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CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease
Date:4/27/2009

ation agents, the L.E.A.P.S. activated dendritic cells did not produce the inflammatory cytokines that are usually associated with IL-12 production. Untreated monocytes or monocytes treated with the HSV or HIV portion of the vaccine conjugate alone were unchanged and did not express any of the dendritic cell characteristics.

Dendritic cells direct the subsequent immune response to a vaccine by presenting the vaccine's antigen(s) to the appropriate T lymphocyte and then deliver specific cytokine proteins to the T cell to determine the immune response outcome to the specific vaccine. "L.E.A.P.S. vaccines are unique in their ability to interact with, activate and cause differentiation and maturation of dendritic cell towards a protective immune response without the production of pro-inflammatory cytokines," said Dr. Rosenthal.

The two lead product candidates being developed are CEL-1000 and CEL-2000 from the L.E.A.P.S. technology. CEL-1000 may have broad application for the enhancement of immune responses by individuals who have a poor immune response to vaccinations. It also has application for antigen sparing (reducing the amount/dose of antigen required for protective immunity), and to biodefense and pandemic settings for anti-infectious vaccines. CEL-2000, a L.E.A.P.S. vaccine incorporating a peptide from a rheumatoid arthritis disease protein, was shown to curtail the progression of tissue damage caused by rheumatoid arthritis.

"It is very exciting to see the effect of L.E.A.P.S. vaccines on isolated human immature dendritic cells using a simple molecule, in two different instances," said Dr. Dan Zimmerman, the inventor of the L.E.A.P.S. technology. "I am hopeful that other L.E.A.P.S. vaccine candidates, such as CEL-2000 being developed as a vaccine for rheumatoid arthritis, can also be used with comparable results in humans. The lack of proinflammatory cytokine production in responses to the L.E.A.P.S.
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