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Caliper Life Sciences Receives $1.1 Million Task Order from the EPA's ToxCast(TM) Screening Program
Date:8/19/2008

he first phase. Based on these efforts, the ToxCast screening program will provide the EPA with an efficient tool for rapidly and efficiently screening compounds and prioritizing further toxicity testing. The ultimate goal is to identify a set of predictive in vitro assays that can supplement or replace in vivo tests currently used for regulatory approval of new environmental chemicals.

"Caliper's test results from the initial phase of the ToxCast screening program provided high quality data and demonstrated a substantial number of positive results, or 'hits,' that may have potential relevance to environmental toxicity or adverse effects. With this new funding, we will expand our testing to determine the potency, or concentration response, of these bioactivities using all 230 of the initial assays," said David Manyak, Ph.D., executive vice president of discovery services at Caliper Life Sciences. "This follow-up screening is an important step in the progress of the ToxCast program. We look forward to continuing our research efforts and supporting the EPA's efforts to better understand the impact, and minimize the threat, of environmental contaminants."

Earlier in 2008, the EPA and National Institutes of Health (NIH) announced a collaboration intended to broaden the scope of the ToxCast screening program beyond the EPA, further emphasizing the growing national significance of this initiative. Caliper was selected and will present the methodology and validated results of a series of toxicology-related cell-based assays at the National Toxicology Program's Request for Information Meeting, to be held on September 11-12 in North Carolina. The event is sponsored by the National Institute of Environmental Health Sciences (NIEHS), one of the two lead agencies within National Institutes of Health (NIH) spearheading the collaboration with EPA.

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