The two groups previously worked together to conduct experiments aimed at transplanting high purity human stem cell progenitor motor neurons, into the spinal cords of SOD1 mice, which are genetically engineered to exhibit the neuronal deterioration and mimic ALS. The results of those studies showed that the cells survive, integrate, and display markers of motor neurons when transplanted into the SOD1 mouse model.
"ALS TDI's expertise in ALS disease biology and their world-class screening facility make them an ideal partner to collaborate with in order to understand the use and benefit of our MotorGraft™ technology in treating ALS. We know we have the most stable and pure population of stem cell derived motor neuron progenitors available in the world, and are excited to see if it can be used to help fight this terrible disease," said Chris Airriess, chief operating officer for California Stem Cell.
ALS, also known as Lou Gehrig's disease, is a neurodegenerative disease resulting in progressive paralysis and is considered fatal. The disease strikes typically without an identifiable cause, indiscriminately affecting a new family every 90 minutes in the U.S. That incidence rate is similar to that of multiple sclerosis, but the typical survival prognosis given to a new ALS patient is only 2-5 years from their date of diagnosis. Currently, there is no known cure for ALS and only one FDA-approved drug, with marginal efficacy, for treating the disease.
California Stem Cell recently presented the findings of previous work done with ALS TDI to the FDA, as part of an a Pre-Investigational New Drug meeting to discuss
|SOURCE ALS Therapy Development Foundation|
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