Navigation Links
Cardiovascular Side Effects of Pioglitazone and Rosiglitazone Linked to Vascular and Energy Pathways by Genomas Clinical Study
Date:1/21/2009

Basis Established for DNA-Guided Decision Support in Diabetes Drug Therapy

HARTFORD, Conn., Jan. 21 /PRNewswire/ -- Research by Genomas has shown statistically significant associations of certain genes in vascular and energy pathways to body mass index (BMI) and edema (fluid retention) in patients taking the thiazolidinedione (TZD) drugs pioglitazone and rosiglitazone. The study, co-authored with investigators from Joslin Diabetes Center Affiliate at The Hospital of Central Connecticut, Hartford Hospital and Yale, appears in the February 2009 issue of the leading laboratory medicine journal Clinica Chimica Acta. The findings are being used to develop a DNA-guided decision support system for diabetic pharmacotherapy.

TZDs are powerful diabetes drugs currently utilized in patients failing first-line therapy with metformin and sulfonylureas. Patients given TZDs typically are at greater risk of diabetic complications and represent an advanced stage of the disease. However, TZDs have been observed to have side effects of weight gain and abdominal obesity, which exacerbate the diabetic condition itself, and to cause edema and exacerbate congestive heart failure in certain patients. Individuals vary in their risk and there is no known method for predicting such side effects. FDA-mandated "black box" warnings on the drug labels underscore the urgent need to better understand the mechanisms underlying these potentially serious side effects. Uncertainties surrounding the use of these drugs may place patients at risk, reduce patient compliance, burden medical management and increase healthcare costs.

The study involved an analysis of patients taking either pioglitazone or rosiglitazone. A total of 222 cardiometabolic and neuroendocrine genes were selected and a physiogenomic analysis was performed. For BMI, the strongest associations were found among genes involved in energy homeostasis, adi
'/>"/>

SOURCE Genomas Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Legendary Earvin Magic Johnson Joins AFL/Signalife Cardiovascular Protection Team
2. Edwards Lifesciences Grants UC Irvine $5 Million to Establish the Edwards Lifesciences Center for Advanced Cardiovascular Technology
3. NFL Hall of Fame Legend Fred Biletnikoff Joins AFL/Signalife Cardiovascular Protection Team
4. Amarin Announces Initiation of Cardiovascular Development Strategy
5. VIA Pharmaceuticals Lead Compound, VIA-2291, Chosen as a Top Ten Most Licensable Cardiovascular Program for Windhover Informations Therapeutic Area Partnerships Conference
6. VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease
7. GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes
8. HealthAware Introduces Its VascularAware Cardiovascular Disease Module
9. Significant Reductions in Mortality and Cardiovascular Events Shown Using Blood Pressure-Lowering Treatment in Those Aged 80 and Over
10. BRISTOL-MYERS SQUIBB SELECTS ISIS DRUG TARGETING PCSK9 AS DEVELOPMENT CANDIDATE FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE
11. CardioVascular BioTherapeutics, Inc. Announces Update on Timing of Form 10-K Filing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... -- Aethlon Medical, Inc. (Nasdaq: AEMD ), the pioneer ... today announced that it will host its First Quarter ... August 13, 2015 at 4:30 p.m. Eastern Time. ... of fiscal 2016 first quarter results.  A recorded version ... after the call at the Investor Relations portion of ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... TLD5000 diaphragm vacuum pumps to its comprehensive line of analytical laboratory equipment. With ... valves, these versatile pumps provide a chemically resistant and maintenance-free solution for a ...
(Date:7/30/2015)... ... ... Ralco is honored to announce that it is the primary sponsor of ... 5-9 in Marshall. The Ralco Enrichment Center is an interactive experience where the public ... daily lives. This unique exhibit also features a birthing center for fair goers to ...
(Date:7/30/2015)... Washington , July 30, 2015 ... Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial ... Discovery & Development, Preclinical, Clinical Trial), by End Users ... Biosimulation Market is expected to reach USD 2,107.99 million ... a CAGR of 15.29%. Browse more ...
Breaking Biology Technology:Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2Sterlitech Launches New Line of Vacuum Pumps 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4
... ViroPharma Incorporated,s (Nasdaq: VPHM ) second quarter financial results for 2010 are expected ... the U.S. financial markets. , , , ... a conference call and live audio webcast at 9:00 a.m. Eastern Time ... second quarter financial results and other business. , ...
... DALLAS , July 21, 2010 ... Market - Advanced Technologies, Global,Forecast and Winning Imperatives (2009-2014)", ... is,expected to reach a $8.3 billion by ... knowledge management formed the largest submarket is 2009 at, ...
... 2010The Life Sciences Discovery Fund (LSDF) today announced ... teams to support commercial development of health-related technologies. ... success rate of lumbar punctures (spinal taps) in ... resonance imaging (MRI) contrast agent; enhancing a DNA ...
Cached Biology Technology:ViroPharma to Release 2010 Second Quarter Financial Results on July 28, 2010 2MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 2MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 3MarketsandMarkets: Global Bioinformatics Market Worth $8.3 billion by 2014 4Life Sciences Discovery Fund announces commercialization grants 2
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
(Date:7/8/2015)... The consumer products industry for innovative ... products such as wearables, smart wallets & other smart technology ... devices continues to rapidly grow.  Biometrics & Wearable Device Companies ... Google Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... (NASDAQ: GPRO ) and Baidu Inc. (NASDAQ: BIDU ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... of environmental conditions over the Atlantic Ocean shows that ... Sahara desert was a likely contributor to the quieter-than-expected ... number and intensity of hurricanes in a season, including ... pressure, led to NOAA forecasts [identify what agency made ...
... Institute for the Environment has awarded five faculty planning ... help solve the world,s urgent demands for fresh water. ... well-being, yet in poor countries more than a billion ... more than 2 billion lack basic sanitation facilities," said ...
... that cause blood to clot and scabs to form when ... promoting cerebral malaria, an often lethal complication that occurs mostly ... in tropical and subtropical regions, malaria is one of the ... among the most studied pathogens of all time. Still, cerebral ...
Cached Biology News:2007 hurricane forecasts took blow from winds and Saharan dry, dusty air 22007 hurricane forecasts took blow from winds and Saharan dry, dusty air 3New planning grants to fund research on freshwater issues 2New planning grants to fund research on freshwater issues 3Johns Hopkins scientists discover what drives the development of a fatal form of malaria 2
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
... Immunogen KLH-conjugated, ... acids 47-66 (PAEV-GPGAVGERTPRKKEPP) of human ... 1 (BHC110/LSD1). Quality Assurance ... Stability 2 ...
...
Biology Products: