Navigation Links
Building better catalysts
Date:9/29/2011

he Utah researchers developed a new method for rapidly identifying and designing what are known as "asymmetric catalysts," which are catalyst molecules that are considered either left-handed or right-handed because they are physically asymmetrical. In chemistry, this property of handedness is known as chirality.

Chemists want new asymmetric catalysts because they impart handedness or chirality to the molecules they are used to make. For example, when a left-handed or right-handed catalyst is used to speed a chemical reaction, the chemical that results from that reaction can be either left-handed or right-handed.

"Handedness is an essential component of a drug's effectiveness," Sigman says.

Drugs generally work by latching onto proteins involved in a disease-causing process. The drug is like a key that fits into a protein lock, and chirality "is the direction the key goes" to fit properly and open the lock, says Sigman.

"However, developing asymmetric catalysts [to produce asymmetric drug molecules] can be a time-consuming and sometimes unsuccessful undertaking" because it usually is done by trial and error, he adds.

Sigman says the new study "is a step toward developing faster methods to identify optimal catalysts and insight into how to design them."

A Mathematical Approach to Catalyst Design

Harper and Sigman combined principles of data analysis with principles of catalyst design to create a "library" of nine related catalysts that they hypothesized would effectively catalyze a given reaction one that could be useful for making new pharmaceuticals. Essentially, they used math to find the optimal size and electronic properties of the candidate catalysts.

Then the chemists tested the nine catalysts known as "quinoline proline ligands" to determine how well their degree of handedness would be passed on to the chemical reaction products the catalysts were used to produce.

Sigma
'/>"/>

Contact: Lee Siegel
lee.siegel@utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. PointCross Releases Catalyst for Building Business-Ready SharePoint Solutions in 1/10th the Time
2. Photo-catalytic, self cleaning coating for building exteriors
3. Techstreet Launches BuildingBlocks Utility for Industry Standards Saving Time and Increasing Productivity for Engineers
4. Arts Way Manufacturing Announces Launch of New Web Site For Arts Way Scientific - Buildings For Science
5. Secret of sandcastle construction could help revive ancient building technique, researchers say
6. Building better bone replacements with bacteria
7. Hendrick Construction Renovates USC Science Building
8. RPJ Housings Rebuilding Together Event Brings Estimated $300,000 Worth Of Volunteer Labor to Northern VA
9. Building Biotech Technology Transfer Opportunities: Sponsor and Developer Strategies for Success
10. Penn collaboration leads to simpler method for building varieties of nanocrystal superlattices
11. Building a smaller, lighter future: Understanding polymer behaviors below 1 nanometer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Building better catalysts
(Date:8/29/2014)... -- Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology ... difficult to manufacture proteins including biosimilar therapeutics, today ... for the second quarter ended June 30, 2014. ... initial public offering, we have the capital to ... from our proprietary protein expression platform," stated Bertrand ...
(Date:8/29/2014)... Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" ... reported financial results for the six months ended ... expressed in Canadian dollars and presented under International ... 2014 Highlights , Announced top-line results ... primary endpoint for subjects enrolled in the Phase ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Intrinsic ... 13485:2003 certified, GAMP® 5 compliant imaging core lab, ... international Phase II clinical trial to assess a ... Throughout this trial, Intrinsic Imaging will provide comprehensive ... to, protocol and charter development, site qualification, site ...
(Date:8/28/2014)... Ind. A new research platform uses ... of tiny structures undergoing stress and heating, ... improve designs for microelectronics and batteries., This ... information about how heating and the surface ... properties. Researchers have discussed the merits of ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... N.Y. Researchers at Rensselaer Polytechnic Institute have ... of gold that measure only billionths of a ... equipment and works on nearly any surface including ... and semiconductor manufacturing. Sang-Kee Eah, assistant professor ...
... June 16 Trans World Alloys (TWA), one of the country,s ... Brennan has joined the company, as its new Chief Operating Officer. ACCORDING ... years experience in the metal business in a variety of areas." , ... Ed has attended the University of ...
... , , ... Thorne Ltd. (TSX-V: HTL), a leading provider of advanced laser systems and ... the launch of the Staccato(TM) multi-pulse laser system at the 8th Annual ... 16-19, 2010 , in San Francisco, CA. Staccato(TM) will add ...
Cached Biology Technology:Researchers develop ultra-simple method for creating nanoscale gold coatings 2Ed Brennan - New C.O.O. of Trans World Alloys 2Hamilton Thorne to launch Staccato(TM) laser at International Society of Stem Cell Research Annual Meeting 2Hamilton Thorne to launch Staccato(TM) laser at International Society of Stem Cell Research Annual Meeting 3Hamilton Thorne to launch Staccato(TM) laser at International Society of Stem Cell Research Annual Meeting 4
(Date:8/28/2014)... healthier for your neighbors than traditional cigarettes, but ... a new study from USC. , Scientists studying ... decrease in exposure to harmful particles, with close-to-zero ... to some harmful metals in second-hand e-cigarette smoke ... tobacco smoke contains high levels of polycyclic aromatic ...
(Date:8/28/2014)... MINNEAPOLIS/ST. PAUL (August 28, 2014) Researchers at the ... for facioscapulohumeral muscular dystrophy (FSHD) to be used for ... effectiveness of potential therapies for FSHD. , The research ... Cell Reports . , There is no treatment ... the most common type of muscular dystrophy. FSHD is ...
(Date:8/28/2014)... N.C. -- Scientists have identified the developmental on-off switch ... that produce more than two-thirds of the world,s naturally ... be to see whether it is possible to manipulate ... , The study, appearing August 28 in ... small molecule called cyclic-di-GMP and a larger protein called ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2UMN researchers find animal model for understudied type of muscular dystrophy 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3
... MINNETONKA, Minn., Feb. 8, 2011 MedNet Solutions, ... in clinical study management systems, is pleased to ... the company,s flagship eClinical solution.  The ENLIGHTEN ... and easy-to-use electronic data capture (EDC) and clinical ...
... of the turtle world swimming farther, diving deeper and ... But for all their toughness, they have still suffered a ... Ocean over the last 20-plus years, largely at the hands ... tagging and tracking the turtles are providing insights into their ...
... their ability to exhibit the "Cheerios effect" when they move ... together like Cheerios swimming in milk in a cereal bowl ... has made Virginia Tech engineers speculate about the possible impacts ... the journal, Soft Matter , a publication of the ...
Cached Biology News:MedNet Solutions Announces Significant Enhancements to ENLIGHTEN, Its Flagship EDC / eClinical Solution 2Why leatherback turtles linger in South Pacific Gyre, and why it matters 2Why leatherback turtles linger in South Pacific Gyre, and why it matters 3Why leatherback turtles linger in South Pacific Gyre, and why it matters 4When worms stick together and swim on thin water, what happens and why does it matter? 2
... choice of PDMS Stamps (3 PDMS micropatterned ... micron squares or 100 um x 10 ... lines, 3 PDMS nano-patterned stamps with depth ... pitch of 400 nm, or 3 PDMS ...
Request Info...
RECOMBINANT EQUINE IL-4 Product Type: Recombinant Protein...
Request Info...
Biology Products: