Navigation Links
Broad-scale genome tinkering with help of an RNA guide
Date:7/28/2013

ed that their tool could turn on very specific genes in human cells. They went on to demonstrate use of the tool to modify targets of interest for fighting inflammation and activating gene networks for making neurons, muscle cells or stem cells. They showed they could induce a gene known to alleviate symptoms of sickle cell disease, too.

In other words, it works, and it works on genes that matter from a clinical perspective. In principle, the RNA-guided tool could be used to modify or influence any gene anywhere in the genome.

Gersbach now hopes to apply the new tool along with collaborators in the IGSP to investigate the functions of thousands of sites across the genome. With tissue engineer Farshid Guilak, a professor of engineering and orthopaedic surgery, he will continue to work on its application in the fight against inflammatory and autoimmune diseases such as arthritis.

"This simple and versatile tool makes it easy for anyone to do this," Gersbach says.


'/>"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-2850
Duke University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Worlds First IVF Baby Born after Preimplantation Genome Sequencing is Now 11 Months Old
2. Rapid Identification and Strain Typing of Salmonella in Food Using Genome Sequence Scanning Technology
3. Personal Genome Diagnostics And Blueprint Medicines Form Collaboration to Identify Novel Kinase Targets
4. Venter Institute-Led Team Recovers and Sequences Genome of Periodontal Pathogen from Biofilm in Hospital Sink using Single-Cell Genomics
5. Personal Genome Diagnostics Inc. Licenses Genome-Mapping Technology from Johns Hopkins University and Expands Its Cancer Genome Analysis Business
6. New York Genome Institute Selects Exemplar LIMS to Manage Next Gen Sequencing Labs
7. The Genome Analysis Center Selects Convey to Support Next-Generation Sequencing
8. Whole Genome Sequencing of Triple Negative Breast Cancer Reveals Previously Unreported Mutations
9. Pig genome offers insights into the feistiest of farm animals
10. Researchers unlock disease information hidden in genomes control circuitry
11. In massive genome analysis ENCODE data suggests gene redefinition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... San Francisco, California (PRWEB) July 28, 2014 ... reach USD 604.40 billion by 2020, according to a ... scope coupled with the rising demand for effective vaccines ... to patients with unmet medical needs is expected to ... addition, the need to enhance agricultural productivity via the ...
(Date:7/28/2014)... IN (PRWEB) July 28, 2014 The ... Center, in Muncie IN, is pleased to announce that ... the National Museum of the United States Air Force. ... a year-long process that concluded this spring with an ... the Dayton, OH museum. , The National Museum ...
(Date:7/25/2014)... Trillions of bacteria live in each person,s digestive tract. ... food and stave off harmful infections, but their role ... help shed light on the role of these bacteria, ... Eric Alm recently tracked fluctuations in the bacterial populations ... findings, described in the July 25 issue of the ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 WABC Radio show ... Pet with Lorry Young will be hosting California-based Vet-Stem, ... about stem cell therapy in pets. Dr. Harman first ... of stem cell therapy for pets suffering from osteoarthritis and ... Regenerative Veterinary Medicine industry forward. , Young has invited Dr. ...
Breaking Biology Technology:Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3
... BEIJING, Nov. 4, 2011 /PRNewswire-Asia-FirstCall/ -- China Biologic Products, Inc. ... leading plasma-based biopharmaceutical companies in China, today announced that it ... 2011 financial results on Tuesday, November 8, 2011 at 8:00 ... China on the same day. Hosting the call ...
... Major milestone achieved in the commercial launch of ... ascites due to liver cirrhosis. Sequana Medical, ... (AKH Wien) reported that the first two commercial implants ... General Hospital in October, under the supervision of Univ. ...
... Nov. 3, 2011 Cumberland Pharmaceuticals Inc. (NASDAQ: ... hospital acute care and gastroenterology markets, today announced third quarter ... the three months ended September 30, 2011, net revenue was ... period. The growth in net revenue was driven by an ...
Cached Biology Technology:China Biologic to Host Earnings Conference Call on November 8, 2011 at 8:00 a.m. EST (NY) 2The Medical University of Vienna and Vienna General Hospital Perform the First two Commercial Implants Worldwide of Sequana Medical's ALFApump® System 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 3Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 4Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 5Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 6Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 7Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 8Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 9Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 10Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 11Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 12
(Date:7/28/2014)... Roald Amundsen became the first man to reach the ... years later, an international team of scientists led by ... proven that air pollution from industrial activities arrived long ... from widely spaced locations around the Antarctic continent, including ... and precise reconstruction to date of lead pollution over ...
(Date:7/27/2014)... of mayfly in the southern Western Ghats, a mountain range ... the first time that any mayfly belonging to the genus ... The new species, called Labiobaetis soldani , "is named ... to the understanding of the Ephemeroptera of Palaearctic and Oriental ... the new mayfly in the Journal of Insect Science ...
(Date:7/27/2014)... In an age of "big data," a single computer ... tasks must instead be distributed across a cluster of ... how Facebook and Google mine your web history to ... Netflix recommend your next favorite book or movie. But ... , New technologies for monitoring brain activity are generating ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... on Display at Leading Healthcare Conference, ... Identity,management in a busy healthcare setting ... when it must be repeated with each ... a leading supplier of,innovative computer products, and ...
... the University of Pennsylvania School of Veterinary Medicine have ... modification of large animals. The method employs a ... to male reproductive cells, which is then passed naturally ... director of the Center for Animal Transgenesis and Germ ...
... Athens, Ga. When West Nile virus first struck ... fatal illness alarmed citizens and public health officials alike, ... vector-borne diseases. Although West Nile virus has been widely ... ecology of mosquito-borne diseases differs between urban and rural ...
Cached Biology News:Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 2Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 3Fujitsu and HT Systems Partner to Provide Biometric Patient Identity Management 4Penn Veterinary Medicine report new strategy to create genetically-modified animals 2UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC 2
Size & Applications: 100 ul (2 mM). Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.) Storage Temp.: -20C Shelf Life: 6-12 month...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Request Info...
...
Biology Products: