Navigation Links
Canadian researchers discover gene related to the appearance of aging
Date:7/15/2009

HALIFAX, July 15 /PRNewswire/ - Scientists in Atlantic Canada have found a gene that may play a role in skin aging. Researchers were investigating the genetic cause of a rare disorder known as cutis laxa type 2 (CL2), which causes skin on the hands, feet and face to be loose and older looking, as well as growth and developmental delays including effects on the brain. In the process, researchers found some interesting correlations with the synthesis of proline, a chemical associated with skin and joint health.

The findings are published in the current online issue of American Journal of Human Genetics (www.cell.com/AJHG), and are part of the Atlantic Medical Genetic and Genomics Initiative (AMGGI), an ambitious, multi-partner gene-discovery project, managed by Genome Atlantic, and funded by Genome Canada/Genome Atlantic, Capital Health, IWK Health Centre, Dalhousie University, Nova Scotia Research Innovation Trust, Dalhousie Medical Research Fund, Nova Scotia Health Research Foundation and others as listed at www.amggi.ca.

Several Maritime Canadian families with CL2 were identified by clinicians at the IWK Health Centre's Maritime Medical Genetics service. Through genomic research, scientists were able to identify the gene responsible for CL2 in these patients, citing an interruption of the metabolism of the amino acid, proline. The gene, pyrroline-5-carboxylate reductase 1, carries out the final step of proline synthesis.

Proline is a major component of connective tissue and skin proteins, collagen and elastin. It can be created by the body, and is also found in our diets. Some skin creams, cosmetics and vitamin supplements already include proline, touting its health benefits.

However, proline is not completely understood. Researchers know that it helps make 'kinks' in protein chains, critical for correct folding of these proteins. But it seems to play an independent role in protection from cellular stress. Proline made internally in our bodies may have a biological role distinct from that of dietary proline.

"This reinforces our understanding of proline as an integral part of skin health," says Dr. Mark Samuels, AMGGI co-lead. "It provides the impetus for further work that could help us understand the development of skin, the largest, and one of the most complex organs of the body. It shows that you can't mess with proline without causing a dramatic effect on many systems, including brain development."

The gene is one of six novel discoveries made to date through the AMGGI project. Among them, a gene related to sudden cardiac death in Newfoundland and Labrador and one linked to haemoglobin production.


'/>"/>
SOURCE Genome Atlantic
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. BioMS Medical to present at the 2009 Symposium for the Canadian Society for Pharmaceutical Sciences
2. Canadian research team reports major breakthrough in lithium battery technology
3. DuPont Receives Canadian Regulatory Approval for High Oleic Soybean Trait
4. Vancouver General Hospital is the First Canadian Institution to Implement Copan WASP(R): Walk-Away Specimen Processor
5. Canadian Government Announces Funding for Leading Biotechnology Firms Project
6. Leading Canadian Scientist to speak at UN Climate Change Conference
7. GeneNews appoints Canadian Colorectal Cancer Advisory Board
8. Medizone International, Inc. Announces Establishment of Canadian Foundation for Global Health
9. BioElectronics Announces Significant Progress in Canadian and International Distribution
10. Reliant Technologies Announces Canadian Launch of Fraxel re:pair(R) Laser: A New Class of Treatment Therapy for CO2 Laser Skin Resurfacing
11. Healthation Chosen by Large Canadian Third Party Administrator to Support All Employee Benefits and Claims Administration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 30, 2016 , ... The MIT bioLogic design team has ... team explored how bacterial properties can be applied to fabric and formed into living ... move in response to humidity change. The team harvested Natto cells and applied them ...
(Date:4/29/2016)... , April 29, 2016 ... Transparency Market Research "Separation Systems for Commercial Biotechnology ... Trends, and Forecast 2015 - 2023", the separation ... US$ 10,665.5 Mn in 2014 and is projected ... 2015 to 2023 to reach US$ 19,227.8 Mn ...
(Date:4/29/2016)... ... ... Intelligent Implant Systems announced today that the two-level components for the Revolution™ Spinal System ... These components expand the capabilities of the system and allow Revolution™ to be utilized ... the company has seen significant sales growth in 1Q 2016, and the system is ...
(Date:4/28/2016)... , April 28, 2016 ... reports the Company,s CEO  was featured in an ... Enter When VCs Fear To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... magazine is an essential business journal ... from emerging biotechs to Big Pharmas. Their content ...
Breaking Biology Technology:
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/17/2016)... 2016 ABI Research, the leader in ... biometrics market will reach more than $30 billion ... 2015. Consumer electronics, particularly smartphones, continue to boost ... to reach two billion shipments by 2021 at ... , Research Analyst at ABI Research. "Surveillance is ...
(Date:3/11/2016)... http://www.apimages.com ) - --> http://www.apimages.com ) - ... ( http://www.apimages.com ) - Germany . The ... refugee identity cards. DERMALOG will be unveiling this device, and a ... next week.   --> Germany . ... new refugee identity cards. DERMALOG will be unveiling this device, and ...
Breaking Biology News(10 mins):