Navigation Links
CV Therapeutics Initiates Phase 1 Clinical Trial of CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases
Date:9/2/2008

PALO ALTO, Calif., Sept. 2 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: CVTX) announced today that the company has enrolled the first patient in a Phase 1 trial of CVT-3619, a novel oral compound for potential treatment of cardiometabolic diseases. The U.S. Food and Drug Administration recently accepted the Company's investigational new drug application for CVT-3619, a partial A1 adenosine receptor agonist.

This Phase 1 trial will assess the safety and pharmacokinetic profile of CVT-3619 in healthy volunteers. The Phase 1 program will provide early data on the compound's potential effects on circulating levels of free fatty acids, which are associated with high blood lipid levels, insulin resistance and other cardiometabolic risk factors.

"Despite current therapies, millions of Americans continue to suffer from both heart disease and diabetes. CVT-3619 is a first in class, potent, orally available new chemical entity that targets yet untreatable aspects of dysfunctional metabolism in these patients," said Louis G. Lange, M.D., Ph.D., chairman and chief executive officer of CV Therapeutics. "CVT-3619 was invented by CV Therapeutics and represents our fourth clinical program to complement our two approved products."

CVT-3619 binds to the adenosine A1 receptor on fat cells, called adipocytes, potentially leading to a reduction in the breakdown in fats, also known as lipolysis, and a lowering of free fatty acids in preclinical models. Preclinical studies also have shown that CVT-3619 improves insulin sensitivity, reduces elevated triglycerides, and may lower very low density lipoproteins and potentially raise high density lipoproteins.

"CVT-3619 represents a first-in-class agent that appears to inhibit
'/>"/>

SOURCE CV Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3

Related biology technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. DJO Incorporateds Pending Merger With ReAble Therapeutics Clears U.S. Antitrust Review
3. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
4. Systems Medicine (SM), a Subsidiary of Cell Therapeutics, Inc. (CTI), Announces Execution of CRADA with NCI/NIH to Develop Potential Cancer Treatments Targeting the Insulin Growth Factor (IGF) Pathway
5. Amsterdam Molecular Therapeutics to Release H1 2007 Results on August 29, 2007
6. Nektar Therapeutics Appoints Tim Harkness as Chief Financial Officer
7. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
8. Cell Therapeutics, Inc. Takes Corrective Actions in Response to Nasdaq Determination
9. Amsterdam Molecular Therapeutics Reports Half Year Results 2007
10. Nektar Therapeutics Appoints Lutz Lingnau as New Board Member
11. Anesiva Grants Specific-Use License of Its Needle-Free Drug Delivery Technology to Particle Therapeutics for Diabetes Drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... , May 21, 2013  The Lindsley F. Kimball Research ... it is a Grand Challenges Explorations winner, an ... .  Dr. Sara Lustigman , Head of ... health and development research project, titled Innovative 3-D ... worms are needed to screen drugs to help eliminate onchocerciasis ...
(Date:5/21/2013)... results of a new study led by George ... evidence that nucleation of ice in small droplets ... water,s behavior at the nanoscale. The formation of ... scientific research question whose answer also has important ... , The crystallization of ice from supercooled water ...
(Date:5/21/2013)... Savoury Systems International (SSI), a leader ... to Southeastern USA Sales Broker. Braddy’s new role will ... the Southeast. , In 2004 Braddy founded ... to food processors and industrial manufacturers. Braddy has ... industry and has over 25 years of sales management ...
(Date:5/21/2013)... 2013 According to a new ... ) "Biochip Products and Services Market (Microarrays, Reagents, Drug ... Size, Share, Growth, Trends and Forecast, 2012 - 2018," the market was ... expected to grow at a CAGR of 10.1% from ... USD 4.7 billion in 2018. Browse the ...
Breaking Biology Technology:New York Blood Center's Research Institute Receives Grand Challenges Explorations Grant For Groundbreaking Research in Global Health and Development 2New York Blood Center's Research Institute Receives Grand Challenges Explorations Grant For Groundbreaking Research in Global Health and Development 3Study led by GW professor provides better understanding of water's freezing behavior at nanoscale 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5
... March 4 deCODE genetics,Inc. (Nasdaq: DCGN ) today ... a press release to be issued on Wednesday, March 12,after ... will host a live,webcast of its conference call to discuss ... 8 am EDT / 12 noon GMT., The webcast ...
... Dr. Siddharth Advant Appointed Head of West Coast ... Continuing its leadership,as an advisor to the ... has appointed Siddharth Advant, Ph.D., as head of ... Dr. Advant brings more,than a decade of process ...
... new independent non-executive directors added to Board with ... ... appointed independent non-executive Chairman, BRISBANE, Australia, March 4 ... John Lee and Robert Williamson to the Company,s Board as,independent ...
Cached Biology Technology:deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results 2Tunnell Consulting Expands Biotechnology Expertise 2Tunnell Consulting Expands Biotechnology Expertise 3Progen Expands Board of Directors 2Progen Expands Board of Directors 3Progen Expands Board of Directors 4
(Date:5/22/2013)... responsible for legionellosis, an infectious disease that can lead ... has developed a complex method enabling it to camouflage ... these acting against the infectious bacteria. , Research led ... which teams from the National Institute of Health (NIH) ... Barcelona (BSC) have also participated, has described for the ...
(Date:5/22/2013)... new details on how climate change will affect interactions ... the Journal of Animal Ecology . This knowledge, ... informing policymakers of how species are likely to be ... a growing recognition among biologists that climate change is ... this is going to have very important consequences for ...
(Date:5/22/2013)... May 22, 2013 Early screening for prostate cancer ... testing is for women, thanks to UC Irvine research ... Chemical Society . , After more than a decade ... to clearly identify clinically usable markers for prostate cancer ... far sooner, with greater accuracy and at dramatically lower ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2UCLA life scientists present new insights on climate change and species interactions 2UCLA life scientists present new insights on climate change and species interactions 3UCLA life scientists present new insights on climate change and species interactions 4UCLA life scientists present new insights on climate change and species interactions 5UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3
... people prefer to wipe the venomous little varmints off the face ... yards. The reviled South American native that invaded the U.S. Sun ... Solenopsis invicta and everywhere else as a painful pest in the ... An ardent fire ant fan and one of its foremost researchers ...
... genes influence the development and use of neural circuits ... the fruit fly, researchers have provided new insight into ... prior experience ?arise in the developing nervous system. The ... of Stephen Goodwin's group at the University of Glasgow, ...
... discovery of a novel class of mutations that disrupt the ... The mutation created the appearance of an "illegitimate" microRNA (miRNA) ... in its normal form. In this study, the gene ... skeletal muscle and the function of the derived protein is ...
Cached Biology News:Fire ants: Their true story told by the scientist who loves them 2Fire ants: Their true story told by the scientist who loves them 3Fly's courtship sheds light on the formation of innate behaviors 2
... 9 oligodeoxynucleotides are random ... at the 5' end ... Fluor dyes and they ... microarray spot morphology, hybridization ...
Mycoplasma tested...
The Spheroplast Kit contains qualified reagents for the preparation of yeast spheroplasts. The reagents have been optimized for use with Pichia pastoris and are guaranteed to generate 70% spheroplast...
... Our fastest automated perfusion system. For ... perfusion, physiology, biophysics, electrochemistry, or general ... with 1.5-4 millisecond accuracy Run ... Microprocessor-based for accuracy and flexibility ...
Biology Products: