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CEL-SCI Corporation Releases Letter to Shareholders
Date:7/7/2009

ncerned about resortment - Egypt. On July 1st, WHO reported that there have been 81 confirmed human cases of H5N1 bird flu in Egypt, of which one-third (27 cases) have been fatal. As the swine flu pandemic rages on, there is a growing risk that H1N1 could find abundant opportunities to swap genes with the bird flu given the prevalence of pigs in Egypt - a common "breeding ground" for viruses that promotes resortment. A further-mutated swine flu virus that combines with the bird flu in Egypt or elsewhere in the world has the potential to be particularly lethal especially if it is Tamiflu-resistant. Knowing this the Egyptian government has been trying to cull the pigs in Egypt, but there has been significant resistance from many groups. History shows that these kinds of government interventions are never completely successful.

That is precisely why we are aggressively pursuing development of the therapeutic and preventative vaccine approaches that our scientists have pioneered. With the world health community perhaps on the verge of losing its third of four flu drug weapons against swine flu - Tamiflu - potentially leaving only Relenza (zanamivir) as the sole option for treatment and prophylaxis, we believe it is critically important to look beyond the swine flu strain originally found to be circulating. We must anticipate its evolution and prepare for mutant strains to appear from remote regions of the globe. Those mutant strains of the virus could possess virulence and other properties that far exceed those of the current strains. We believe the therapeutic and longer-term preventative vaccine approaches we are investigating could address these critical needs. In developing these vaccines, we recognize, as WHO's Director General said in Cancun, "We have the advantages of science, and of rational and rigorous investigation, on our side." We are going to continue leveraging these assets as we try to tackle this persisting and deeply-troubli
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