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Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation
Date:5/28/2009

available commercial assays for a given set of protein biomarker candidates, the MRM technique offers a faster and more cost-effective alternative to established enzyme-linked immunosorbant assay (ELISA) development approaches. MRM assays can be developed within a matter of weeks and enables the quantitative parallel tracking of large numbers of biomarker candidates through a multiplex high-throughput format. This technique, therefore, has the potential to unlock significant value from the scores of genomics, proteomics and other biomarker candidates that have not yet progressed to the validation stage.

The mass-spectrometry-based technique can also prove advantageous in cases where specificity is required and specific post translational modifications or protein isoforms are critical to monitor but difficult to differentiate by antibody techniques.

This joint effort is another example of both companies working with industry leaders to help fulfill the promise of proteomics for a variety of applications, such as personalized medicine, clinical pharmacology and diagnostics. By extending its best-in-class service for biomarker advancement beyond the discovery phase into validation and assay development, Caprion is building on its momentum created by its exclusive strategic alliance on proteomic biomarkers with Covance Inc., as well as its vast experience in the field, including work on more than 30 biomarker studies for 20 large pharmaceutical and biotech clients, plus two large multi-year, multi-million dollar bio-defense contracts for the NIH-NIAID.

"With the advent of MRM assays, which we have now put into practice with the help of QTRAP technology, we are changing the way scientists view biomarker research by offering superior services that make it more cost-effective and productive for pharmaceutical and biotech organizations to not only undertake biomarker programs, but to carry them through to their intended
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SOURCE Caprion Proteomics Inc.
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