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Caliper Life Sciences Forms Alliance With Horizon Discovery to Provide Enhanced Solutions for Cancer Research Based on Isogenic Cell Lines
Date:4/9/2008

iferation panel, and the ability to correlate results from these isogenic cell lines to efficacy in specific patient populations, further solidifies Caliper's in vitro-in vivo-human (IIH) bridge. Access to these tools will enable researchers to enhance the success rate and reduce the cost of discovering targeted monotherapy or combination therapies that better treat disease with fewer adverse events."

Rather than being a single disease, researchers now understand that there are numerous forms of cancer, many of which are associated with specific genetic alterations among cancer patient subpopulations. The discovery of targeted or personalized medicines that treat patients with a specific genetic makeup is a long and difficult process. Using more predictive cellular models that better reflect the complexity of biological systems will accelerate and rationalize many aspects of the discovery process -- including target selection, lead-compound generation and identification of the most responsive patients for clinical studies. The availability of such models also enables molecular diagnostic findings to be incorporated into existing drug discovery processes.

"Our extensive panel of isogenic human cancer cell-lines is a key, previously missing, tool in understanding the link between drug behavior and patients' genetic mutations. Our partnership with Caliper allows us to greatly expand the reach of our cell lines to assist researchers that are focused on uncovering cancer therapies," said Chris Torrance, CEO, Horizon Discovery. "Together we aim to significantly accelerate the search for new and more effective targeted or personalized drugs."

About Horizon Discovery

Horizon Discovery is a translational genomics company founded in June 2007 and is headquartered at the Babraham Research Campus, Cambridge, UK and with additional research laboratories in Torino, Italy. Horizon's goal is to convert new information on the genetic causes of cancer into
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SOURCE Caliper Life Sciences, Inc.
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