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Calithera Biosciences Presents Preclinical Data for CB-839 at the 55th American Society of Hematology Annual Meeting
Date:12/10/2013

SOUTH SAN FRANCISCO, Calif., Dec. 10, 2013 /PRNewswire/ -- Calithera Biosciences, a biotechnology company focused on the development of novel cancer therapeutics, today announced the presentation of preclinical data for its lead anti-cancer therapeutic candidate, CB-839, at the 55th American Society of Hematology (ASH) Annual Meeting.  CB-839 is a potent, selective, orally available glutaminase inhibitor that interferes with tumor metabolism and blocks cancer cell growth and survival. 

"Glutaminase is an enzyme responsible for converting glutamine into a form that can be used by cells for energy production and the synthesis of macromolecules.  Many tumor types rely on glutamine for growth and survival, so with CB-839, we hope to block glutaminase activity and thereby starve the tumor of its energy source," said Susan Molineaux, PhD, President and Chief Executive Officer of Calithera Biosciences.  "The data being presented at ASH demonstrate that CB-839 is a potent inhibitor of glutaminase and provide strong evidence for its potential therapeutic benefit in treating patients with hematologic malignancies.  We look forward to advancing CB-839 into Phase 1 studies in hematological patient populations early next year."

Calithera researchers evaluated the anti-tumor activity of CB-839 in diverse cell lines of B-cell malignancies including multiple myeloma, acute lymphocytic leukemia, and non-Hodgkin's lymphoma.  Treatment with CB-839 had anti-proliferative effects on the majority of tumor cell lines evaluated (36 out of 44) and induced cell death in a significant fraction of those cell lines.   In a xenograft model of multiple myeloma, oral twice-daily dosing of CB-839 resulted in a 70 percent inhibition of tumor growth.  Anti-tumor activity was dose dependent and was correlated with tumor glutamine accumulation, tumor glutamate dec
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