Navigation Links
Bristly spheres as capsules

This release is available in German.

Amphiphilic molecules, which have one water-friendly (hydrophilic) end and one water-repellant (hydrophobic) end, spontaneously aggregate in aqueous solutions to make superstructures like capsules or bilayers. This phenomenon is responsible for the effects of detergents and soaps. Dirt is enclosed in little capsules of surfactant, which makes it water-soluble. Cell membranes are also based on this principle: they are simply lipid bilayers, an aggregation of lipid molecules that line up with their hydrophobic tails all together and their hydrophilic heads protruding into the aqueous environment. As reported in the journal Angewandte Chemie, researchers at the Universities of Hamburg and Freiburg (Germany) led by Horst Weller and Stephan Frster have now produced amphiphilic hybrid particles made of a water-insoluble inorganic nanoparticle at the core surrounded by a bristle-like layer of hydrophilic polymer chains.

The inorganic nanoparticles are made of cadmium selenide and cadmium sulfide. Polyethylene oxide chains are attached to the nanoparticles through amino groups. The nature of the superstructures formed in aqueous solution depends on how densely the surfaces of the little spheres are covered with the polymer "bristles". If they are densely packed, the hybrid particles remain in solution as individuals, because the bristles repel each other. If the bristles are less dense, dimers and trimers are formed; still sparser bristles result in long wormlike aggregates of many particles that grow into a network through occasional Y-shaped branches. For the particles to aggregate in this way, the bristles on the surfaces of the inorganic cores have to reorganize significantly: they move aside a little to free up points of contact so the cores can attach to each other. Aggregation then continues until the resulting ensemble of cores is, as a whole, surrounded by a sufficiently dense layer of bristles, which acts as a shield toward additional particles.

Cores with an even smaller number of polymer bristles aggregate into extended curved layers that close themselves off into capsule-shaped vesicles. The walls of the vesicles consist of a monolayer of the bristly particles.

The polymer-coated spheres offer a new, simple method for the controlled production of superstructures. The vesicles could be used to encapsulate drugs, for example, as contrast agents, or as ordered liquid crystalline phases for the production of nanostructured hybrid materials.


Contact: Stephan Foerster

Related biology technology :

1. First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform
2. SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres
3. CeloNova BioSciences Announces Worlds First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres
4. FDA Approves KAPIDEX(TM) (Dexlansoprazole) delayed release capsules for the Treatment of GERD
5. China Pharma Holdings, Inc. Receives SFDA Production Approval for Tiopronin Enteric-Coated Capsules
6. Cephalon and Eurand Announce Notification of Generic Filing for Cyclobenzaprine Hydrochloride Extended-Release Capsules
7. NicOx Signs Agreement With Capsugel for the Commercial Manufacture of Naproxcinod Oral Capsules
8. Barr Receives Approval for Generic Version of Razadyne(R) ER Capsules
9. FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting
10. Ranbaxy Launches Omeprazole 40 mg Capsules
11. Par Pharmaceutical Receives Final Approval to Market Generic Marinol(R) CIII (Dronabinol) Capsules
Post Your Comments:
Related Image:
Bristly spheres as capsules
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... their findings on what they believe could be a new and helpful biomarker ... new research. Click here to read it now. , Biomarkers are ...
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
Breaking Biology Technology:
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):