Navigation Links
CNIO researchers take part in the most comprehensive personalized medicine study performed to date

time a cell divides. Telomeres are structures protecting the end of chromosomes, and their length is a measure of cells' biological age: as a rule, the cells of older organisms have shorter telomeres, while short telomeres are also associated with diabetes and other disorders.

The mutation detected in the telomerase gene is linked to a grave condition known as aplastic anaemia. Snyder does not have it. But Mara Blasco, of the CNIO, and Mercedes Gallardo, who works in Blasco's lab and collaborates with LifeLength, have measured the length of his telomeres and found that he has more short telomeres than is normal for a man of his age.

The team also documented Snyders transcriptome the genes that are actually being read; the levels of over 6,000 proteins in his body; the tens of thousands of compounds derived from the metabolism; and the antibodies present.

These analyses were repeated on some fifteen occasions in the space of a year and a half, making over three billion measurements in all. An unsought bonus was the chance to observe how a viral infection showed up in the results.

Snyder, in effect, contracted two mild viral infections in the data-gathering period, which left their molecular signature in the analyses. Perhaps the most striking observation was that, during one such infection, his blood glucose levels began to approach those of a diabetes sufferer, whereas before they had been normal, despite his genetic risk.

Just the beginning

For CNIO Director Maria Blasco, this study shows that diseases are a product of an individuals genetic profile as well as interaction with the environment. So far we know little about this correlation, while the use of human genome information to prevent and treat disease is still clearly in its infancy. But what we can see the tip of the iceberg is fascinating stuff.

Blasco and Gallardo concur that it would be premature to subject all patients to t

Contact: juanj.gomez
Centro Nacional de Investigaciones Oncologicas (CNIO)

Page: 1 2 3

Related biology technology :

1. Researchers develop graphene supercapacitor holding promise for portable electronics
2. Researchers capture first-ever images of atoms moving in a molecule
3. Penn researchers build first physical metatronic circuit
4. Pitt researchers coax gold into nanowires
5. York researchers create tornados inside electron microscopes
6. Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks
7. Navy researchers investigate small-scale autonomous planetary explorers
8. Notre Dame researchers develop paint-on solar cells
9. Quantum computing has applications in magnetic imaging, say Pitt researchers
10. Researchers measure nanometer scale temperature
11. Notre Dame researchers demonstrate new DNA detection technique
Post Your Comments:
Related Image:
CNIO researchers take part in the most comprehensive personalized medicine study performed to date
(Date:9/16/2014)... 2014 According to Jeff Howell, Partner ... ITRA Global, new development in Downtown Toronto is expanding ... approving another 755 storeys of new development last week ... will be dominating the Toronto skyline for the foreseeable ... unquenchable thirst for new development. , As the Toronto ...
(Date:9/16/2014)... September 16, 2014 RENU 28, the world's ... became available for purchase in Australia and New Zealand ... tour beginning September 16th. The tour will make stops in ... Bundaberg on the 18th, Sydney on the 20th, and Melbourne ... Australia and New Zealand and to educate people about the ...
(Date:9/15/2014)... UPTON, NYHeat drives classical phase transitionsthink solid, ... happen when the temperature drops. If phase ... where quantum mechanics reigns, subtle fluctuations can ... from the U.S. Department of Energy,s Brookhaven ... explored this frigid landscape of absolute zero ...
(Date:9/15/2014)... 2014   Global Science & Technology, Inc. ... and services for satellite and weather systems, was ... Services (OASIS) from the General Services Administration (GSA) ... provide the government best-value solutions for complex professional ... in Pool 4. The OASIS SB award has ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3
... Omni Bio Pharmaceutical, Inc. ("Omni Bio") (OTC Bulletin Board: ... 7,850,970, entitled "Inhibitors of Serine Protease Activity and Their Use ... issued by the United States Patent and Trademark Office (USPTO) ... New Patent is part of the technology licensed to Omni ...
... new method of child and maternal nutrition could prevent a ... up to 160 million brain cells in each person over ... related to aging and cancer. Most people are ... contaminated with a radioactive material from the air known as ...
... YORK, Jan. 4, 2011 announces ... available in its catalogue: ... Strategies for Suppliers,>The 2011 Coagulation Testing Market: ... Market Expansion Strategies for Suppliers ...
Cached Biology Technology:Omni Bio Pharmaceutical Awarded Patent for Preventing Anthrax Infection 2Omni Bio Pharmaceutical Awarded Patent for Preventing Anthrax Infection 3New Method of Nutrition to Permanently Protect Brain Cells from Genetic Damage 2Reportlinker Adds The 2011 Coagulation Testing Market: US, Europe, Japan Emerging Business Opportunities and Market Expansion Strategies for Suppliers 2
(Date:9/15/2014)... leading coral reef ecologists fears that reef biodiversity may ... that we once thought. , In an international study ... of Excellence for Coral Reef Studies (Coral CoE) says ... species within reef ecosystems. , In coral reefs, just ... that keep the ecosystem safe and functioning. , ...
(Date:9/15/2014)... for the first 500 million years after it formed ... complete with oceans, continents and active crustal plates. , ... the Hadean, has gained substantial new support from the ... than 4 billion years ago with those formed contemporaneously ... geological analog for early Earth. , The study was ...
(Date:9/15/2014)... transplanted combinations of wild, domesticated, and domesticated-wild ... new environments found that within 5 to ... genes from wild populations that hybridized with ... study provides evidence that natural selection, ... hybridized populations experience as a result of ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3
... a half-dozen palladium- and iron-based catalysts for cleaning up the ... TCE far faster than iron -- up to a billion ... in a new study in the August issue of the ... trichloroethene, is a widely used chemical degreaser and solvent that,s ...
... Six, the world leader in synthetic diamond supermaterials, ... Departments of Chemistry and Physics, have demonstrated the ... metal-like boron-doped synthetic diamond. The research shows that ... retaining the full strength and durability of its ...
... NANG, VietnamU.S. scientists and Vietnamese researchers will discuss coastal ... the R/V Roger Revelle , an auxiliary general ... port call in the city of Da Nang. ... operated by the Scripps Institution of Oceanography, the advanced ...
Cached Biology News:Palladium-gold nanoparticles clean TCE a billion times faster than iron filings 2Synthetic diamond steps closer to next generation of high performance electrochemical applications 2Synthetic diamond steps closer to next generation of high performance electrochemical applications 3US research vessel winds down visit to Vietnam as part of joint oceanographic research program 2
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
Normal donkey serum collected from healthy normal donkeys....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Biology Products: