Navigation Links
Bucindolol Significantly Reduces Hospitalization and Death in Heart Failure Patients With Very Favorable Genotypes
Date:9/22/2008

experienced significant improvements in clinical endpoints compared to placebo, including reductions in all cause mortality, all cause mortality or transplant, cardiovascular mortality, heart failure hospitalization, and cardiovascular hospitalization. While the most robust clinical effects occurred in the very favorable genotype group, patients with the favorable genotype also benefitted from treatment with bucindolol. Bucindolol also demonstrated clinically significant improvements in ischemic endpoints including reducing the risk of myocardial infarction.

"Bucindolol offers physicians a tremendous advantage to predict response," said William Abraham, M.D., Director of Cardiovascular Medicine at the Ohio State University Medical Center. "This is vitally important since the annual mortality rate for heart failure patients can be as high as 20 percent. With these patients, we have no time to spare."

Michael Bristow, M.D., Chairman and Chief Science and Medical Officer of ARCA biopharma, said, "While currently available beta blockers are a mainstay in medicine, it is difficult for physicians to predict which patients will respond to which therapy. Bucindolol interacts with certain polymorphisms of adrenergic receptors that help regulate cardiac function, allowing us to predict patient clinical response using a simple genetic test. The time is coming when we can realize the benefits of personalized medicine in cardiovascular disease."

About Beta Blockers

The use of beta blockers is the standard of care in patients with heart failure and left ventricular dysfunction, according to clinical practice guidelines of the Heart Failure Society of America (HFSA), the American Heart Association and the American College of Cardiology. HFSA guidelines state: "Beta-blocker therapy remains a major advance in the treatment of patients with LV systolic dysfunction. Along with ACE inhibitors, this class of drug is now established as routine therapy in pati
'/>"/>

SOURCE ARCA biopharma, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
2. Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy
3. Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo
4. UCB Announces New Data Showing Investigational Drug Lacosamide Significantly Reduced Seizures in Refractory Epilepsy Patients
5. New Phase 3 Data Showed PRISTIQ Significantly Reduced Symptoms of Major Depressive Disorder Versus Placebo
6. Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer
7. Cord Blood America CEO Matthew Schissler Says Operations Significantly Streamlined
8. Treatment with Paliperidone ER May Be Associated with Significantly Reduced Use of Mental Health Resources
9. Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis
10. On the boil: New nano technique significantly boosts boiling efficiency
11. Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... , Sept. 30, 2014 CORD:USE Cord Blood ... announce that it has entered into an Equity and ... which has licensed a series of patented technologies for the ... possible clinical applications.  Tianhe is performing Phase I/II clinical ... Spain using Tianhe,s Stem Cell Educator ...
(Date:9/30/2014)... Basel, Switzerland (PRWEB) September 30, 2014 ... advanced software solutions for drug discovery and ... the FUNGITECT consortium has chosen Genedata Selector ... next-generation sequencing (NGS) data. FUNGITECT is a ... of invasive fungal diseases via individualized anti-fungal ...
(Date:9/30/2014)... CORALVILLE, Iowa , Sept. 30, 2014 /PRNewswire/ ... in the discovery and development of proprietary new ... United States Patent and Trademark Office (USPTO) issued ... patent application entitled, "Benzoic Acid, Benzoic Acid Derivatives ... Methods of Making and Use Thereof." ...
(Date:9/30/2014)... DEL MAR, Calif. , Sept. 30, 2014 /PRNewswire/ ... devices for women,s health announces its receipt of a ... The FemmyCycle menstrual cup has also received FDA clearance ... Health Canada, and the CE in Europe. This patent is ... design. In conjunction with this issuance, the company is releasing ...
Breaking Biology Technology:CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2The FemmyCycle 2
... The Board of Directors of Schering-Plough Corporation (NYSE: SGP ... share. Payment will be made on Aug. 31, 2009, to ... 2009. As of March 31, 2009, there were 1,628,335,093 common ... also declared a quarterly dividend of $3.75 per share on the ...
... BASEL, Switzerland, June 23 Syngenta announced today the successful ... year maturity. The proceeds of the bond will be used ... said: "We have taken advantage of favorable current borrowing conditions ... bond issue is part of our normal funding requirements and ...
... SyntheMed, Inc. (OTC Bulletin Board: SYMD), a biomaterials ... products, announced today that the company was recently nominated ... in pediatrics. The company is among three ... device analysts in recognition of the development of REPEL-CV(TM) ...
Cached Biology Technology:Syngenta Issues EUR 500 Million Eurobond 2SyntheMed Receives Frost & Sullivan Health Innovation Award Nomination 2
(Date:9/30/2014)... hope: A new research report published in October 2014 ... explains how scientists developed a synthetic version of a ... in human and mouse eggs similar to the natural ... fertilization. , "We believe that the results of this ... of human fertilization by providing a precise answer to ...
(Date:9/30/2014)... suite of perilous threats in today,s ocean. From ... change, fragile coral ecosystems are disappearing at unprecedented ... species of corals surrounding the island of Moorea ... their tropical environment: coral guard-crabs. New research from ... Station scientist Seabird McKeon and the museum,s predoctoral ...
(Date:9/29/2014)... of gut bacteria called Clostridium ramosum , coupled with ... work is published this week in mBio , the ... , A research team from the German Institute of Human ... bacteria including C. ramosum gained weight when fed ... ramosum were less obese even when consuming a high-fat ...
Breaking Biology News(10 mins):Synthetic sperm protein raises the chance for successful in vitro fertilization 2Smithsonian scientists discover coral's best defender against an army of sea stars 2Gut bacteria promote obesity in mice 2
... microscope integrates two Finnish innovations and brings new dimensions ... for Molecular Medicine Finland (FIMM) have in collaboration with ... finger gesture controlled microscope. The method is a combination ... multitouch display. The result is an entirely new ...
... Congress on Osteoporosis & Osteoarthritis in Valencia, Spain, Professor ... Pierre D. Delmas Prize. The prestigious award, ... Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International ... an individual who has made outstanding and major scientific ...
... - A lot of chatter goes on inside each one ... ears. Researchers at McMaster University discovered that the "cross-talk" ... important role in the development of psychiatric illness, intestinal diseases ... "The wave of the future is full of opportunity as ...
Cached Biology News:Big size multitouch display turned into a microscope 2ESCEO-IOF Servier Pierre D. Delmas Prize awarded to John. A. Kanis 2'Knowing it in your gut' is real 2
...
TNM-FH Insect Medium 1 liter...
D.R. Harper (1993) • Includes: essential information on taxonomy, culture and safe handling of viruses, immunology, monoclonal antibodies, antivirals and vaccines....
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
Biology Products: