Navigation Links
CB1400, Patented by Canopus BioPharma, Prevents Tumor Growth and Enhances the Anti-Tumor Effects of Cisplatin and Cetuximab (Erbitux).
Date:6/19/2008

LOS ANGELES, California, June 19 /PRNewswire-FirstCall/ -- Canopus BioPharma, Inc. (OTC: CBIA), has confirmed the efficacy of its oncology candidate, CB1400, as a tumor reducing agent and has also demonstrated the synergistic effect of this drug in combination with both cisplatin and cetuximab (Erbitux) in two mice lung cancer models.

Chairman of Canopus BioPharma, Dr. Patrick Prendergast, stated, "We at Canopus are encouraged with the discovery of this new use for CB1400 to increase efficacy and reduce toxicity issues associated with conventional chemotherapeutic agents."

CB1400, a former schistosomal drug, is currently in phase II clinical development as an anti-mucositis preventative agent in patients receiving radio- and/or chemotherapy treatment. Current anti-mucositis drugs have shown tumor-protective properties. For this reason CB1400 was evaluated by Canopus to determine its effect on tumor growth.

In work carried out by the Harvard School of Dental Medicine, Boston, on behalf of Canopus BioPharma, it was confirmed that CB1400 as a single agent significantly reduces tumor growth. In an initial study, tumor growth was inhibited by 48.8% in mice treated with cisplatin, the most commonly used chemotherapy drug. CB1400 alone showed 62.3% tumor growth inhibition while the combination of both compounds further increased inhibition to 69.6%, thus confirming a synergistic effect between cisplatin and CB1400. In addition, there was no evidence of toxicity based on observations of survival and weight change in the mice and there was no evidence that CB1400 protected the tumor.

Cisplatin is a platinum-containing chemotherapeutic drug, administered by IV injection which has been used for more than 30 years to treat various forms of cancer. Enhanced efficacy with CB1400 may prevent the development of drug resistance that is common with cisplatin.

In a similar study, tumor growth was inhibited by 61% in mice treated with cetuximab (Erbitux) alone. An almost 30% increase in efficacy was observed with the addition of CB1400 to cetuximab, increasing tumor inhibition to 89.4%, confirming a synergistic effect of combining the two anti-tumor drugs. Similar to the cisplatin study, there was no significant difference in mean weight or survival between the groups of mice; and no toxicity was observed in this study.

Cetuximab is a chimeric monoclonal antibody, an epidermal growth factor receptor inhibitor used as a chemotherapeutic agent, administered by IV injection for the treatment of various cancers. Enhancing the efficacy of cetuximab may have potential in treating patients no longer responding to traditional chemotherapy.

About Canopus BioPharma, Inc.:

Canopus BioPharma, Inc. (OTCBB: CBIA) is dedicated to providing the safest, most cost effective and efficacious pharmaceutical products and assay methods in the areas of infectious disease, radiation protection, cancer, and addiction. With innovative science, proven research and development leadership, and superior products and compounds, Canopus BioPharma has, since 2001, been committed to becoming a market trend setter in a new era of healthcare. In addition, the Company is a world leader in the development of novel camelid antibody products to provide unique avenues of progress and improvement in assay methods and monitoring capabilities for physicians, patients and researchers, initially for food chain protection applications. Canopus maintains staff in Australia, South Africa, Ireland, Panama and the USA. Additional information on the Company is available at http://www.canopusbiopharma.com.


'/>"/>
SOURCE Canopus BioPharma, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. China Biopharma, Inc. Announces New Plan of Operation
2. Flash Technology Prevents Pain From Carpal Tunnel Syndrome
3. InSightec Resumes Clinical Trials for Non-Invasive Treatment of Brain Tumors
4. ChemoCentryx Demonstrates Recently Discovered Chemokine Receptor CXCR7 is Essential in Tumor Growth
5. First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs
6. New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties
7. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
8. Celator(R) Pharmaceuticals Study Shows CPX-571 Maintains Synergistic Ratio of Irinotecan and Cisplatin to Improve Anti-tumor Activity
9. Elekta Announces Elekta Infinity - a New System for Faster and More Precise Treatment of Cancer Tumors
10. On the road to a new cancer therapy -- starving the tumor
11. Virginia Commonwealth University to Study Genomics-Based Diagnostic Test: Pathwork Diagnostics Tissue of Origin Test Designed to Aid in Determination of a Tumors Origin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... 2016  Allergan plc (NYSE: AGN ) a ... Saunders , Allergan,s CEO and President, will be featured ... at the RBC Capital Markets Healthcare Conference on Tuesday, ... New York Palace Hotel in New York, ... and can be accessed on Allergan,s Investor Relations web ...
(Date:2/10/2016)... MO (PRWEB) , ... February 10, 2016 , ... ... will attend the International Society of Pharmaceutical Engineering (ISPE) Rocky Mountain Chapter 21st ... ISPE is expecting to fill more than 100 tables for its annual event, ...
(Date:2/10/2016)... Mateo, CA (PRWEB) , ... February 10, 2016 ... ... of Multiplex Testing (PROMPT), a research registry built on the secure online PatientCrossroads ... September 2014. More than 1,600 participants have joined the PROMPT study, which seeks ...
(Date:2/10/2016)... La Jolla CA (PRWEB) , ... February 10, 2016 , ... ... of new agents for the treatment of Alzheimer’s disease, announced today it has been ... to February 18th at the Breakers in Palm Beach, Florida. The purpose of ...
Breaking Biology Technology:
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... is apparently one of the most popular hubs ... Project, MetaHIT and other huge studies of human ... that past few years, the microbiome space has ... applied biomedical research. This report focuses on ...
(Date:2/3/2016)... Vigilant Solutions announces today that the ... Missouri solved two recent hit-and-run cases with ... Vigilant Solutions. Brian Wenberg explains, "I ... was walking out of a convenience store and witnessed an elderly male back ... striking his vehicle and leaving the scene.  In his ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
Breaking Biology News(10 mins):