Navigation Links
CNIO researchers describe a new target for developing anti-angiogenic and anti-tumoral therapies
Date:6/8/2012

Researchers from the Spanish National Cancer Research Centre (CNIO), led by Jorge L. Martnez-Torrecuadrada from the Proteomics Unit, have demonstrated that the antibody-based blocking of ephrinB2, a protein involved in angiogenesis and lymphoangiogenesis, may represent an effective strategy for the development of antiangiogenic and antitumoural therapies.

The results of this study appeared in this month's issue of Blood, the journal of the American Society of Hematology.

CNIO researchers generated highly-specific human antibodies against ephrin-B2 using a phage display approach. These specific antibodies were able to suppress endothelial cell migration and tube formation in in vitro assays. Also, systemic treatment of mice xenografted with pancreatic, lung or colon carcinoma cells resulted in a significant reduction in the amount of blood and lymphatic vessels.

Concomitantly, a drastic inhibition of the tumour growth was observed in every xenograft mouse model used. Therefore, these results validated ephrinB2 as a potential therapeutic target in tumour angiogenesis and lymphangiogenesis and showed that the ephrinB2-specific antibodies developed in this study may be suitable as leads for the development of new improved antiangiogenic therapies, which can be used alone or can complement or synergise with other established antiangiogenic therapies of application in cancer or other angiogenesis-related pathologies.

The angiogenesis process

Angiogenesis is a complex process by which new blood vascular vessels arise from pre-existing ones. In adulthood and under physiological conditions, this process only occurs in some circumstances, such as wound healing or in the menstrual cycle, but it is also an important factor in several pathologies such as cancer, in which the tumour promotes the formation of new blood vessels. This new vasculature provides the tumour with oxygen and nutrients, allowing these cells to grow, invade nearby tissue and eventually metastasise to distant organs.

In addition to blood vasculature, tumour growth induces the development of lymphatic vessels in a similar process called lymphangiogenesis that plays a key role in tissuefluid homeostasis, as a tissue-drainage system. Recent studies also demonstrated the critical importance of this lymphatic vasculature for the metastatic spread of tumour cells.

In the last decades, the extensive research in the field of tumour-derived angiogenesis led to the identification of several angiogenic targets that can be effectively blocked in order to prevent the formation of new blood vessels in tumours, starving them of oxygen and nutrients and thereby preventing their growth.

As a result of these researches, several antibodies have been successfully developed and have demonstrated clinical utility in treating several tumour types, such as bevacizumab (Avastin), which is based on the inhibition of vascular endothelial growth factor (VEGF) that promotes endothelial cell proliferation, migration and differentiation.

However, recent emerging experimental and clinical evidence suggests that tumours treated with this antiangiogenic strategy may eventually develop resistance to therapy and exhibit a progression to greater invasiveness. Therefore, there is a pressing need to explore other angiogenic targets that can be used therapeutically, such as the one validated by CNIO researchers in the study now published in Blood.


'/>"/>

Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000-4060
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... 2016 /PRNewswire/ - OncoQuest Inc. ("OncoQuest"), a biopharmaceutical ... immunotherapeutic products for the treatment of cancer, today ... Manufacturing Development Program with Cytovance Biologics ( ... oregovomab antibody product. Supported by recent positive interim ... in ovarian cancer patients, OncoQuest has engaged Cytovance ...
(Date:12/7/2016)... , Dec. 7, 2016  Biocom, the association for the ... statement below following passage of 21 st Century Cures ... November 30 by a 392-26 vote and in the Senate ... be attributed to Joe Panetta , president & CEO ... will give hope to millions of patients around the world. ...
(Date:12/7/2016)...  Genprex, Inc. a biopharmaceutical company focused on ... announced that it has retained ICR Healthcare, a ... and advisory firm, to develop and implement an ... investor relations, public relations and digital communications to ... Genprex and its lead candidate Oncoprex, which is ...
(Date:12/7/2016)... Regen BioPharma Inc. (OTCQB: RGBPP) In a recent ... team of scientists in Guangzhou, China ... of NR2F6 in patients with early cervical cancer correlates with ... cancer tissue as well as in the normal tissue surrounding ... study and the first that I am aware of that ...
Breaking Biology Technology:
(Date:12/7/2016)... According to a new market research report "Emotion Detection ... Voice Recognition), Service, Application Area, End User, And Region - Global Forecast to ... 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at a Compound ... ... MarketsandMarkets Logo ...
(Date:12/7/2016)... --  Avanade is helping Williams Martini Racing, one ... exploit biometric data in order to critically analyse every ... edge against their rivals after their impressive, record-breaking pit ... worked with Williams during the 2016 season to capture ... breathing rate, temperature and peak acceleration) for key members ...
(Date:12/6/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... of €500.0 million principal amount of its 1.414% senior unsecured ... 2.425% senior unsecured notes due 2026. The ... 2016, subject to the satisfaction of customary closing conditions.  The ... The Company intends to use the net ...
Breaking Biology News(10 mins):