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Bristol-Myers Squibb Company Outlines Strategy and Productivity Transformation Initiative During Update to Investment Community
Date:12/5/2007

ed in supplemental materials available on the company's website.

"With this adjustment to earnings guidance and the dividend increase, we're sending a clear message of confidence: We expect to be able to continue to reward our shareholders for their support, well into the future," said Mr. Cornelius.

Research and Development Update

In addition to discussing progress in transforming the R&D organization into a next-generation BioPharma model and executing its biologic strategy, the company also will provide an update on key late and early stage compounds in its pipeline. The company will continue to focus its efforts on serious disease - in both specialty areas and high prevalence illnesses - where there is significant unmet medical need. Senior members of the R&D organization will outline the strategy of building pipelines within products by broadening their clinical use through multiple indications.

Specific updates will focus on the company's late-stage programs in oncology, diabetes, cardiovascular disease and solid organ transplant rejection, including:

-- developmental diabetes compounds saxagliptin, a DPP4-inhibitor, and

dapagliflozin, a novel SGLT-2 inhibitor, both of which are being

developed in partnership with AstraZeneca PLC; the company reiterated

its plan to submit saxagliptin for filing with the U.S. Food and Drug

Administration (FDA) in 2008;

-- two cancer drugs: the internally developed and recently approved

Ixempra (ixabepilone), a new cytotoxic designed to overcome drug

resistance; and ipilimumab (MDX-010), a potential new immunotherapy

paradigm;

-- an internally discovered biologic investigational compound,

belatacept, a novel co-stimulation blocker under development to

replace cornerstone therapy in solid organ transplantation, which the

company expects to submit to the FDA for filing in the
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SOURCE Bristol-Myers Squibb Company
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