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Cardio3 BioSciences Publishes the Science Basis for C-Cure(R) in JACC
Date:8/16/2010

Mayo approach as a "boot camp" for stem cells and that the study "...provides the first convincing evidence that MSCs, at least in vitro, can in fact become functional cardiomyocytes (heart cells)..."

Cardio3 BioSciences has advanced the development of this technology with the recent conclusion of a Phase II clinical trial that recruited 45 heart failure patients in Europe. The Company recently announced that its lead compound C-Cure had an excellent safety profile and observed positive trends in both physiological and clinical heart function, as was anticipated from the animal model data published in JACC. C-Cure's unique repair action on heart muscle is projected to yield clinical benefits in a Phase III trial setting.

Dr Christian Homsy, CEO of Cardio3 BioSciences said: "Publication of this research in a journal as prestigious as JACC highlights the quality of the science underlying our lead product. This trans-Atlantic effort involving leading edge science in both the US and Belgium served to dramatically increase the potency of human stem cells to repair heart tissue and provides the basis for C-Cure, a therapy that could revolutionize the treatment of this devastating disease.

"Based on this world-class science and the insights and confidence we have gained from our first clinical trial, we are now finalising the design of our pivotal clinical program for C-Cure and look forward to continuing to steps needed to bring this much needed treatment to patients."

The research was supported by the National Institutes of Health, the American Heart Association, the Marriott Heart Disease Research Program, Cardio3 BioSciences, the Ted Nash Long Life Foundation, the Ralph Wilson Medical Research Foundation, the Mayo Clinic General Mills Clinician-Investigator Fellowship, and Mayo Clinic.

The paper's authors include Atta Behfar, M.D., Ph.D., Satsuki Yamada, M.D., Ph.D., Ruben Crespo-Diaz, Jonathan Nesbitt, Lois Rowe,

SOURCE Cardio3 BioSciences
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1. Cardio3 BioSciences Reports Positive Three-Month Data From its Clinical Trial of C-Cure(R) in Heart Failure
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3. Cardio3 BioSciences Presents Update on C-Cure(R) Second Generation Stem Cell Therapy for Heart Failure at European Society of Cardiology Congress
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