Navigation Links
Bristly spheres as capsules
Date:3/6/2009

This release is available in German.

Amphiphilic molecules, which have one water-friendly (hydrophilic) end and one water-repellant (hydrophobic) end, spontaneously aggregate in aqueous solutions to make superstructures like capsules or bilayers. This phenomenon is responsible for the effects of detergents and soaps. Dirt is enclosed in little capsules of surfactant, which makes it water-soluble. Cell membranes are also based on this principle: they are simply lipid bilayers, an aggregation of lipid molecules that line up with their hydrophobic tails all together and their hydrophilic heads protruding into the aqueous environment. As reported in the journal Angewandte Chemie, researchers at the Universities of Hamburg and Freiburg (Germany) led by Horst Weller and Stephan Frster have now produced amphiphilic hybrid particles made of a water-insoluble inorganic nanoparticle at the core surrounded by a bristle-like layer of hydrophilic polymer chains.

The inorganic nanoparticles are made of cadmium selenide and cadmium sulfide. Polyethylene oxide chains are attached to the nanoparticles through amino groups. The nature of the superstructures formed in aqueous solution depends on how densely the surfaces of the little spheres are covered with the polymer "bristles". If they are densely packed, the hybrid particles remain in solution as individuals, because the bristles repel each other. If the bristles are less dense, dimers and trimers are formed; still sparser bristles result in long wormlike aggregates of many particles that grow into a network through occasional Y-shaped branches. For the particles to aggregate in this way, the bristles on the surfaces of the inorganic cores have to reorganize significantly: they move aside a little to free up points of contact so the cores can attach to each other. Aggregation then continues until the resulting ensemble of cores is, as a whole, surrounded by a sufficiently dense layer of bristles, which acts as a shield toward additional particles.

Cores with an even smaller number of polymer bristles aggregate into extended curved layers that close themselves off into capsule-shaped vesicles. The walls of the vesicles consist of a monolayer of the bristly particles.

The polymer-coated spheres offer a new, simple method for the controlled production of superstructures. The vesicles could be used to encapsulate drugs, for example, as contrast agents, or as ordered liquid crystalline phases for the production of nanostructured hybrid materials.


'/>"/>

Contact: Stephan Foerster
forster@chemie.uni-hamburg.de
49-404-283-83460
Wiley-Blackwell
Source:Eurekalert  

Related biology technology :

1. First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform
2. SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres
3. CeloNova BioSciences Announces Worlds First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres
4. FDA Approves KAPIDEX(TM) (Dexlansoprazole) delayed release capsules for the Treatment of GERD
5. China Pharma Holdings, Inc. Receives SFDA Production Approval for Tiopronin Enteric-Coated Capsules
6. Cephalon and Eurand Announce Notification of Generic Filing for Cyclobenzaprine Hydrochloride Extended-Release Capsules
7. NicOx Signs Agreement With Capsugel for the Commercial Manufacture of Naproxcinod Oral Capsules
8. Barr Receives Approval for Generic Version of Razadyne(R) ER Capsules
9. FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting
10. Ranbaxy Launches Omeprazole 40 mg Capsules
11. Par Pharmaceutical Receives Final Approval to Market Generic Marinol(R) CIII (Dronabinol) Capsules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bristly spheres as capsules
(Date:2/10/2016)... La Jolla CA (PRWEB) , ... February 10, 2016 , ... ... of new agents for the treatment of Alzheimer’s disease, announced today it has been ... to February 18th at the Breakers in Palm Beach, Florida. The purpose of ...
(Date:2/9/2016)... FALLS, N.J. , Feb. 9, 2016 /PRNewswire/ ... a biotechnology company specializing in the development and ... health of damaged tissues and organs, recently reported ... for the first quarter of 2016. ... began the new 2015 fiscal year in the ...
(Date:2/9/2016)... Sunnyvale, CA (PRWEB) , ... February 09, 2016 ... ... will present its latest innovations on its free and validated Electronic Data Capture ... Booth #81 the Outsourcing in Clinical Trials West Coast 2016 Conference in San ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... changes over the years and Open Access publishing is one of the popular ... its 700+ open access journals and 3000+ International Conferences ...
Breaking Biology Technology:
(Date:2/2/2016)... , Feb. 2, 2016  Based on its ... & Sullivan recognizes US-based Intelligent Retinal Imaging Systems ... Sullivan Award for New Product Innovation. IRIS, a ... North America , is poised to ... growing diabetic retinopathy market. The IRIS technology presents ...
(Date:1/28/2016)... SYNA ), a leading developer of human interface solutions, today ... --> --> Net revenue ... to the comparable quarter last year to $470.5 million. Net income ... $0.93 per diluted share. --> ... 2016 grew 9 percent over the prior year period to $60.3 ...
(Date:1/22/2016)... , January 22, 2016 ... the addition of the  "Global Behavioral ... offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ... "Global Behavioral Biometric Market 2016-2020"  report ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ...
Breaking Biology News(10 mins):