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CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics
Date:9/7/2011

eclinical, clinical trials, and in-market production. The Company's fully integrated services includes cell line development using its proprietary CHEF1® system, process and formulation development, and comprehensive analytical testing. CMC Biologics has fully segregated microbial fermentation and mammalian cell culture suites and offers stirred tank and perfusion production processes. For more information, please visit www.cmcbio.com.

About the CHEF1® Expression System

The CHEF1 expression plasmid is the technological foundation of CMC Biologics' cell line development platform. Utilizing the regulatory sequences of the Chinese hamster EF-1a (CHEF1) gene, the CHEF1 vectors promote constitutive high-level expression of recombinant proteins early in development and have been successfully used to create manufacturing cell lines expressing a variety of different recombinant proteins, including difficult-to-express glycoproteins. The CHEF1 system allows rapid isolation of stable CHO cell lines because gene amplification is not required to achieve high level expression, saving many months of development. CMC Biologics' CHEF1 cell line development platform delivers stable production-quality cell lines in rapid timeframes, typically producing gram quantities of protein in 7 to 8 weeks from transfection and production-quality clones in 11 to 14 weeks. A variety of CHEF1 vectors are available with different selectable markers permitting expression of heterodimeric proteins as well as modification enzymes to improve product quality or expression levels. The technology behind CHEF1 is proven, having been previously employed for a marketed biologic.

About OGAP®

The Oxford Genome Anatomy Project (OGAP) database represents the world's largest proprietary collection of disease-associated proteins. OGAP oncology contains proteomic data on 5,000 cancer membrane proteins combined with their genomic and clin
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