Navigation Links
Canadian researchers discover gene related to the appearance of aging
Date:7/15/2009

HALIFAX, July 15 /PRNewswire/ - Scientists in Atlantic Canada have found a gene that may play a role in skin aging. Researchers were investigating the genetic cause of a rare disorder known as cutis laxa type 2 (CL2), which causes skin on the hands, feet and face to be loose and older looking, as well as growth and developmental delays including effects on the brain. In the process, researchers found some interesting correlations with the synthesis of proline, a chemical associated with skin and joint health.

The findings are published in the current online issue of American Journal of Human Genetics (www.cell.com/AJHG), and are part of the Atlantic Medical Genetic and Genomics Initiative (AMGGI), an ambitious, multi-partner gene-discovery project, managed by Genome Atlantic, and funded by Genome Canada/Genome Atlantic, Capital Health, IWK Health Centre, Dalhousie University, Nova Scotia Research Innovation Trust, Dalhousie Medical Research Fund, Nova Scotia Health Research Foundation and others as listed at www.amggi.ca.

Several Maritime Canadian families with CL2 were identified by clinicians at the IWK Health Centre's Maritime Medical Genetics service. Through genomic research, scientists were able to identify the gene responsible for CL2 in these patients, citing an interruption of the metabolism of the amino acid, proline. The gene, pyrroline-5-carboxylate reductase 1, carries out the final step of proline synthesis.

Proline is a major component of connective tissue and skin proteins, collagen and elastin. It can be created by the body, and is also found in our diets. Some skin creams, cosmetics and vitamin supplements already include proline, touting its health benefits.

However, proline is not completely understood. Researchers know that it helps make 'kinks' in protein chains, critical for correct folding of these proteins. But it seems to play an independent role in protection from cellular stress. Proline made internally in our bodies may have a biological role distinct from that of dietary proline.

"This reinforces our understanding of proline as an integral part of skin health," says Dr. Mark Samuels, AMGGI co-lead. "It provides the impetus for further work that could help us understand the development of skin, the largest, and one of the most complex organs of the body. It shows that you can't mess with proline without causing a dramatic effect on many systems, including brain development."

The gene is one of six novel discoveries made to date through the AMGGI project. Among them, a gene related to sudden cardiac death in Newfoundland and Labrador and one linked to haemoglobin production.


'/>"/>
SOURCE Genome Atlantic
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. BioMS Medical to present at the 2009 Symposium for the Canadian Society for Pharmaceutical Sciences
2. Canadian research team reports major breakthrough in lithium battery technology
3. DuPont Receives Canadian Regulatory Approval for High Oleic Soybean Trait
4. Vancouver General Hospital is the First Canadian Institution to Implement Copan WASP(R): Walk-Away Specimen Processor
5. Canadian Government Announces Funding for Leading Biotechnology Firms Project
6. Leading Canadian Scientist to speak at UN Climate Change Conference
7. GeneNews appoints Canadian Colorectal Cancer Advisory Board
8. Medizone International, Inc. Announces Establishment of Canadian Foundation for Global Health
9. BioElectronics Announces Significant Progress in Canadian and International Distribution
10. Reliant Technologies Announces Canadian Launch of Fraxel re:pair(R) Laser: A New Class of Treatment Therapy for CO2 Laser Skin Resurfacing
11. Healthation Chosen by Large Canadian Third Party Administrator to Support All Employee Benefits and Claims Administration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... , Feb. 28, 2017  Phosphorus, a ... today the formation of the Phosphorus Scientific Advisory ... experts chosen to advise the company on the ... multi-site research initiatives. Please visit http://phosphorus.com/about-us/ ... initiatives. "We,ve gathered some of the ...
(Date:2/28/2017)... WuXi AppTec, a leading global pharmaceutical, ... platform company, today announced that its Lab Testing ... once again passed US FDA,s bioequivalence (BE) ... inspectors from FDA thoroughly audited WuXi,s quality system ... integrity, operation infrastructure, equipment, sample storage, archival system, ...
(Date:2/28/2017)... ... February 28, 2017 , ... ACEA Biosciences, a pioneer ... chronic diseases, has announced Dr. Roger (Feng) Luo as the new Vice President of ... a number of multinational drug companies, Dr. Luo will now team with Dr. Li ...
(Date:2/28/2017)... , Feb. 28, 2017 AMO Pharma Limited ... debilitating diseases including rare genetic diseases with limited or ... with the National Organization for Rare Diseases (NORD) and ... world in commemorating Rare Disease Day, the annual observance ... the millions of patients and families affected by rare ...
Breaking Biology Technology:
(Date:2/3/2017)... ANTONIO , Feb. 3, 2017  Texas Biomedical Research ... Dr. Larry Schlesinger as the Institute,s new ... Texas Biomed effective May 31, 2017. He is currently the ... Director of the Center for Microbial Interface Biology at Ohio ... Schlesinger as the new President and CEO of Texas Biomed," ...
(Date:2/1/2017)... IDTechEx Research, a leading provider of independent ... availability of a new report, Sensors for Robotics: Technologies, Markets ... ... ... IDTechEx Report "Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine ...
(Date:1/25/2017)... The Elements of Enterprise Information Security ... of a comprehensive set of business processes and ... identities and providing a secured and documented access ... number of programs opted by enterprises to maintain ... processes and changing policies. However, there are some ...
Breaking Biology News(10 mins):