Navigation Links
Cardium's Corgentin Preclinical Program Shows High Levels of Targeting to Acutely Ischemic Heart Muscle Following Intracoronary Infusion
Date:3/11/2008

ion of insulin-like growth factor-I (IGF-I) following a single intracoronary administration in an acute care setting after percutaneous coronary intervention to restore blood flow in heart attack patients. Numerous studies have shown that ongoing damage to cells within the infarct zone continues to occur even after blood flow has been restored, a phenomenon known as reperfusion injury. Corgentin is intended to enhance myocardial healing in and around the infarct zone when used as an adjunct to existing pharmacologic and interventional therapies. Results of the study indicate that non-surgical intracoronary infusion of an adenovector carrying a reporter gene to the heart enables robust protein expression in the area of the myocardium at risk due to ischemia and reperfusion injury. The recently completed preclinical development study follows an earlier pilot study using a similar myocardial infarct model in which intracoronary administration of Ad5IGF-I was found to preserve heart tissue and function following an acute myocardial infarction.

"These positive preclinical results confirm that our intracoronary infusion approach can be used to successfully deliver therapeutic adenovectors into acutely ischemic myocardium such as occurs after a heart attack, at very high efficiency, without the need for any needle injections into the myocardium. Confirmation that non-surgical adenovector delivery through a standard catheter such as those used routinely for angiography can effectively target the acutely diseased heart substantially advances our Corgentin development program," stated Christopher J. Reinhard, Chairman and CEO of Cardium. "The highly effective delivery to acutely ischemic myocardium following intracoronary infusion extends the findings of high first pass uptake of Generx in the hearts of patients with chronic ischemia as observed in the AGENT-1 clinical study, and underscores the potential of these approaches to be applied to the treatment of various fo
'/>"/>

SOURCE Cardium Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Genmab Announces Encouraging Preclinical Data for ofatumumab
2. Arius Features Preclinical Data on Antibody Candidates at Two Conferences
3. Preclinical Research on Coronary Stent with CeloNova BioSciences Polyzene(R)- F Nanocoating Receives Award at CIRSE 2007
4. Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
5. Arpida Presents Preclinical and Clinical Data on Iclaprim at ICAAC
6. Arpida Presents Preclinical Data on AR-2474 at ICAAC
7. ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference
8. Genta Announces Presentation of New Clinical and Preclinical Data on Genasense(R) at AACR-NCI-EORTC Targets Conference
9. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
10. Preclinical Efficacy Data Demonstrate Ability of Tengions Neo-Bladder Augment to Restore Bladder Function
11. GelVac(TM) Nasal Powder H5N1 (Bird Flu) Influenza Vaccine Passes Preclinical Toxicology Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... Jan. 14, 2014 As pet owners drew up their lists ... them wrote: "Take better care of my furry companion." Nowadays there ... and top-brand carrying cases to take the little canine or feline ... feel compelled to buy some pricey toys at the pet store. ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... Limited-English Interpretation, TUCSON, Ariz., Sept. 26 ... limited-English speaking patients in,hospitals and health care ... of the industry,s first dual-handset cordless phone,ClearLink(TM) ... of its patented,dual-handset phone now known as ...
... Trials and Commercialization, PALO ALTO, Calif., Sept. ... a late-stage biotechnology company that,develops central nervous system ... conducted an initial closing of its,private offering of ... gross proceeds of $3,110,000 and in exchange sold,3,110 ...
... BV, a world leader in,the rapidly evolving field of ... Personalized Medicine Coalition (PMC). "The PMC is playing ... on,personalized medicine. We are very pleased to be a ... of patients in the future. After we,got both our ...
Cached Biology Technology:Industry-First Telephone for Health Care Developed by CyraCom 2Avicena Group Announces Closing of Private Offering 2Agendia Joins the Personalized Medicine Coalition (PMC) 2
(Date:4/17/2014)... German . Our ... provide us with a continuous stream of information about our ... still in a car the world glides by us ... without effort, our brain calculates self-motion from this "optic flow". ... steady gaze during our own movements. Together with biologists from ...
(Date:4/17/2014)... German . If ... of him, he can expect his premises to be trashed. ... the consequences is enough to make restaurant owners pay up. ... their eggs in other birds, nests. If the host birds ... revenge by destroying the entire nest. Consequently, it is beneficial ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
... fever destroys the small farmer's dream of escaping poverty in ... $200 million annually, this tick-borne disease rages across a dozen ... of scientists has taken the first major step toward a ... the February 13-17 early online edition of the Proceedings ...
... quarter century after they discovered it, researchers have identified ... response proteins. The enzyme has puzzled scientists because ... that it is crucial to life, and yet, in ... , The discovery suggests that the enigmatic enzyme known ...
... (miRNAs) that appear to play a significant role in ... body's ability to form clots following an injury. They ... abnormally, may contribute to certain forms of leukemia. , ... genes are turned off in normal platelet development, but ...
Cached Biology News:Genomics-based vaccine could prevent deadly cattle disease 2Genomics-based vaccine could prevent deadly cattle disease 3Common enzyme is a key player in DNA repair 2Common enzyme is a key player in DNA repair 3MiRNA fingerprint identified in platelet formation 2