Navigation Links
CB1400, Patented by Canopus BioPharma, Prevents Tumor Growth and Enhances the Anti-Tumor Effects of Cisplatin and Cetuximab (Erbitux).
Date:6/19/2008

LOS ANGELES, California, June 19 /PRNewswire-FirstCall/ -- Canopus BioPharma, Inc. (OTC: CBIA), has confirmed the efficacy of its oncology candidate, CB1400, as a tumor reducing agent and has also demonstrated the synergistic effect of this drug in combination with both cisplatin and cetuximab (Erbitux) in two mice lung cancer models.

Chairman of Canopus BioPharma, Dr. Patrick Prendergast, stated, "We at Canopus are encouraged with the discovery of this new use for CB1400 to increase efficacy and reduce toxicity issues associated with conventional chemotherapeutic agents."

CB1400, a former schistosomal drug, is currently in phase II clinical development as an anti-mucositis preventative agent in patients receiving radio- and/or chemotherapy treatment. Current anti-mucositis drugs have shown tumor-protective properties. For this reason CB1400 was evaluated by Canopus to determine its effect on tumor growth.

In work carried out by the Harvard School of Dental Medicine, Boston, on behalf of Canopus BioPharma, it was confirmed that CB1400 as a single agent significantly reduces tumor growth. In an initial study, tumor growth was inhibited by 48.8% in mice treated with cisplatin, the most commonly used chemotherapy drug. CB1400 alone showed 62.3% tumor growth inhibition while the combination of both compounds further increased inhibition to 69.6%, thus confirming a synergistic effect between cisplatin and CB1400. In addition, there was no evidence of toxicity based on observations of survival and weight change in the mice and there was no evidence that CB1400 protected the tumor.

Cisplatin is a platinum-containing chemotherapeutic drug, administered by IV injection which has been used for more than 30 years to treat various forms of cancer. Enhanced efficacy with CB1400 may prevent the development of drug resistance that is common with cisplatin.

In a similar study, tumor growth was inhibited by 61% in mice treated with cetuximab
'/>"/>

SOURCE Canopus BioPharma, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. China Biopharma, Inc. Announces New Plan of Operation
2. Flash Technology Prevents Pain From Carpal Tunnel Syndrome
3. InSightec Resumes Clinical Trials for Non-Invasive Treatment of Brain Tumors
4. ChemoCentryx Demonstrates Recently Discovered Chemokine Receptor CXCR7 is Essential in Tumor Growth
5. First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs
6. New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties
7. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
8. Celator(R) Pharmaceuticals Study Shows CPX-571 Maintains Synergistic Ratio of Irinotecan and Cisplatin to Improve Anti-tumor Activity
9. Elekta Announces Elekta Infinity - a New System for Faster and More Precise Treatment of Cancer Tumors
10. On the road to a new cancer therapy -- starving the tumor
11. Virginia Commonwealth University to Study Genomics-Based Diagnostic Test: Pathwork Diagnostics Tissue of Origin Test Designed to Aid in Determination of a Tumors Origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... , March 4, 2015 ... innovative Entwicklungen für Diagnostik und Therapie, Strahlendosismanagement und ... Royal Philips (NYSE: PHG, ... Europäischen Röntgenkongress 2015 (ECR) bekannt, der vom ... stattfindet. An den Ständen Nr. 102 and ...
(Date:3/3/2015)... , March 3, 2015  Halozyme Therapeutics, Inc. (NASDAQ: ... 2015 Global Healthcare Conference in Miami, FL ... PT. David A. Ramsay , Chief Financial Officer, will ... webcast through the "Investors" section of Halozyme,s corporate website at ... for 90 days following the event. To access the live ...
(Date:3/3/2015)... 03, 2015 Experts and industry insiders ... one event: the Alltech REBELation exploring innovation, inspiration and ... Now in its 31st year, Alltech’s annual international conference ... and the opportunity to join the REBELation at an ... 11:59 p.m. EST, at which point the standard early ...
(Date:3/3/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ) has ... 2015 - 2025" report to their offering. ... an extensive study on the marketed and pipeline gene ... in this field for over a decade but there ... markets; one approved in the EU). There are many ...
Breaking Biology Technology:Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7
... of EDS services allow Bristol-Myers Squibb to ... focus on core biopharmaceutical business, PLANO, Texas, ... technology (IT) services contract that,calls for EDS to deliver IT ... scale will allow the company to,improve productivity so Bristol-Myers Squibb ...
... Finance Corporation and GE,Healthcare Financial Services have provided ... to Astex Therapeutics Limited. This represents,one of the ... in,Europe., Astex Therapeutics, based in Cambridge, England, ... the UK, concentrating on the discovery,and development of ...
... DBI,s Portfolio of Technologies for Enabling Faster, Easier,Quantification of Protein ... ... Clinical Trials, WALTHAM, Mass., Dec. 10 ... analysis systems for,pharmaceutical research and development, today announced the company,s,PATH(R) ...
Cached Biology Technology:EDS Awarded $715 Million Contract for Bristol-Myers Squibb Information Services 2EDS Awarded $715 Million Contract for Bristol-Myers Squibb Information Services 3Oxford Finance Corporation and GE Healthcare Financial Services Reaffirm Commitment to Biotech Sector in Europe 2Decision Biomarkers Awarded U.S. Patent for Protein Array Surface Chemistry 2
(Date:2/12/2015)... 2015   MedNet Solutions , a global ... management systems, has recently bolstered its ... iMedNet as the eClinical solution ... healthcare consultants.  Building on the Program,s existing benefits ... numerous co-marketing opportunities), MedNet,s new and improved program ...
(Date:2/11/2015)... , February 11, 2015 ... report "Access Control Market by Product (Cards and Readers, ... Military and Defense, Government, Industrial, Healthcare, Education) and By ... by MarketsandMarkets, the Access Control Market is ... growing at a CAGR of 10.6% between ...
(Date:2/9/2015)... Texas , Feb. 9, 2015  Lintec of ... fabrication methods for carbon nanotube (CNT) macrostructures, including sheets, ... at Dallas (UTD). Leveraging the vast industrial ... Tokyo, Japan , Lintec of America is ... Richardson, TX , focusing on scaling up ...
Breaking Biology News(10 mins):MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4
... best-studied single-celled organisms around, is a master of industrial efficiency. ... just one product: itself. It exists to make copies of ... the lowest possible cost, with the greatest possible efficiency. ... by the energy and resources it uses to maintain its ...
... facial structure of an ancient relative of modern humans ... hard nuts and seeds as part of a survival ... team of researchers that includes Florida State University,s Dennis ... Proceedings of the National Academy of Science, ...
... gearing up to return to Russia to oversee preparations for ... launch on 16 March 2009. This follows implementation of the ... delayed the launch of GOCE by Eurockot Launch Services last ... at the Plesetsk Cosmodrome in northern Russia to arrange logistical ...
Cached Biology News:Bacteria are models of efficiency 2March launch planned for ESA's gravity mission 2
... Set from different human fetal normal ... maybe available upon request. Customers ... the whole set, and pay 70% ... All Dr. P Set products are ...
Wheat Germ Agglutinin (WGA) PS SPA Imaging Bead, 2 g. Category: Leadseeker Beads....
... High Five cells (BTI-TN-5B1-4) derived from ... been shown to be capable of ... recombinant proteins compared to other insect ... following features:- -Rapid doubling time as adherent ...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
Biology Products: