 4, 2013) Whitehead Institute scientists report ... known as Birt-Hogg-Dub cancer syndrome also prevents activation of ... This is an unexpected finding, as ... their unchecked growth and expansion. In the case of ...
Cached Biology News:The Association for Molecular Pathology announces highlights of Phoenix meeting 2Designer piercings: New membrane pores with DNA nanotechnology 2Designer piercings: New membrane pores with DNA nanotechnology 3Gene responsible for hereditary cancer syndrome found to disrupt critical growth-regulating pathway 2
HiTrap Streptavidin HP, 5 x 1 ml. Category: Chromatography Systems & Accessories, Systems....
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry....
...
PGD2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry....
Biology Products: