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Bright Future Ahead for Biopharmaceutical Contract Manufacturing, Says Frost & Sullivan
Date:10/1/2013

een sites and their ability of being easily expandable for larger volumes.

Advances in upstream and downstream processing technologies will also impact the industry. With 20 percent of biotech manufacturing costs accounting for upstream processing activities, and 40 percent for downstream ones, most companies and CMOs are gearing up to adopt new technologies to optimise efficiency. In 2011 the global industry witnessed a 6.2 percent budget increase for integrating new technologies in upstream processing. Reduction of quality variability in the product - impurities such as aggregates, glycosylation variants, and so forth - and cell viability will be the key focus areas of upstream processing in biomanufacturing. Downstream processing technologies follow two different trends specific to mAbs and recombinant proteins, specifically in the purification processes. In the next five years, exploration of alternative purification methods will be crucial for CMOs.

Advances in lyophilisation and increasing applications of process analytical technology (PAT) will also attract attention. Innovations such as automated loading processes into the dryer in place of manual loading contribute to minimising human error and maximising productivity. Also, manufacturers increasingly prefer the implementation of PAT and standardisation of their processes, rather than relying on the validation of finished products. Near infrared spectroscopy (NIR) is one of the latest technologies which provides potential real-time control of cells in fermentation, specifically in mammalian cell culture processes. The significant enhancement of purity levels and product efficiency are expected to drive the demand for this novel technology throughout the forecast period.

Mammalian cell-based contract manufacturing is expected to sustain the industry's future expansion. This segment currently constitutes nearly two thirds of the sales revenue of the global biopharmaceutical contract man
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SOURCE Frost & Sullivan
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