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CSL Behring Signs Agreements With Canadian Blood Services and Hema-Quebec to Supply Life-Saving Therapies
Date:4/3/2008

ise von Willebrand factor in the bloodstream(ii).

About Helixate(R) FS and Humate-P(R)

Helixate(R) FS is a recombinant version of the human factor VIII (FVIII) produced with the help of baby hamster kidney (BHK) cells. It is used to treat hemophilia A when there is a demonstrated deficiency of the above mentioned factor FVIII, a plasma clotting factor. Helixate(R) FS should be administered cautiously in patients with previous hypersensitivity to constituents of FVIII preparations or known sensitivity to mouse or hamster protein.

Helixate(R) FS should not be used to treat people with VWD since it does not contain the von Willebrand factor, the endogenous protein which is absent or defective in the VWD. For more information about von Willebrand disease, please visit http://www.allaboutbleeding.com.

Adverse events related to the use of Helixate (R) FS are generally minor. The most common events include injection-site reactions, dizziness and rash.

Humate-P(R) is a stable, purified, sterile, lyophilized concentrate of Antihemophilic Factor (Human) and von Willebrand Factor (vWF) (Human) complex used for the treatment of patients with classical hemophilia (hemophilia A) and VWD.

Humate-P(R) is usually tolerated without reaction. It should be administered with caution to patients with a known allergic reaction to constituents of the preparation. Cases of allergic reactions and rise in body temperature have been observed. Anaphylactic reactions can occur in rare instances. Thromboembolic events have been reported in VWD patients receiving coagulation factor replacement, especially in the setting of known risk factors for thrombosis. Caution should be exercised and antithrombotic measures considered.

Humate-P(R) is made from human plasma and there is a theoretical risk that it may contain pathogens susceptible to cause diseases such as the hepatitis viruses, HIV and,
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