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Broad-scale genome tinkering with help of an RNA guide
Date:7/28/2013

ed that their tool could turn on very specific genes in human cells. They went on to demonstrate use of the tool to modify targets of interest for fighting inflammation and activating gene networks for making neurons, muscle cells or stem cells. They showed they could induce a gene known to alleviate symptoms of sickle cell disease, too.

In other words, it works, and it works on genes that matter from a clinical perspective. In principle, the RNA-guided tool could be used to modify or influence any gene anywhere in the genome.

Gersbach now hopes to apply the new tool along with collaborators in the IGSP to investigate the functions of thousands of sites across the genome. With tissue engineer Farshid Guilak, a professor of engineering and orthopaedic surgery, he will continue to work on its application in the fight against inflammatory and autoimmune diseases such as arthritis.

"This simple and versatile tool makes it easy for anyone to do this," Gersbach says.


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Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-2850
Duke University
Source:Eurekalert

Page: 1 2

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